Implements the DANDELION method for prioritizing candidate disease-related proximal genes by integrating trans-regulatory association p-values and gene-level trait association p-values. The statistical testing framework builds on the divide-aggregate composite-null test described by Liu et al. (2022) <doi:10.1080/01621459.2021.1914634>. The biological application and SNP/gene-based prioritization workflow are motivated by Salamone et al. (under review), "Leveraging trans-gene regulation prioritizes central genes and pathways in asthma". The package provides functions for identifying distal-proximal gene pairs, organizing significant pairs into genomic loci, and visualizing resulting gene networks.
| Version: | 0.1.0 |
| Imports: | igraph |
| Suggests: | qvalue |
| Published: | 2026-05-04 |
| DOI: | 10.32614/CRAN.package.DANDELION |
| Author: | Peixin Tian [aut, cre] |
| Maintainer: | Peixin Tian <pxtian at connect.hku.hk> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| Additional_repositories: | https://bioconductor.org/packages/release/bioc |
| CRAN checks: | DANDELION results |
| Reference manual: | DANDELION.html , DANDELION.pdf |
| Package source: | DANDELION_0.1.0.tar.gz |
| Windows binaries: | r-devel: DANDELION_0.1.0.zip, r-release: DANDELION_0.1.0.zip, r-oldrel: DANDELION_0.1.0.zip |
| macOS binaries: | r-release (arm64): DANDELION_0.1.0.tgz, r-oldrel (arm64): DANDELION_0.1.0.tgz, r-release (x86_64): DANDELION_0.1.0.tgz, r-oldrel (x86_64): DANDELION_0.1.0.tgz |
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