MAnorm2: Tools for Normalizing and Comparing ChIP-seq Samples
Chromatin immunoprecipitation followed by high-throughput
sequencing (ChIP-seq) is the premier technology for profiling genome-wide
localization of chromatin-binding proteins, including transcription
factors and histones with various modifications.
This package provides a robust method for normalizing ChIP-seq
signals across individual samples or groups of samples. It also designs
a self-contained system of statistical models for calling differential
ChIP-seq signals between two or more biological conditions as well as
for calling hypervariable ChIP-seq signals across samples. Refer to
Tu et al. (2021) <doi:10.1101/gr.262675.120> and
Chen et al. (2022) <doi:10.1186/s13059-022-02627-9>
for associated statistical details.
| Version: |
1.2.2 |
| Depends: |
R (≥ 3.5.0) |
| Imports: |
stats, graphics, methods, locfit (≥ 1.5.9), scales (≥
0.3.0), statmod (≥ 1.4.34) |
| Suggests: |
gplots (≥ 3.0.1), DescTools (≥ 0.99.24), knitr, rmarkdown |
| Published: |
2022-10-28 |
| DOI: |
10.32614/CRAN.package.MAnorm2 |
| Author: |
Shiqi Tu  [aut,
cre] |
| Maintainer: |
Shiqi Tu <tushiqi at picb.ac.cn> |
| BugReports: |
https://github.com/tushiqi/MAnorm2/issues |
| License: |
GPL-3 |
| URL: |
https://github.com/tushiqi/MAnorm2 |
| NeedsCompilation: |
no |
| Citation: |
MAnorm2 citation info |
| Materials: |
README, NEWS |
| CRAN checks: |
MAnorm2 results |
Documentation:
Downloads:
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