CAS.checksum            Test the check digit of a CAS number to confirm
                        validity
EPA.ref                 Reference for EPA Physico-Chemical Data
Tables.Rdata.stamp      A timestamp of table creation
add_chemtable           Add a table of chemical information for use in
                        making httk predictions.
age_draw_smooth         Draws ages from a smoothed distribution for a
                        given gender/race combination
apply_clint_adjustment
                        Correct the measured intrinsive hepatic
                        clearance for fraction free
apply_fup_adjustment    Correct the measured fraction unbound in plasma
                        for lipid binding
armitage_estimate_sarea
                        Estimate well surface area
armitage_eval           Armitage In Vitro Distribution Model
augment.table           Add a parameter value to the
                        chem.physical_and_invitro.data table
available_rblood2plasma
                        Find the best available ratio of the blood to
                        plasma concentration constant.
benchmark_httk          Assess the current performance of httk relative
                        to historical benchmarks
blood_mass_correct      Find average blood masses by age.
blood_weight            Predict blood mass.
bmiage                  CDC BMI-for-age charts
body_surface_area       Predict body surface area.
bone_mass_age           Predict bone mass
brain_mass              Predict brain mass.
calc_analytic_css       Calculate the analytic steady state plasma
                        concentration.
calc_analytic_css_1comp
                        Calculate the analytic steady state
                        concentration for the one compartment model.
calc_analytic_css_3comp
                        Calculate the analytic steady state
                        concentration for model 3compartment
calc_analytic_css_3comp2
                        Calculate the analytic steady state
                        concentration for model 3compartment
calc_analytic_css_3compss
                        Calculate the analytic steady state
                        concentration for the three compartment
                        steady-state model
calc_analytic_css_pbtk
                        Calculate the analytic steady state plasma
                        concentration for model pbtk.
calc_analytic_css_sumclearances
                        Calculate the steady state concentration for
                        the sum of clearances steady-state model with
                        exhalation
calc_clearance_frac     Calculate the fractional contributions to total
                        clearance
calc_css                Find the steady state concentration and the day
                        it is reached.
calc_dermal_equiv       Calculate Dermal Equivalent Dose
calc_dow                Calculate the distribution coefficient
calc_elimination_rate   Calculate the elimination rate for a one
                        compartment model
calc_fbio.oral          Functions for calculating the bioavaialble
                        fractions from oral doses
calc_fetal_phys         Calculate maternal-fetal physiological
                        parameters
calc_fup_correction     Calculate the correction for lipid binding in
                        plasma binding assay
calc_half_life          Calculates the half-life for a one compartment
                        model.
calc_hep_bioavailability
                        Calculate first pass heaptic metabolism
calc_hep_clearance      Calculate the hepatic clearance.
calc_hep_fu             Calculate the free chemical in the hepaitic
                        clearance assay
calc_hepatic_clearance
                        Calculate the hepatic clearance (deprecated).
calc_ionization         Calculate the ionization.
calc_kair               Calculate air:matrix partition coefficients
calc_krbc2pu            Back-calculates the Red Blood Cell to Unbound
                        Plasma Partition Coefficient
calc_ma                 Calculate the membrane affinity
calc_maternal_bw        Calculate maternal body weight
calc_mc_css             Distribution of chemical steady state
                        concentration with uncertainty and variability
calc_mc_oral_equiv      Calculate Monte Carlo Oral Equivalent Dose
calc_mc_tk              Conduct multiple TK simulations using Monte
                        Carlo
calc_rblood2plasma      Calculate the constant ratio of the blood
                        concentration to the plasma concentration.
calc_stats              Calculate toxicokinetic summary statistics
                        (deprecated).
calc_tkstats            Calculate toxicokinetic summary statistics.
calc_total_clearance    Calculate the total plasma clearance.
calc_vdist              Calculate the volume of distribution for a one
                        compartment model.
cas_id_check            CAS number format check function
check_model             Check for sufficient model parameters
chem.invivo.PK.aggregate.data
                        Parameter Estimates from Wambaugh et al. (2018)
chem.invivo.PK.summary.data
                        Summary of published toxicokinetic time course
                        experiments
chem.physical_and_invitro.data
                        Physico-chemical properties and in vitro
                        measurements for toxicokinetics
ckd_epi_eq              CKD-EPI equation for GFR.
convert_solve_x         convert_solve_x
convert_units           convert_units
create_mc_samples       Create a table of parameter values for Monte
                        Carlo
dawson2021              Dawson et al. 2021 data
dawson2023              Machine Learning PFAS Half-Life Predictions
                        from Dawson et al. 2023
dtxsid_id_check         DTXSID number format check function
estimate_gfr            Predict GFR.
estimate_gfr_ped        Predict GFR in children.
estimate_hematocrit     Generate hematocrit values for a virtual
                        population
example.seem            SEEM Example Data We can grab SEEM daily intake
                        rate predictions already in RData format from
                        https://github.com/HumanExposure/SEEM3RPackage/tree/main/SEEM3/data
                        Download the file Ring2018Preds.RData
example.toxcast         ToxCast Example Data The main page for the
                        ToxCast data is here:
                        https://www.epa.gov/comptox-tools/exploring-toxcast-data
                        Most useful to us is a single file containing
                        all the hits across all chemcials and assays:
                        https://clowder.edap-cluster.com/datasets/6364026ee4b04f6bb1409eda?space=62bb560ee4b07abf29f88fef
export_pbtk_jarnac      Export model to jarnac.
export_pbtk_sbml        Export model to sbml.
gen_age_height_weight   Generate demographic parameters for a virtual
                        population
gen_height_weight       Generate heights and weights for a virtual
                        population.
gen_serum_creatinine    Generate serum creatinine values for a virtual
                        population.
get_2023pfasinfo        Retrieve chemical information on 2023 EPA PFAS
                        Chemicals
get_caco2               Retrieve in vitro measured Caco-2 membrane
                        permeabilit
get_chem_id             Retrieve chemical identity from HTTK package
get_cheminfo            Retrieve chemical information available from
                        HTTK package
get_clint               Retrieve and parse intrinsic hepatic clearance
get_fbio                Retrieve or calculate fraction of chemical
                        absorbed from the gut
get_fup                 Retrieve and parse fraction unbound in plasma
get_gfr_category        Categorize kidney function by GFR.
get_input_param_timeseries
                        Get timeseries containing the change of each of
                        the input parameters.
get_invitroPK_param     Retrieve species-specific in vitro data from
                        chem.physical_and_invitro.data table
get_lit_cheminfo        Get literature Chemical Information.
get_lit_css             Get literature Css
get_lit_oral_equiv      Get Literature Oral Equivalent Dose
get_physchem_param      Get physico-chemical parameters from
                        chem.physical_and_invitro.data table
get_rblood2plasma       Get ratio of the blood concentration to the
                        plasma concentration.
get_weight_class        Assign weight class (underweight, normal,
                        overweight, obese)
get_wetmore_cheminfo    Get literature Chemical Information.
                        (deprecated).
get_wetmore_css         Get literature Css (deprecated).
get_wetmore_oral_equiv
                        Get Literature Oral Equivalent Dose
                        (deprecated).
hct_h                   KDE bandwidths for residual variability in
                        hematocrit
hematocrit_infants      Predict hematocrit in infants under 1 year old.
honda.ivive             Return the assumptions used in Honda et al.
                        2019
honda2023.data          Measured Caco-2 Apical-Basal Permeability Data
honda2023.qspr          Predicted Caco-2 Apical-Basal Permeabilities
httk.performance        Historical Performance of R Package httk
httk_chem_subset        HTTK data chemical subsetting function
httk_vignettes          Interact with HTTK vignettes
httkpop                 httkpop: Virtual population generator for HTTK.
httkpop_biotophys_default
                        Convert HTTK-Pop-generated parameters to HTTK
                        physiological parameters
httkpop_direct_resample
                        Generate a virtual population by directly
                        resampling the NHANES data.
httkpop_direct_resample_inner
                        Inner loop function called by
                        'httkpop_direct_resample'.
httkpop_generate        Generate a virtual population for PBTK
httkpop_mc              httk-pop: Correlated human physiological
                        parameter Monte Carlo
httkpop_virtual_indiv   Generate a virtual population by the virtual
                        individuals method.
hw_H                    KDE bandwidth for residual variability in
                        height/weight
in.list                 Convenience Boolean (yes/no) functions to
                        identify chemical membership in several key
                        lists.
invitro.assay.params    ToxCast In Vitro Assay Descriptors
invitro_mc              Monte Carlo for in vitro toxicokinetic
                        parameters including uncertainty and
                        variability.
is.httk                 Convenience Boolean (yes/no) function to
                        identify chemical membership and treatment
                        within the httk project.
is_in_inclusive         Checks whether a value, or all values in a
                        vector, is within inclusive limits
kapraun2019             Kapraun et al. 2019 data
kidney_mass_children    Predict kidney mass for children
kramer_eval             Evaluate the Kramer In Vitro Distribution model
list_models             List all available HTTK models
liver_mass_children     Predict liver mass for children
load_dawson2021         Load CLint and Fup QSPR predictions from Dawson
                        et al. 2021.
load_honda2025          Load Caco2 pereneability QSPR predictions from
                        Honda et al. 2025
load_pradeep2020        Load CLint and Fup QSPR predictions predictions
                        from Pradeep et al. 2020.
load_sipes2017          Load CLint and Fup QSPR predictions from Sipes
                        et al 2017.
lump_tissues            Lump tissue parameters into model compartments
lung_mass_children      Predict lung mass for children
mcnally_dt              Reference tissue masses and flows from tables
                        in McNally et al. (2014)
mecdt                   Pre-processed NHANES data.
monte_carlo             Monte Carlo for toxicokinetic model parameters
pancreas_mass_children
                        Predict pancreas mass for children
parameterize_1comp      Parameters for a one compartment (empirical)
                        toxicokinetic model
parameterize_1tri_pbtk
                        Parameterize_1tri_PBTK
parameterize_3comp      Parameters for a three-compartment
                        toxicokinetic model (dynamic)
parameterize_3comp2     Parameters for a three-compartment
                        toxicokinetic model (dynamic)
parameterize_IVD        Parameterize In Vitro Distribution Models
parameterize_armitage   Parameterize Armitage In Vitro Distribution
                        Model
parameterize_dermal_pbtk
                        Parameterizea generic PBTK model with dermal
                        exposure
parameterize_fetal_pbtk
                        Parameterize_fetal_PBTK
parameterize_gas_pbtk   Parameters for a generic gas inhalation
                        physiologically-based toxicokinetic model
parameterize_kramer     Parameterize Kramer IVD Model
parameterize_pbtk       Parameters for a generic physiologically-based
                        toxicokinetic model
parameterize_pfas1comp
                        Parameters for a one compartment (empirical)
                        toxicokinetic model for PFAS
parameterize_schmitt    Parameters for Schmitt's (2008) Tissue
                        Partition Coefficient Method
parameterize_steadystate
                        Parameters for a three-compartment
                        toxicokinetic model at steady-state
parameterize_sumclearances
                        Parameters for a three-compartment model at
                        steady-state with exhalation
parameterize_sumclearancespfas
                        Parameters for a three-compartment model at
                        steady-state with exhalation and resorption
pearce2017regression    Pearce et al. 2017 data
pfas.clearance          Interspecies In vivo Clearance Data for PFAS
physiology.data         Species-specific physiology parameters
pradeep2020             Pradeep et al. 2020
predict_partitioning_schmitt
                        Predict partition coefficients using the method
                        from Schmitt (2008).
propagate_invitrouv_1comp
                        Propagates uncertainty and variability in in
                        vitro HTTK data into one compartment model
                        parameters
propagate_invitrouv_3comp
                        Propagates uncertainty and variability in in
                        vitro HTTK data into three compartment model
                        parameters
propagate_invitrouv_pbtk
                        Propagates uncertainty and variability in in
                        vitro HTTK data into PBPK model parameters
r_left_censored_norm    Returns draws from a normal distribution with a
                        lower censoring limit of lod (limit of
                        detection)
reset_httk              Reset HTTK to Default Data Tables
rfun                    Randomly draws from a one-dimensional KDE
rmed0non0u95            Draw random numbers with LOD median but
                        non-zero upper 95th percentile
scale_dosing            Scale mg/kg body weight doses according to body
                        weight and units
scr_h                   KDE bandwidths for residual variability in
                        serum creatinine
set_httk_precision      set_httk_precision
sipes2017               Sipes et al. 2017 data
skeletal_muscle_mass    Predict skeletal muscle mass
skeletal_muscle_mass_children
                        Predict skeletal muscle mass for children
skin_mass_bosgra        Predict skin mass
solve_1comp             Solve one compartment TK model
solve_1comp_lifestage   Solve '1comp_lifestage' model, which has
                        time-dependent parameters
solve_1tri_pbtk         Solve_1tri_PBTK
solve_3comp             Solve_3comp
solve_3comp2            Solve_3comp2
solve_3comp_lifestage   Solve the '3comp_lifestage' model, which has
                        time-dependent parameters
solve_dermal_pbtk       Solve_dermal_PBTK
solve_fetal_pbtk        Solve_fetal_PBTK
solve_full_pregnancy    Solve_full_pregnancy
solve_gas_pbtk          solve_gas_pbtk
solve_model             Solve_model
solve_pbtk              Solve_PBTK
solve_pbtk_lifestage    Solve the 'pbtk_lifestage' model, which has
                        time-dependent parameters
spleen_mass_children    Predict spleen mass for children
tissue.data             Tissue composition and species-specific
                        physiology parameters
tissue_masses_flows     Given a data.table describing a virtual
                        population by the NHANES quantities, generates
                        HTTK physiological parameters for each
                        individual.
tissue_scale            Allometric scaling.
well_param              Microtiter Plate Well Descriptions for Armitage
                        et al. (2014) Model
wfl                     WHO weight-for-length charts
