<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Kernel-Weighted Cox Regression for Treatment Effect
Heterogeneity</dc:title>
  <dc:title>R package chestR version 0.1.0</dc:title>
  <dc:description>Explores treatment effect heterogeneity and candidate predictive
    biomarkers by re-fitting weighted Cox proportional hazards models on a
    biomarker grid. Kernel weights centred at each grid point produce local
    coefficient estimates that can be visualised across biomarker space.  
    Builds on ideas related to graphical Cox treatment-covariate interaction 
    methods [see Bonetti and Gelber (2004) &lt;doi:10.1093/biostatistics/kxh002&gt; and
    local partial-likelihood approaches Fan, Lin and Zhou (2006)
    &lt;doi:10.1214/009053605000000796&gt;].</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Imports: survival, ggplot2, scales</dc:relation>
  <dc:relation>Suggests: knitr, rmarkdown, mvtnorm, testthat (&gt;= 3.0.0)</dc:relation>
  <dc:creator>Richard Jackson &lt;richj23@liverpool.ac.uk&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Richard Jackson [aut, cre],
  Caroline Jeffery [aut]</dc:contributor>
  <dc:rights>MIT + file LICENSE (https://CRAN.R-project.org/package=chestR/LICENSE)</dc:rights>
  <dc:date>2026-09-12</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=chestR</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.chestR</dc:identifier>
  <dc:language>en-GB</dc:language>
</oai_dc:dc>
