A collection of clinical trial designs and methods, implemented in 'rstan' and R, including: the Continual Reassessment Method by O'Quigley et al. (1990) <doi:10.2307/2531628>; EffTox by Thall & Cook (2004) <doi:10.1111/j.0006-341X.2004.00218.x>; the two-parameter logistic method of Neuenschwander, Branson & Sponer (2008) <doi:10.1002/sim.3230>; and the Augmented Binary method by Wason & Seaman (2013) <doi:10.1002/sim.5867>; and more. We provide functions to aid model-fitting and analysis. The 'rstan' implementations may also serve as a cookbook to anyone looking to extend or embellish these models. We hope that this package encourages the use of Bayesian methods in clinical trials. There is a preponderance of early phase trial designs because this is where Bayesian methods are used most. If there is a method you would like implemented, please get in touch.
Version: | 0.1.6 |
Depends: | R (≥ 3.5.0), methods, Rcpp (≥ 1.0.1) |
Imports: | rstan (≥ 2.18.2), rstantools (≥ 1.5.1), rlang (≥ 0.4.5), dplyr, purrr, magrittr, stringr, ggplot2, gtools, coda, tidybayes (≥ 2.0.3), tibble (≥ 3.0.0), binom, MASS |
LinkingTo: | StanHeaders (≥ 2.18.1), rstan (≥ 2.18.2), BH (≥ 1.69.0-1), Rcpp (≥ 1.0.1), RcppEigen (≥ 0.3.3.5.0), RcppParallel (≥ 5.0.2) |
Suggests: | testthat, knitr, rmarkdown, tidyr, ggridges, DiagrammeR |
Published: | 2023-03-12 |
DOI: | 10.32614/CRAN.package.trialr |
Author: | Kristian Brock [aut, cre], Trustees of Columbia University [cph] |
Maintainer: | Kristian Brock <kristian.brock at gmail.com> |
BugReports: | https://github.com/brockk/trialr/issues |
License: | GPL (≥ 3) |
URL: | https://github.com/brockk/trialr |
NeedsCompilation: | yes |
SystemRequirements: | GNU make |
Materials: | README NEWS |
CRAN checks: | trialr results |
Package source: | trialr_0.1.6.tar.gz |
Windows binaries: | r-devel: trialr_0.1.6.zip, r-release: trialr_0.1.6.zip, r-oldrel: trialr_0.1.6.zip |
macOS binaries: | r-release (arm64): trialr_0.1.6.tgz, r-oldrel (arm64): trialr_0.1.6.tgz, r-release (x86_64): trialr_0.1.6.tgz, r-oldrel (x86_64): trialr_0.1.6.tgz |
Old sources: | trialr archive |
Reverse imports: | brms.mmrm, escalation, historicalborrowlong, VisCov |
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