The goal of bfboin is to provide an independent implementation of the BF-BOIN design of Zhou et al. (2024), aiming to reproduce the functionality of the shiny app by MD Anderson.
Zhao, Y., Yuan, Y., Korn, E.L. and Freidlin, B., 2024. Backfilling patients in phase I dose-escalation trials using Bayesian optimal interval design (BOIN). Clinical Cancer Research, 30(4), pp.673-679.
You can install the development version of bfboin like so:
# install.packages("devtools")
devtools::install_github("openpharma/bfboin")library(bfboin)
## basic example code
get.oc.bf(ntrial = 100,
seed = 9,
target = 0.25,
p.true = c(0.1, 0.5),
ncohort = 10,
cohortsize = 3,
n.earlystop = 9,
startdose = 1,
titration = FALSE,
cutoff.eli = 0.95,
extrasafe = TRUE,
offset = 0.1,
boundMTD=FALSE,
n.cap = 12,
end.backfill = TRUE,
n.per.month = 1,
dlt.window = 1,
p.response.true = c(0.001, 0.001),
accrual = "uniform")
#> $selpercent
#> [1] 75 18
#>
#> $npatients
#> 1 2
#> 10.54 7.41
#>
#> $percentpatients
#> 1 2
#> 58.71866 41.28134
#>
#> $ntox
#> 1 2
#> 1.01 3.71
#>
#> $totaltox
#> [1] 4.72
#>
#> $totaln
#> [1] 17.95
#>
#> $percentstop
#> [1] 7
#>
#> $duration
#> [1] 20.52315
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