Certara.RsNLME: Pharmacometric Modeling

Facilitate Pharmacokinetic (PK) and Pharmacodynamic (PD) modeling and simulation with powerful tools for Nonlinear Mixed-Effects (NLME) modeling. The package provides access to the same advanced Maximum Likelihood algorithms used by the NLME-Engine in the Phoenix platform. These tools support a range of analyses, from parametric methods to individual and pooled data, and support integrated use within the Pirana pharmacometric workbench <doi:10.1002/psp4.70067>. Execution is supported both locally or on remote machines.

Version:	3.1.0.1
Depends:	R (≥ 4.0)
Imports:	xml2, assertthat, Certara.NLME8, data.table, jsonlite, methods, utils, ssh
Suggests:	rlang, knitr, rmarkdown, testthat, magrittr
Published:	2025-09-03
DOI:	10.32614/CRAN.package.Certara.RsNLME
Author:	James Craig [aut, cre], Michael Tomashevskiy [aut], Vitalii Nazarov [aut], Shuhua Hu [ctb], Soltanshahi Fred [aut], Certara USA, Inc. [cph, fnd]
Maintainer:	James Craig <james.craig at certara.com>
License:	LGPL-3
URL:	https://certara.github.io/R-RsNLME/
NeedsCompilation:	no
Materials:	README
CRAN checks:	Certara.RsNLME results

Documentation:

Reference manual:

Certara.RsNLME.html , Certara.RsNLME.pdf

Downloads:

Package source:	Certara.RsNLME_3.1.0.1.tar.gz
Windows binaries:	r-devel: Certara.RsNLME_3.1.0.1.zip, r-release: Certara.RsNLME_3.1.0.1.zip, r-oldrel: Certara.RsNLME_3.1.0.1.zip
macOS binaries:	r-release (arm64): Certara.RsNLME_3.1.0.1.tgz, r-oldrel (arm64): Certara.RsNLME_3.1.0.1.tgz, r-release (x86_64): Certara.RsNLME_3.1.0.1.tgz, r-oldrel (x86_64): Certara.RsNLME_3.1.0.1.tgz
Old sources:	Certara.RsNLME archive

Reverse dependencies:

Reverse imports:	Certara.RsNLME.ModelBuilder, Certara.RsNLME.ModelExecutor
Reverse suggests:	Certara.ModelResults, Certara.RDarwin, Certara.Xpose.NLME

Linking:

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