Administration          Administration
AdministrationConstraints
                        AdministrationConstraints
Arm                     Arm
BayesianFim             BayesianFim
Combined1               Combined1
Constant                Constant
Dcriterion              Dcriterion: get the D-criterion of the Fim.
Design                  Design
Distribution            Distribution
Evaluation              Evaluation
FedorovWynnAlgorithm    FedorovWynnAlgorithm
FedorovWynnAlgorithm_Rcpp
                        Fedorov-Wynn algorithm in Rcpp.
Fim                     Fim
IndividualFim           IndividualFim
LibraryOfModels         LibraryOfModels
LibraryOfPDModels       LibraryOfPDModels
LibraryOfPKModels       LibraryOfPKModels
Linear2BolusSingleDose_ClQV1V2
                        Model Linear2BolusSingleDose_ClQV1V2
Linear2BolusSingleDose_kk12k21V
                        Model Linear2BolusSingleDose_kk12k21V
Linear2BolusSteadyState_ClQV1V2tau
                        Model Linear2BolusSteadyState_ClQV1V2tau
Linear2BolusSteadyState_kk12k21Vtau
                        Model Linear2BolusSteadyState_kk12k21Vtau
Linear2FirstOrderSingleDose_kaClQV1V2
                        Model Linear2FirstOrderSingleDose_kaClQV1V2
Linear2FirstOrderSingleDose_kakk12k21V
                        Model Linear2FirstOrderSingleDose_kakk12k21V
Linear2FirstOrderSteadyState_kaClQV1V2tau
                        Model Linear2FirstOrderSteadyState_kaClQV1V2tau
Linear2FirstOrderSteadyState_kakk12k21Vtau
                        Model
                        Linear2FirstOrderSteadyState_kakk12k21Vtau
Linear2InfusionSingleDose_ClQV1V2
                        Model Linear2InfusionSingleDose_ClQV1V2
Linear2InfusionSingleDose_kk12k21V
                        Model Linear2InfusionSingleDose_kk12k21V
Linear2InfusionSteadyState_ClQV1V2tau
                        Model Linear2InfusionSteadyState_ClQV1V2tau
Linear2InfusionSteadyState_kk12k21Vtau
                        Model Linear2InfusionSteadyState_kk12k21Vtau
LogNormal               LogNormal
Model                   Model
ModelAnalytic           ModelAnalytic
ModelAnalyticInfusion   ModelAnalyticInfusion
ModelAnalyticInfusionSteadyState
                        ModelAnalyticInfusionSteadyState
ModelAnalyticSteadyState
                        ModelAnalyticSteadyState
ModelError              ModelError
ModelInfusion           ModelInfusion
ModelODE                ModelODE
ModelODEBolus           ModelODEBolus
ModelODEDoseInEquations
                        ModelODEDoseNotInEquations
ModelODEDoseNotInEquations
                        ModelODEDoseNotInEquations
ModelODEInfusion        ModelODEInfusion
ModelODEInfusionDoseInEquation
                        ModelODEInfusionDoseInEquation
ModelParameter          ModelParameter
MultiplicativeAlgorithm
                        MultiplicativeAlgorithm
MultiplicativeAlgorithm_Rcpp
                        Function MultiplicativeAlgorithm_Rcpp
Normal                  Normal
Optimization            Optimization
PFIM-package            Fisher Information matrix for design
                        evaluation/optimization for nonlinear mixed
                        effects models.
PFIMProject             PFIMProject
PGBOAlgorithm           PGBOAlgorithm
PSOAlgorithm            PSOAlgorithm
PopulationFim           PopulationFim
Proportional            Proportional
Report                  Generate optimization report
SamplingTimeConstraints
                        SamplingTimeConstraints
SamplingTimes           SamplingTimes
SimplexAlgorithm        SimplexAlgorithm
adjustGradient          adjustGradient: adjust the gradient for the log
                        normal distribution.
armAdministration       getArmAdministration: get the administration
                        parameters of an arm.
checkSamplingTimeConstraintsForMetaheuristic
                        checkSamplingTimeConstraintsForMetaheuristic
checkValiditySamplingConstraint
                        checkValiditySamplingConstraint: check if the
                        constraints used for the design optimization
                        are valid.
computeVMat             computeVMat
constraintsTableForReport
                        constraintsTableForReport: table of the
                        PGBOAlgorithm constraints for the report.
convertPKModelAnalyticToPKModelODE
                        convertPKModelAnalyticToPKModelODE: conversion
                        from analytic to ode
defineFim               define the type of Fisher information matrix:
                        population, individual or Bayesian
defineModelAdministration
                        defineModelAdministration: define the
                        administration
defineModelEquationsFromLibraryOfModel
                        defineModelEquationsFromLibraryOfModel: define
                        the model equations giving the models in the
                        library of models.
defineModelType         defineModelType: define the class of the model
                        to be evaluated.
defineModelWrapper      defineModelWrapper: define the model wrapper
                        for the ode solver
defineOptimizationAlgorithm
                        Define optimization algorithm
definePKModel           definePKModel: define a PK model from library
                        of model
definePKPDModel         definePKPDModel: define a PKPD model from
                        library of model
evaluateArm             evaluateArm: evaluation of the model with the
                        arm parameters.
evaluateDesign          evaluateDesign: evaluation of a design.
evaluateErrorModelDerivatives
                        evaluateErrorModelDerivatives; evaluate the
                        derivatives of the model error.
evaluateFim             evaluateFim: evaluation of the Fim
evaluateInitialConditions
                        evaluateInitialConditions: evaluate the initial
                        conditions.
evaluateModel           evaluateModel: evaluate the model
evaluateModelGradient   evaluateModelGradient: evaluate the gradient of
                        the model
evaluateModelVariance   evaluateModelVariance: evaluate the variance of
                        the model
evaluateVarianceFIM     evaluateVarianceFIM: evaluate the variance
finiteDifferenceHessian
                        finiteDifferenceHessian: compute the Hessian
fisherSimplex           Compute the fisher.simplex
fun.amoeba              Compute the fun.amoeba
generateDosesCombination
                        generateDosesCombination: generate the
                        combination for the doses.
generateFimsFromConstraints
                        Generate FIMs from constraints
generateReportEvaluation
                        generateReportEvaluation: generate the report
                        for the model evaluation.
generateReportOptimization
                        generateReportOptimization: generate the report
                        for the design optimization.
generateSamplingTimesCombination
                        generateSamplingTimesCombination: generate the
                        combination for the samplings.
generateSamplingsFromSamplingConstraints
                        generateSamplingsFromSamplingConstraints
getArmConstraints       getArmConstraints: get the administration and
                        sampling time constraints for the
                        MultiplicativeAlgorithm.
getArmData              getArmData: extract arm data for The Report
getCorrelationMatrix    getCorrelationMatrix : get the correlation
                        matrix
getDcriterion           getDcriterion : get the Dcriterion
getDeterminant          getDeterminant: get the determinant
getFim                  getFim: get the Fisher matrix.
getFisherMatrix         getFisherMatrix: display the Fisher matrix
                        components
getListLastName         getListLastName: routine to get the names of
                        last element of a nested list.
getModelErrorData       getModelErrorData: get the parameters sigma
                        slope and sigma inter (used for the report).
getModelParametersData
                        getModelParametersData: get model parameters
                        data for report.
getRSE                  getRSE: get the RSE
getSE                   getSE: get the SE
getSamplingData         getSamplingData: extract sampling times and max
                        sampling time used for plot.
getShrinkage            getShrinkage: get the shrinkage
optimizeDesign          Optimization PGBOAlgorithm
plotEvaluation          plotEvaluation: plots for the evaluation of the
                        model responses.
plotEvaluationResults   plotEvaluationResults: process for the
                        evaluation of the responses.
plotEvaluationSI        plotEvaluationSI: process for the evaluation of
                        the gradient of the responses.
plotFrequencies         Plot frequencies for the FedorovWynn algorithm
plotFrequenciesFedorovWynnAlgorithm
                        plotFrequenciesFedorovWynnAlgorithm
plotRSE                 Plot relative standard errors
plotRSEFIM              plotRSEFIM: barplot for the RSE
plotSE                  Plot standard errors
plotSEFIM               plotSEFIM: barplot for the SE
plotSensitivityIndices
                        Plot sensitivity indices.
plotShrinkage           plotShrinkage: plot the shrinkage values.
plotWeights             Plot weights for the multiplicative algorithm
plotWeightsMultiplicativeAlgorithm
                        plotWeightsMultiplicativeAlgorithm: plot the
                        optimal weight.
processArmEvaluationResults
                        processArmEvaluationResults: process for the
                        evaluation of an arm.
processArmEvaluationSI
                        processArmEvaluationSI: process for the
                        evaluation of the gradient of the responses.
replaceVariablesLibraryOfModels
                        replaceVariablesLibraryOfModels: replace
                        variable in the LibraryOfModels
run                     Run optimization
setEvaluationFim        setEvaluationFim: set the Fim results.
setOptimalArms          setOptimalArms: set the optimal arms of an
                        optimization algorithm.
setSamplingConstraintForOptimization
                        setSamplingConstraintForOptimization: set the
                        sampling time constraints for an arm for the
                        design optimization.
show                    Show optimization results
showFIM                 showFIM: show the Fim in the R console.
tablesForReport         tablesForReport: generate the table for the
                        report.
updateSamplingTimes     updateSamplingTimes: update sampling times for
                        plotting used for plot
