Fit and compare nonlinear mixed-effects models in
differential equations with flexible dosing information commonly seen
in pharmacokinetics and pharmacodynamics (Almquist, Leander, and
Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation
solving is by compiled C code provided in the 'rxode2' package (Wang,
Hallow, and James 2015 <doi:10.1002/psp4.12052>).
| Version: |
6.0.1 |
| Depends: |
nlmixr2data, R (≥ 4.1.0) |
| Imports: |
backports, checkmate, cli, graphics, knitr, lbfgsb3c, lotri, Matrix, methods, minqa, n1qn1 (≥ 6.0.1-12), nlme, Rcpp, rex, rxode2 (≥ 5.1.2), stats, symengine, utils |
| LinkingTo: |
BH, n1qn1 (≥ 6.0.1-12), lbfgsb3c (≥ 2024-3.5), lotri (≥
0.5.0), Rcpp, RcppArmadillo (≥ 0.11.2.3.1), RcppEigen, rxode2 (≥ 5.1.1) |
| Suggests: |
broom.mixed, crayon, data.table, devtools, digest, dplyr (≥
1.1.0), generics, nloptr, qs2, sys, testthat, tibble, withr, xgxr, sfsmisc, minpack.lm, remotes, fastGHQuad, rmarkdown, rlang |
| Published: |
2026-06-03 |
| DOI: |
10.32614/CRAN.package.nlmixr2est |
| Author: |
Matthew Fidler 
[aut, cre],
Wenping Wang [aut],
Audrey Lavenu [ctb],
Ben Goodrich [ctb],
David Ardia [cph],
Dirk Eddelbuettel [cph],
Elizabeth Eskow [ctb],
Emmanuelle Comets [ctb],
Hadley Wickham [ctb],
Hajar Besbassi [ctb],
Johannes Pfeifer [ctb],
Justin Wilkins
[aut],
Katharine Mullen [cph],
Mahmoud Abdelwahab [ctb],
Marc Lavielle [ctb],
Mason McComb
[ctb],
Mirjam Trame [ctb],
Richard Hooijmaijers [aut],
Rik Schoemaker
[aut],
Robert B. Schnabel [ctb],
Robert Leary [ctb],
Teun Post [ctb],
Vipul Mann [aut],
Yuan Xiong [aut] |
| Maintainer: |
Matthew Fidler <matthew.fidler at gmail.com> |
| License: |
GPL (≥ 3) |
| URL: |
https://github.com/nlmixr2/nlmixr2est,
https://nlmixr2.github.io/nlmixr2est/ |
| NeedsCompilation: |
yes |
| Language: |
en-US |
| Citation: |
nlmixr2est citation info |
| Materials: |
NEWS |
| CRAN checks: |
nlmixr2est results |