GPU-Portable Pairwise Sequence Alignment (WFA + Smith-Waterman) R package genoaligner version 1.0.0 Pairwise sequence alignment from one portable C++17 core: edit-distance (Levenshtein / WFA-equivalent) and Smith-Waterman local alignment, both with score and CIGAR reconstruction. The core builds and runs anywhere (it is the CPU backend, so it needs no GPU toolchain); the wavefront/GPU backend (ROCm/CUDA) computes the same results with acceleration and is tracked in the sibling C++ repository. A batch API aligns many pairs in one call and reports how many were resolved, so silent under-serving is impossible. Designed to slot into data.frame/tibble pipelines. Software Depends: R (>= 4.1.0) Imports: Rcpp LinkingTo: Rcpp Suggests: testthat (>= 3.0.0), knitr, rmarkdown, spelling Angel Robles-Fernandez <a.l.robles.fernandez@gmail.com> Comprehensive R Archive Network (CRAN) Angel Robles-Fernandez [aut, cre] MIT + file LICENSE (https://CRAN.R-project.org/package=genoaligner/LICENSE) 2026-09-24 application/tgz https://CRAN.R-project.org/package=genoaligner doi:10.32614/CRAN.package.genoaligner en-US