The DoseFinding package provides functions for the design and analysis
of dose-finding experiments (with focus on pharmaceutical Phase
II clinical trials). It provides functions for: multiple contrast
tests, fitting non-linear dose-response models (using Bayesian and
non-Bayesian estimation), calculating optimal designs and an
implementation of the MCPMod methodology (Pinheiro et al. (2014)
<doi:10.1002/sim.6052>).
| Version: |
1.4-1 |
| Imports: |
ggplot2, lattice, mvtnorm |
| Suggests: |
emmeans, numDeriv, Rsolnp, quadprog, parallel, mmrm, multcomp, knitr, rmarkdown, MASS, testthat (≥ 3.0.0), tibble, RBesT, nlme, dplyr, tidyr |
| Published: |
2025-07-09 |
| DOI: |
10.32614/CRAN.package.DoseFinding |
| Author: |
Bjoern Bornkamp 
[aut],
Jose Pinheiro [aut],
Frank Bretz [aut],
Ludger Sandig [aut],
Marius Thomas [aut, cre],
Daniel Sabanes Bove
[aut],
Novartis Pharma AG [cph, fnd] |
| Maintainer: |
Marius Thomas <marius.thomas at novartis.com> |
| BugReports: |
https://github.com/openpharma/DoseFinding/issues |
| License: |
GPL-3 |
| URL: |
https://github.com/openpharma/DoseFinding,
https://openpharma.github.io/DoseFinding/ |
| NeedsCompilation: |
yes |
| Materials: |
README, NEWS |
| In views: |
ClinicalTrials, ExperimentalDesign |
| CRAN checks: |
DoseFinding results |