scSpatialSIM: A Point Pattern Simulator for Spatial Cellular Data

Single cell resolution data has been valuable in learning about tissue microenvironments and interactions between cells or spots. This package allows for the simulation of this level of data, be it single cell or ‘spots’, in both a univariate (single metric or cell type) and bivariate (2 or more metrics or cell types) ways. As more technologies come to marker, more methods will be developed to derive spatial metrics from the data which will require a way to benchmark methods against each other. Additionally, as the field currently stands, there is not a gold standard method to be compared against. We set out to develop an R package that will allow users to simulate point patterns that can be biologically informed from different tissue domains, holes, and varying degrees of clustering/colocalization. The data can be exported as spatial files and a summary file (like 'HALO'). <https://github.com/FridleyLab/scSpatialSIM/>.

Version:	0.1.4
Depends:	R (≥ 4.00)
Imports:	dplyr, ggplot2, magrittr, spatstat.geom, crayon, ggpubr, pbmcapply, spatstat.random, tidyr, utils, methods, proxy
Suggests:	knitr, rmarkdown, testthat (≥ 3.0.0), spatialTIME, spdep
Published:	2026-02-16
DOI:	10.32614/CRAN.package.scSpatialSIM
Author:	Alex Soupir [aut], Christopher Wilson [aut], Jordan Creed [aut], Julia Wrobel [aut], Oscar Ospina [aut], Brooke Fridley [aut, cph], Fridley Lab [cre]
Maintainer:	Fridley Lab <fridley.lab at moffitt.org>
License:	MIT + file LICENSE
URL:	https://github.com/FridleyLab/scSpatialSIM
NeedsCompilation:	no
Materials:	README
CRAN checks:	scSpatialSIM results

Documentation:

Reference manual:	scSpatialSIM.html , scSpatialSIM.pdf
Vignettes:	Introduction (source, R code) Using with spatialTIME (source, R code) Adding Continuous Cell Attributes (source, R code)

Downloads:

Package source:	scSpatialSIM_0.1.4.tar.gz
Windows binaries:	r-devel: scSpatialSIM_0.1.4.zip, r-release: scSpatialSIM_0.1.4.zip, r-oldrel: scSpatialSIM_0.1.4.zip
macOS binaries:	r-release (arm64): scSpatialSIM_0.1.4.tgz, r-oldrel (arm64): scSpatialSIM_0.1.4.tgz, r-release (x86_64): scSpatialSIM_0.1.4.tgz, r-oldrel (x86_64): scSpatialSIM_0.1.4.tgz
Old sources:	scSpatialSIM archive

Reverse dependencies:

Reverse suggests:

spatialGE

Linking:

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