A method for finding enrichments of somatic single nucleotide variants (SNVs) and small insertions-deletions (Indels) in functional elements in the human genome. 'ActiveDriverWGS' detects coding and noncoding cancer driver elements using whole genome sequencing data. The method is part of the publication H. Zhu et al. (2020) <doi:10.1016/j.molcel.2019.12.027> "Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks" in Molecular Cell.
| Version: | 1.2.1 |
| Depends: | R (≥ 3.5) |
| Imports: | BSgenome, Biostrings, GenomeInfoDb, GenomicRanges, IRanges, S4Vectors |
| Suggests: | BSgenome.Hsapiens.UCSC.hg19, BSgenome.Hsapiens.UCSC.hg38, BSgenome.Mmusculus.UCSC.mm9, BSgenome.Mmusculus.UCSC.mm10, knitr, testthat, rmarkdown |
| Published: | 2026-03-13 |
| DOI: | 10.32614/CRAN.package.ActiveDriverWGS |
| Author: | Juri Reimand [aut, cre], Helen Zhu [ctb], Kevin Cheng [ctb] |
| Maintainer: | Juri Reimand <juri.reimand at utoronto.ca> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| Materials: | README, NEWS |
| CRAN checks: | ActiveDriverWGS results |
| Reference manual: | ActiveDriverWGS.html , ActiveDriverWGS.pdf |
| Vignettes: |
ActiveDriverWGS (source, R code) |
| Package source: | ActiveDriverWGS_1.2.1.tar.gz |
| Windows binaries: | r-devel: ActiveDriverWGS_1.2.1.zip, r-release: not available, r-oldrel: ActiveDriverWGS_1.2.1.zip |
| macOS binaries: | r-release (arm64): ActiveDriverWGS_1.2.1.tgz, r-oldrel (arm64): ActiveDriverWGS_1.2.1.tgz, r-release (x86_64): ActiveDriverWGS_1.2.1.tgz, r-oldrel (x86_64): not available |
| Old sources: | ActiveDriverWGS archive |
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