Two-stage design for single-arm phase II trials with time-to-event endpoints (e.g., clinical trials on immunotherapies among cancer patients) can be calculated using this package. Two notable advantages of the package: 1) It provides flexible choices from three design methods (optimal, minmax, and admissible), and 2) the power of the design is more accurately calculated using the exact variance in the one-sample log-rank test. The package can be used for 1) planning the sample sizes and other design parameters, and 2) conducting the interim and final analyses for the Go/No-go decisions. More details about the design method can be found in: Wu, J, Chen L, Wei J, Weiss H, Chauhan A. (2020). <doi:10.1002/pst.1983>.
| Version: | 1.2.1 |
| Depends: | R (≥ 3.5.0) |
| Imports: | survival, utils, flexsurv, IPDfromKM |
| Suggests: | knitr, rmarkdown, testthat (≥ 3.0.0) |
| Published: | 2023-10-09 |
| DOI: | 10.32614/CRAN.package.OneArm2stage |
| Author: | Xiaomeng Yuan [aut, cre], Haitao Pan [aut], Jianrong Wu [aut] |
| Maintainer: | Xiaomeng Yuan <xiaomeng.yuan at stjude.org> |
| License: | GPL (≥ 3) |
| NeedsCompilation: | no |
| Materials: | NEWS |
| CRAN checks: | OneArm2stage results |
| Reference manual: | OneArm2stage.html , OneArm2stage.pdf |
| Vignettes: |
OneArm2stage (source, R code) |
| Package source: | OneArm2stage_1.2.1.tar.gz |
| Windows binaries: | r-devel: OneArm2stage_1.2.1.zip, r-release: OneArm2stage_1.2.1.zip, r-oldrel: OneArm2stage_1.2.1.zip |
| macOS binaries: | r-release (arm64): OneArm2stage_1.2.1.tgz, r-oldrel (arm64): OneArm2stage_1.2.1.tgz, r-release (x86_64): OneArm2stage_1.2.1.tgz, r-oldrel (x86_64): OneArm2stage_1.2.1.tgz |
| Old sources: | OneArm2stage archive |
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