The tcplfit2 R package performs basic concentration-response curve fitting. The original tcplFit() function in the tcpl R package performed basic concentration-response curvefitting to 3 models. With tcplfit2, the core tcpl concentration-response functionality has been expanded to process diverse high-throughput screen (HTS) data generated at the US Environmental Protection Agency, including targeted ToxCast, high-throughput transcriptomics (HTTr) and high-throughput phenotypic profiling (HTPP). tcplfit2 can be used independently to support analysis for diverse chemical screening efforts.
| Version: |
0.1.9 |
| Depends: |
R (≥ 3.5.0) |
| Imports: |
stats, methods, numDeriv, RColorBrewer, stringr, reshape2, ggplot2 (≥ 3.5.0) |
| Suggests: |
knitr, rmarkdown, stringi, DT, data.table, tcpl, prettydoc, testthat (≥ 3.0.0), here, htmlTable, tidyr, dplyr, gridExtra, rmdformats |
| Published: |
2025-07-23 |
| DOI: |
10.32614/CRAN.package.tcplfit2 |
| Author: |
Thomas Sheffield [aut],
Jason Brown  [ctb],
Sarah E. Davidson-Fritz
[ctb],
Madison Feshuk
[ctb, cre],
Lindsay Knupp [ctb],
Zhihui Zhao [ctb],
Richard S Judson
[ctb],
Katie Paul Friedman
[ctb] |
| Maintainer: |
Madison Feshuk <feshuk.madison at epa.gov> |
| BugReports: |
https://github.com/USEPA/CompTox-ToxCast-tcplFit2/issues |
| License: |
MIT + file LICENSE |
| URL: |
https://github.com/USEPA/CompTox-ToxCast-tcplFit2 |
| NeedsCompilation: |
no |
| Materials: |
README, NEWS |
| CRAN checks: |
tcplfit2 results |