Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2025) <doi:10.1007/978-3-031-89669-9>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.
| Version: |
4.4.0 |
| Depends: |
R (≥ 3.6.0) |
| Imports: |
methods, stats, utils, graphics, tools, rlang, R6 (≥ 2.5.1), knitr (≥ 1.19), Rcpp (≥ 1.0.3) |
| LinkingTo: |
Rcpp |
| Suggests: |
ggplot2 (≥ 3.5.0), testthat (≥ 3.0.0), rmarkdown (≥ 1.10), rappdirs (≥ 0.3.3) |
| Published: |
2026-03-04 |
| DOI: |
10.32614/CRAN.package.rpact |
| Author: |
Gernot Wassmer 
[aut],
Friedrich Pahlke
[aut, cre],
Till Jensen [ctb],
Daniel Sabanes Bove
[ctb],
Stephen Schueuerhuis
[ctb],
Tobias Muetze
[ctb],
RPACT GmbH [cph, fnd] |
| Maintainer: |
Friedrich Pahlke <friedrich.pahlke at rpact.com> |
| BugReports: |
https://github.com/rpact-com/rpact/issues |
| License: |
LGPL-3 |
| URL: |
https://www.rpact.org, https://www.rpact.com,
https://docs.rpact.org, https://github.com/rpact-com/rpact,
https://rpact-cloud.share.connect.posit.cloud |
| NeedsCompilation: |
yes |
| Language: |
en-US |
| Citation: |
rpact citation info |
| Materials: |
README, NEWS |
| In views: |
ClinicalTrials |
| CRAN checks: |
rpact results |