pkpd.Release: Model Fitting and Simulation for Drug Release Kinetics and PK/PD
Provides a comprehensive framework for model fitting and simulation
of drug release kinetics, pharmacokinetics (PK), and pharmacodynamics (PD).
The package implements widely used mechanistic and empirical models for in
vitro drug release, including zero-order, first-order, Higuchi,
Korsmeyer-Peppas, Hixson-Crowell, and Weibull models. Pharmacokinetic
functionality includes linear and nonlinear functions for one- and
two-compartment models for intravenous bolus and oral administration,
Michaelis-Menten kinetics, and non-compartmental analysis (NCA).
Pharmacodynamic and dose-response modeling is supported through Emax-based
models, including stimulatory (sigmoid Emax) and inhibitory (sigmoid Imax)
Hill models, four- and five-parameter logistic models, as well as median
toxic dose (TD50) and lethal dose (LD50) models. The package is intended to
support parameter estimation, simulation, and model comparison in
pharmaceutical research, drug development, and pharmacometrics education.
For more details, see Gabrielsson & Weiner (2000) <ISBN:9186274929>,
Holford & Sheiner (1981) <doi:10.2165/00003088-198106060-00002>, and
Manlapaz (2025) <doi:10.32614/CRAN.package.adsoRptionCMF>.
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