Package: progme
Type: Package
Title: Extended Progression Models for Repeated Measures
Version: 0.1.0
Authors@R: c(
    person("Mukul", "Bijalwan", email = "mukulbijalwan555@gmail.com",
           role = c("aut", "cre"),
           comment = c(ORCID = "0009-0001-3040-6912")),
    person("Gunjan", "Aggrwal", role = "aut"),
    person("Mukul", "Jain", role = "aut"))
Description: Extended progression models for repeated measures in progressive
    disease clinical trials. Provides nonlinear mixed-effects progression
    models (linear, plateau, Emax, exponential decay), delayed treatment
    onset estimation by profile likelihood, joint longitudinal-survival
    models for informative dropout, competing-risks extensions,
    biomarker-informed adaptive dosing rules, and simulation-based power
    and sample-size calculation. The progression-model view of treatment
    effects, in which effects are characterised on the underlying disease
    trajectory rather than as additive shifts on the outcome scale, follows
    Raket (2022) <doi:10.1002/sim.9581>. The nonlinear mixed-effects
    machinery is built on the 'nlme' implementation described by Pinheiro
    and Bates (2000, ISBN 978-0-387-98957-0), and the joint modelling of
    longitudinal and time-to-event data follows Rizopoulos (2012,
    ISBN 978-1-4398-7286-4).
License: GPL (>= 3)
Encoding: UTF-8
LazyData: true
Depends: R (>= 4.1.0)
Imports: nlme, survival, ggplot2, stats, graphics, utils
Suggests: rstan, testthat (>= 3.0.0), knitr, rmarkdown
VignetteBuilder: knitr
Config/testthat/edition: 3
URL: https://github.com/MukulBijalwan/progme
BugReports: https://github.com/MukulBijalwan/progme/issues
Config/roxygen2/version: 8.1.0
NeedsCompilation: no
Packaged: 2026-10-13 13:47:08 UTC; Admin
Author: Mukul Bijalwan [aut, cre] (ORCID:
    <https://orcid.org/0009-0001-3040-6912>),
  Gunjan Aggrwal [aut],
  Mukul Jain [aut]
Maintainer: Mukul Bijalwan <mukulbijalwan555@gmail.com>
Repository: CRAN
Date/Publication: 2026-10-22 10:30:09 UTC
Built: R 4.5.2; ; 2026-10-22 12:21:05 UTC; unix
