cwot: Cauchy Weighted Joint Test for Pharmacogenetics Analysis

A flexible and robust joint test of the single nucleotide polymorphism (SNP) main effect and genotype-by-treatment interaction effect for continuous and binary endpoints. Two analytic procedures, Cauchy weighted joint test (CWOT) and adaptively weighted joint test (AWOT), are proposed to accurately calculate the joint test p-value. The proposed methods are evaluated through extensive simulations under various scenarios. The results show that the proposed AWOT and CWOT control type I error well and outperform existing methods in detecting the most interesting signal patterns in pharmacogenetics (PGx) association studies. For reference, see Hong Zhang, Devan Mehrotra and Judong Shen (2022) <doi:10.13140/RG.2.2.28323.53280>.

Version:	0.1.0
Imports:	stats, SPAtest, mvtnorm
Published:	2022-09-23
DOI:	10.32614/CRAN.package.cwot
Author:	Hong Zhang [aut, cre]
Maintainer:	Hong Zhang <hzhang at wpi.edu>
License:	GPL-2
NeedsCompilation:	no
CRAN checks:	cwot results

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