Sample Size Calculations for Epidemiological, Clinical, and Diagnostic Studies R package SampleSizeR version 0.1.0 Provides comprehensive methods for sample size determination for epidemiological studies, clinical trials, diagnostic accuracy studies, and diagnostic agreement studies. The package supports prevalence surveys, cluster prevalence studies, unmatched case-control studies, cohort studies, superiority, non-inferiority, and equivalence clinical trials, diagnostic sensitivity, diagnostic specificity, receiver operating characteristic (ROC) area under the curve (AUC), and diagnostic agreement studies. Functions include optional adjustments for finite population correction, design effect, unequal allocation, anticipated response rate, and dropout. Results are returned as standardized 'SampleSizeR' objects with print, summary, plot, and data frame methods. Software Depends: R (>= 4.2.0) Imports: stats, ggplot2, rlang Suggests: testthat (>= 3.0.0), knitr, rmarkdown, covr Vinodh Kumar Obli Rajendran <vinodhkumar.rajendran@gmail.com> Comprehensive R Archive Network (CRAN) Vinodh Kumar Obli Rajendran [aut, cre], Keerthi Aaradhana [aut] GPL-3 2026-08-05 application/tgz https://CRAN.R-project.org/package=SampleSizeR doi:10.32614/CRAN.package.SampleSizeR en-US