Penalized Semiparametric Bayesian Cox Models

This is a C++ speed-up and extended version of the R-package psbcGroup. It implements the Bayesian Lasso Cox model (Lee et al., 2011) and the Bayesian Lasso Cox with mandatory variables (Zucknick et al., 2015). Bayesian Lasso Cox models with other shrinkage and group priors (Lee et al., 2015) are to be implemented later on.

Examples

Run a Bayesian Lasso Cox with mandatory variables

Data set exampleData consists of six components: survival times t, event status di, covariates x, number of genomics variables p, number of clinical variables q and true effects of covariates beta_true. See ?exampleData for more information of the data.

To run a Bayesian Lasso Cox model for variable selection of the first $p$ genomics variables and inclusion of $q$ mandatory variables, one can specify arguments of the main function psbcSpeedUp() with p = p and q = q. If the arguments p and q are unspecified, the Bayesian Lasso Cox model does variable selection for all covariates, i.e., by default p = ncol(survObj$x) and q = 0.

# Load the example dataset
data("exampleData", package = "psbcSpeedUp")
p <- exampleData$p
q <- exampleData$q
survObj <- exampleData[1:3]

# Set hyperparameters (see help file for specifying more hyperparameters)
mypriorPara <- list(
  "eta0" = 0.02, "kappa0" = 1, "c0" = 2, "r" = 10 / 9, "delta" = 1e-05,
  "lambdaSq" = 1, "sigmaSq" = runif(1, 0.1, 10), "beta.prop.var" = 1, "beta.clin.var" = 1
)

# run Bayesian Lasso Cox
library("psbcSpeedUp")
set.seed(123)
fitBayesCox <- psbcSpeedUp(survObj,
  p = p, q = q, hyperpar = mypriorPara,
  nIter = 1000, burnin = 500, outFilePath = "/tmp"
)

Plot posterior estimates of regression coefficients

The function psbcSpeedUp::plot() can show the posterior mean and 95% credible intervals of regression coefficients.

plot(fitBayesCox)

Plot time-dependent Brier scores

The function psbcSpeedUp::plotBrier() can show the time-dependent Brier scores based on posterior mean of coefficients or Bayesian model averaging.

plotBrier(fitBayesCox, times = 80)

##     Null.model Bayesian.Cox
## IBS  0.2089742   0.08276646

Predict survival probabilities and cumulative hazards

The function psbcSpeedUp::predict() can estimate the survival probabilities and cumulative hazards.

predict(fitBayesCox, type = c("cumhazard", "survival"))

##        observation   times cumhazard  survival
##              <int>   <num>     <num>     <num>
##     1:           1   0.264  8.39e-06  1.00e+00
##     2:           2   0.264  4.09e-05  1.00e+00
##     3:           3   0.264  4.84e-05  1.00e+00
##     4:           4   0.264  2.44e-05  1.00e+00
##     5:           5   0.264  7.22e-05  1.00e+00
##    ---                                        
## 39996:         196 107.641  2.18e+00  1.14e-01
## 39997:         197 107.641  6.28e-01  5.34e-01
## 39998:         198 107.641  4.95e+01  3.15e-22
## 39999:         199 107.641  4.17e+02 9.71e-182
## 40000:         200 107.641  3.00e-01  7.41e-01