LocalControl: Nonparametric Methods for Generating High Quality Comparative Effectiveness Evidence

Implements novel nonparametric approaches to address biases and confounding when comparing treatments or exposures in observational studies of outcomes. While designed and appropriate for use in studies involving medicine and the life sciences, the package can be used in other situations involving outcomes with multiple confounders. The package implements a family of methods for non-parametric bias correction when comparing treatments in observational studies, including survival analysis settings, where competing risks and/or censoring may be present. The approach extends to bias-corrected personalized predictions of treatment outcome differences, and analysis of heterogeneity of treatment effect-sizes across patient subgroups. For further details, please see: Lauve NR, Nelson SJ, Young SS, Obenchain RL, Lambert CG. LocalControl: An R Package for Comparative Safety and Effectiveness Research. Journal of Statistical Software. 2020. p. 1–32. Available from <doi:10.18637/jss.v096.i04>.

Version:	1.1.7
Depends:	R (≥ 3.0.0)
Imports:	Rcpp, gss, cluster, lattice, stats, graphics
LinkingTo:	Rcpp
Suggests:	colorspace, RColorBrewer, data.table, ggplot2, gridExtra, rpart, rpart.plot, xtable, R.rsp
Published:	2026-03-04
DOI:	10.32614/CRAN.package.LocalControl
Author:	Nicolas R. Lauve [aut], Stuart J. Nelson [aut], S. Stanley Young [aut], Robert L. Obenchain [aut], Melania Pintilie [ctb], Martin Kutz [ctb], Christophe G. Lambert [aut, cre]
Maintainer:	Christophe G. Lambert <cglambert at salud.unm.edu>
BugReports:	https://github.com/OHDSI/LocalControl/issues
License:	Apache License 2.0 | file LICENSE
URL:	https://github.com/OHDSI/LocalControl
NeedsCompilation:	yes
Citation:	LocalControl citation info
Materials:	README, NEWS
CRAN checks:	LocalControl results

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