replicateBE: Average Bioequivalence with Expanding Limits (ABEL)
Performs comparative bioavailability calculations for Average Bioequivalence with Expanding Limits (ABEL). Implemented are 'Method A' / 'Method B' and the detection of outliers. If the design allows, assessment of the empiric Type I Error and iteratively adjusting alpha to control the consumer risk. Average Bioequivalence - optionally with a tighter (narrow therapeutic index drugs) or wider acceptance range (South Africa: Cmax) - is implemented as well.
| Version: | 1.1.3 |
| Depends: | R (≥ 3.5.0) |
| Imports: | readxl (≥ 1.0.0), PowerTOST (≥ 1.5.3), lmerTest, nlme, pbkrtest, graphics, grDevices |
| Suggests: | knitr, rmarkdown, testthat, devtools |
| Published: | 2022-05-02 |
| DOI: | 10.32614/CRAN.package.replicateBE |
| Author: | Helmut Schütz 
[aut, cre],
Michael Tomashevskiy [ctb],
Detlew Labes
[ctb] |
| Maintainer: | Helmut Schütz <helmut.schuetz at bebac.at> |
| BugReports: | https://github.com/Helmut01/replicateBE/issues |
| License: | GPL (≥ 3) |
| URL: | https://github.com/Helmut01/replicateBE |
| NeedsCompilation: | no |
| Materials: | README, NEWS |
| In views: | ClinicalTrials, Pharmacokinetics |
| CRAN checks: | replicateBE results |
Documentation:
| Reference manual: | replicateBE.html , replicateBE.pdf |
| Vignettes: |
replicateBE (source, R code) |
Downloads:
| Package source: | replicateBE_1.1.3.tar.gz |
| Windows binaries: | r-devel: replicateBE_1.1.3.zip, r-release: replicateBE_1.1.3.zip, r-oldrel: replicateBE_1.1.3.zip |
| macOS binaries: | r-release (arm64): replicateBE_1.1.3.tgz, r-oldrel (arm64): replicateBE_1.1.3.tgz, r-release (x86_64): replicateBE_1.1.3.tgz, r-oldrel (x86_64): replicateBE_1.1.3.tgz |
| Old sources: | replicateBE archive |
Linking:
Please use the canonical form https://CRAN.R-project.org/package=replicateBE to link to this page.