Computes noncompartmental pharmacokinetic parameters for drug concentration profiles. For each profile, data imputations and adjustments are made as necessary and basic parameters are estimated. Supports single dose, multi-dose, and multi-subject data. Supports steady-state calculations and various routes of drug administration. See ?qpNCA and vignettes. Methodology follows Rowland and Tozer (2011, ISBN:978-0-683-07404-8), Gabrielsson and Weiner (1997, ISBN:978-91-9765-100-4), and Gibaldi and Perrier (1982, ISBN:978-0824710422).
| Version: | 1.1.6 |
| Depends: | R (≥ 3.3.0) |
| Imports: | dplyr (≥ 0.7.0), tidyr (≥ 0.8.2), magrittr, ggplot2, knitr |
| Suggests: | rmarkdown, markdown, covr, testthat (≥ 2.1.0) |
| Published: | 2021-08-16 |
| DOI: | 10.32614/CRAN.package.qpNCA |
| Author: | Jan Huisman [aut, cre], Koen Jolling [ctb], Krina Mehta [ctb], Tim Bergsma [ctb] |
| Maintainer: | Jan Huisman <jan.huisman at qpharmetra.com> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| Materials: | README |
| In views: | MissingData, Pharmacokinetics |
| CRAN checks: | qpNCA results |
| Reference manual: | qpNCA.html , qpNCA.pdf |
| Vignettes: |
Parameter Guidelines (source) A User Guide for qpNCA (source) Example Full NCA Analysis (source, R code) Example Stepwise NCA Analysis (source, R code) |
| Package source: | qpNCA_1.1.6.tar.gz |
| Windows binaries: | r-devel: qpNCA_1.1.6.zip, r-release: qpNCA_1.1.6.zip, r-oldrel: qpNCA_1.1.6.zip |
| macOS binaries: | r-release (arm64): qpNCA_1.1.6.tgz, r-oldrel (arm64): qpNCA_1.1.6.tgz, r-release (x86_64): qpNCA_1.1.6.tgz, r-oldrel (x86_64): qpNCA_1.1.6.tgz |
| Old sources: | qpNCA archive |
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