TmCalculator: Melting Temperature of Nucleic Acid Sequences

This tool is extended from methods in Bio.SeqUtils.MeltingTemp of python. The melting temperature of nucleic acid sequences can be calculated in three method, the Wallace rule (Thein & Wallace (1986) <doi:10.1016/S0140-6736(86)90739-7>), empirical formulas based on G and C content (Marmur J. (1962) <doi:10.1016/S0022-2836(62)80066-7>, Schildkraut C. (2010) <doi:10.1002/bip.360030207>, Wetmur J G (1991) <doi:10.3109/10409239109114069>, Untergasser,A. (2012) <doi:10.1093/nar/gks596>, von Ahsen N (2001) <doi:10.1093/clinchem/47.11.1956>) and nearest neighbor thermodynamics (Breslauer K J (1986) <doi:10.1073/pnas.83.11.3746>, Sugimoto N (1996) <doi:10.1093/nar/24.22.4501>, Allawi H (1998) <doi:10.1093/nar/26.11.2694>, SantaLucia J (2004) <doi:10.1146/annurev.biophys.32.110601.141800>, Freier S (1986) <doi:10.1073/pnas.83.24.9373>, Xia T (1998) <doi:10.1021/bi9809425>, Chen JL (2012) <doi:10.1021/bi3002709>, Bommarito S (2000) <doi:10.1093/nar/28.9.1929>, Turner D H (2010) <doi:10.1093/nar/gkp892>, Sugimoto N (1995) <doi:10.1016/S0048-9697(98)00088-6>, Allawi H T (1997) <doi:10.1021/bi962590c>, Santalucia N (2005) <doi:10.1093/nar/gki918>), and it can also be corrected with salt ions and chemical compound (SantaLucia J (1996) <doi:10.1021/bi951907q>, SantaLucia J(1998) <doi:10.1073/pnas.95.4.1460>, Owczarzy R (2004) <doi:10.1021/bi034621r>, Owczarzy R (2008) <doi:10.1021/bi702363u>).

Version:	1.0.3
Depends:	R (≥ 2.10)
Published:	2022-02-21
DOI:	10.32614/CRAN.package.TmCalculator
Author:	Junhui Li
Maintainer:	Junhui Li <junhuili at cau.edu.cn>
BugReports:	https://github.com/JunhuiLi1017/TmCalculator/issues
License:	GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation:	no
CRAN checks:	TmCalculator results

Documentation:

Reference manual:

TmCalculator.html , TmCalculator.pdf

Downloads:

Package source:	TmCalculator_1.0.3.tar.gz
Windows binaries:	r-devel: TmCalculator_1.0.3.zip, r-release: TmCalculator_1.0.3.zip, r-oldrel: TmCalculator_1.0.3.zip
macOS binaries:	r-release (arm64): TmCalculator_1.0.3.tgz, r-oldrel (arm64): TmCalculator_1.0.3.tgz, r-release (x86_64): TmCalculator_1.0.3.tgz, r-oldrel (x86_64): TmCalculator_1.0.3.tgz
Old sources:	TmCalculator archive

Reverse dependencies:

Reverse imports:

ProbeDeveloper

Linking:

Please use the canonical form https://CRAN.R-project.org/package=TmCalculator to link to this page.