invivoPKfit 2.0.2

• Minor bug fix for adjusting rate constants after fitting to standard “1/hour”.
  
• Improved pk object organization and CLI message outputs.
  
• Externalized parallel processing for fitting with mirai and purrr 1.1.0. Now, users should set the number of processes through those interfaces if parallel or distributed computing is desired.
  
• Setting data, error, NCA, sd, and LOQ groups now uses unquoted data variable names, the latter two have their own separate pkproto object setups: stat_sd_group() and stat_loq_group().
  
• Parameter starts and and estimates are stored as singular values in a list-column, which allows character vector constant parameters for calls to more complex PBTK models, see model_httk_gas_pbtk.
  
• Users may now set specific parameters to optimize and specific start values using the new functions set_params_optimize() and set_params_starts().
• Updated cvt object to align with latest CvTdb release.

invivoPKfit 2.0.1

• Ensured only optimized parameters will be used when calculating AIC. This is really only a concern when using models that hold many of the total parameters constant.
  
• Added a new feature allowing users to calculate log-likelihood from predictions generated outside invivoPKfit.
  
• Updated documentation and cleaned up vignettes.

invivoPKfit 2.0.0

• Initial CRAN submission.
  
• Redesigned package to an S3 object-oriented approach with some ggplot2-like syntax.
  
• Re-factored function/method code to ensure the code base is more legible to future contributors.
  
• Implemented messages that save and update data processing “status”.
  
• Parallel processing parameter optimization was added as an option to take advantage of multi-processing cores.
  
• Included more chemical records than previously published in the cvt object, represented a processed portion of the CvTdb database.