Fit and compare nonlinear mixed-effects models in
differential equations with flexible dosing information commonly seen
in pharmacokinetics and pharmacodynamics (Almquist, Leander, and
Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation
solving is by compiled C code provided in the 'rxode2' package (Wang,
Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for
support functions like preconditioned fits
<doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate
selection.
| Version: |
5.0.0 |
| Depends: |
R (≥ 4.0) |
| Imports: |
checkmate, cli (≥ 3.4.0), crayon, data.table, digest, dplyr, ggplot2, ggtext, knitr, lotri, methods, nlme, nlmixr2est (≥
5.0.0), Rcpp, rxode2 (≥ 5.0.0), stats, symengine, utils |
| LinkingTo: |
Rcpp, RcppArmadillo |
| Suggests: |
brms, nlmixr2data, testthat (≥ 3.0.0), withr, devtools |
| Published: |
2025-11-29 |
| DOI: |
10.32614/CRAN.package.nlmixr2extra |
| Author: |
Matthew Fidler 
[aut, cre],
Vipul Mann [aut],
Vishal Sarsani
[aut],
Christian Bartels [ctb],
Bill Denney [aut] |
| Maintainer: |
Matthew Fidler <matthew.fidler at gmail.com> |
| BugReports: |
https://github.com/nlmixr2/nlmixr2extra/issues/ |
| License: |
GPL (≥ 3) |
| URL: |
https://nlmixr2.github.io/nlmixr2extra/,
https://github.com/nlmixr2/nlmixr2extra/ |
| NeedsCompilation: |
yes |
| Citation: |
nlmixr2extra citation info |
| Materials: |
README, NEWS |
| CRAN checks: |
nlmixr2extra results |