InsuSensCalc 0.0.1 (2024-04-02)

• Initial release of the InsuSensCalc, featuring the isi_calculator function.

New Features

• isi_calculator Function: A comprehensive tool for calculating surrogate insulin sensitivity indices based on various measurements, including fasting, Oral Glucose Tolerance Test (OGTT), and lipid (adipose) values. This function supports a wide range of indices calculations, making it a versatile tool for research in metabolic health and diabetes.

Capabilities

• Calculates indices using fasting glucose and insulin levels, including:
  • Fasting Insulin Sensitivity
  • HOMA-IR (and its inverse)
  • QUICKI
  • And several other fasting-related indices.
• Incorporates OGTT (0 min, 30 min, 120 min post-glucose load) values for:
  • Gutt Index
  • Matsuda Index
  • Insulin Sensitivity Index at 120 min
  • And more, adapting calculations based on available time points.
• Utilizes lipid (adipo) measurements like triglycerides, free fatty acids and HDL cholesterol for indices such as:
  • Visceral Adiposity Index (VAI) for Men and Women (inversed)
  • Lipid Accumulation Product (LAP)
  • ATIRI_inv
• Utilizes tracer and dxa based data measurements like rate of glycerol, palmitate and dxa based fat mass for indices such as:
  • LIRI_inv
  • Lipo_inv
  • TyG Index (inversed)
  • And other adipose-related indices.

Flexible Input

• The function accepts a dataframe containing the necessary variables for calculation and a character vector specifying the categories of indices to calculate ("fasting", "ogtt", "adipo"), allowing users to customize the scope of their analysis.

User-friendly

• Includes comprehensive documentation and examples to facilitate easy use and integration into research workflows.

This release lays the foundation for robust and flexible insulin sensitivity analysis within the R ecosystem, catering to a wide array of research needs in metabolic health.