pmxNODE: Application of NODEs in 'Monolix', 'NONMEM', and 'nlmixr2'

An easy-to-use tool for implementing Neural Ordinary Differential Equations (NODEs) in pharmacometric software such as 'Monolix', 'NONMEM', and 'nlmixr2', see Bräm et al. (2024) <doi:10.1007/s10928-023-09886-4> and Bräm et al. (2025) <doi:10.1002/psp4.13265>. The main functionality is to automatically generate structural model code describing computations within a neural network. Additionally, parameters and software settings can be initialized automatically. For using these additional functionalities with 'Monolix', 'pmxNODE' interfaces with 'MonolixSuite' via the 'lixoftConnectors' package. The 'lixoftConnectors' package is distributed with 'MonolixSuite' (<https://monolixsuite.slp-software.com/r-functions/2024R1/package-lixoftconnectors>) and is not available from public repositories.

Version:	0.1.0
Imports:	tidyr, ggplot2, checkmate
Suggests:	rxode2, nlmixr2, lixoftConnectors, withr, testthat (≥ 3.0.0), knitr, rmarkdown
Published:	2025-11-26
DOI:	10.32614/CRAN.package.pmxNODE
Author:	Dominic Bräm [aut, cre], Bernhard Steiert [ctb], Gilbert Koch [ctb], Matthew Fidler [ctb]
Maintainer:	Dominic Bräm <domi.braem at hotmail.com>
BugReports:	https://github.com/braemd/pmxNODE/issues
License:	GPL (≥ 3)
NeedsCompilation:	no
Citation:	pmxNODE citation info
Materials:	README
CRAN checks:	pmxNODE results

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