Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector and covariance matrix per study) rather than individual-level data. Integrates with the 'nlmixr2'/'rxode2' ecosystem via three estimation methods: a First-Order ('FO') analytical estimator, a Monte Carlo (MC) estimator, and an Iterative Reweighting Monte Carlo ('IRMC') estimator. Methods are based on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software described in van de Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>.
| Version: | 0.1.0 |
| Depends: | R (≥ 4.1.0) |
| Imports: | checkmate, digest, nlmixr2est, nloptr, qs2, randtoolbox, Rcpp, rxode2 |
| LinkingTo: | Rcpp, RcppEigen |
| Suggests: | expm, furrr, future, ggplot2, knitr, mnormt, nlmixr2, patchwork, rmarkdown, testthat (≥ 3.0.0) |
| Published: | 2026-06-02 |
| DOI: | 10.32614/CRAN.package.admixr2 |
| Author: | H. van de Beek [aut, cre], P.A.J. Välitalo [aut], L.B. Zwep [aut], J.G.C. van Hasselt [aut] |
| Maintainer: | H. van de Beek <h.van.de.beek at lacdr.leidenuniv.nl> |
| BugReports: | https://github.com/LeidenPharmacology/admixr2/issues |
| License: | GPL (≥ 3) |
| URL: | https://leidenpharmacology.github.io/admixr2/, https://github.com/LeidenPharmacology/admixr2 |
| NeedsCompilation: | yes |
| Citation: | admixr2 citation info |
| Materials: | README, NEWS |
| CRAN checks: | admixr2 results |
| Reference manual: | admixr2.html , admixr2.pdf |
| Vignettes: |
Getting started with admixr2 (source, R code) |
| Package source: | admixr2_0.1.0.tar.gz |
| Windows binaries: | r-devel: admixr2_0.1.0.zip, r-release: admixr2_0.1.0.zip, r-oldrel: admixr2_0.1.0.zip |
| macOS binaries: | r-release (arm64): admixr2_0.1.0.tgz, r-oldrel (arm64): admixr2_0.1.0.tgz, r-release (x86_64): admixr2_0.1.0.tgz, r-oldrel (x86_64): admixr2_0.1.0.tgz |
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