mmcm package

Modified Maximum Contrast Method

An implementation of modified maximum contrast methods and the maximum contrast method: Functions ‘mmcm.mvt’ and ‘mcm.mvt’ give P-value by using randomized quasi-Monte Carlo method with ‘pmvt’ function of package ‘mvtnorm’, and ‘mmcm.resamp’ gives P-value by using a permutation method.

• Sato Y, Laird NM, Nagashima K, et al. A new statistical screening approach for finding pharmacokinetics-related genes in genome-wide studies. The Pharmacogenomics Journal 2009; 9(2): 137–146. doi:10.1038/tpj.2008.17.
• Nagashima K, Sato Y, Hamada C. A modified maximum contrast method for unequal sample sizes in pharmacogenomic studies. Statistical Applications in Genetics and Molecular Biology 2011; 10(1): Article 41. doi:10.2202/1544-6115.1560.
• Yoshimura I, Wakana A, Hamada C. A performance comparison of maximum contrast methods to detect dose dependency. Drug Informatoion Journal 1997; 31(2): 423–432. doi:10.1177/009286159703100213.

Installation

Get the released version from CRAN:

install.packages("mmcm")

Or the development version from github:

# install.packages("devtools")
devtools::install_github("nshi-stat/mmcm")