Implements the conditionally symmetric multidimensional Gaussian mixture model (csmGmm) for large-scale testing of composite null hypotheses in genetic association applications such as mediation analysis, pleiotropy analysis, and replication analysis. In such analyses, we typically have J sets of K test statistics where K is a small number (e.g. 2 or 3) and J is large (e.g. 1 million). For each one of the J sets, we want to know if we can reject all K individual nulls. Please see the vignette for a quickstart guide. The paper describing these methods is "Testing a Large Number of Composite Null Hypotheses Using Conditionally Symmetric Multidimensional Gaussian Mixtures in Genome-Wide Studies" by Sun R, McCaw Z, & Lin X (Journal of the American Statistical Association 2025, <doi:10.1080/01621459.2024.2422124>).
| Version: | 0.4.0 |
| Imports: | dplyr, mvtnorm, rlang, magrittr |
| Suggests: | knitr, rmarkdown |
| Published: | 2025-09-16 |
| DOI: | 10.32614/CRAN.package.csmGmm |
| Author: | Ryan Sun [aut, cre] |
| Maintainer: | Ryan Sun <ryansun.work at gmail.com> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| Materials: | README |
| CRAN checks: | csmGmm results |
| Reference manual: | csmGmm.html , csmGmm.pdf |
| Vignettes: |
Tutorial (source, R code) |
| Package source: | csmGmm_0.4.0.tar.gz |
| Windows binaries: | r-devel: csmGmm_0.4.0.zip, r-release: csmGmm_0.4.0.zip, r-oldrel: csmGmm_0.4.0.zip |
| macOS binaries: | r-release (arm64): csmGmm_0.4.0.tgz, r-oldrel (arm64): csmGmm_0.4.0.tgz, r-release (x86_64): csmGmm_0.4.0.tgz, r-oldrel (x86_64): csmGmm_0.4.0.tgz |
| Old sources: | csmGmm archive |
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