simIDM 0.1.0

New Features

• estimateParams estimates parameters of exponential and Weibull transition hazards using maximum likelihood for a given data set after using prepareData.
• corTrans calculates the correlation between PFS and OS for a given set of transition hazards, and corPFSOS estimates this correlation for a given data set, optionally with a bootstrap based confidence interval.

Bug Fixes

• ExpSurvOS now returns 0 instead of NaN for large values of t.
• WeibSurvOS now does not return an error for large values of t.
• PWCSurvOS now does not return an error for large values of t. It also no longer returns values larger than 1. It is significantly faster, based on a closed form calculation instead of numerical integration.
• getSimulatedData now also works when there are no transitions from progression to death, similarly for getOneClinicalTrial (which now warns if there are no such transitions at all).

Miscellaneous

• PwcOSInt, integrateVector, WeibOSInteg are no longer exported, and only used internally.
• Renamed piecewise constant hazards function to getPWCHazard (previously getPCWHazard).

simIDM 0.0.5

• First CRAN version of the package.
• The package simulates illness-death models with constant, Weibull or piecewise constant transition hazards.

New Features

• Exponentially, Weibull and piecewise exponentially distributed survival times.
• Random censoring and event-driven censoring after a pre-specified number of PFS or OS events.
• Arbitrary number of treatment arms and flexible randomization ratio.
• Staggered study entry.
• Derivation of PFS and OS survival functions from transition hazards.