Population Fisher Information Matrix

Documentation for package ‘PFIM’ version 8.0

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Population Fisher Information for Design Evaluation and Optimization in NLME Models

-- A --

Additive	Additive
Administration	Administration
AdministrationConstraints	AdministrationConstraints
Arm	Arm

-- B --

BayesianFim

-- C --

CategoricalCovariate	CategoricalCovariate
CategoricalCovariateWithIOV	CategoricalCovariateWithIOV
Combined1	Combined1
Combined2	Combined2
Constant	Constant
Covariate	Covariate
CovariateModelEquation	CovariateModelEquation
CovariateTest	CovariateTest Class
CovariateTest-class	CovariateTest Class

-- D --

Design	Design
Distribution	Distribution

-- E --

Evaluation	Evaluation
Exponential	Exponential

-- F --

FedorovWynnAlgorithm	FedorovWynnAlgorithm
Fim	Fim

-- G --

getCorrelationMatrix	Retrieve correlation matrix from results
getCovariateTestTables	Build HTML tables from a covariate test result
getDcriterion	Retrieve D-criterion from project results
getDeterminant	Retrieve determinant of the Fisher matrix
getEvaluationDesign	Per-design evaluation result from a multi-design 'run()'.
getFisherMatrix	Retrieve the Fisher information matrix from results
getMixtureDcriterion	D-criterion of the continuous mixture over retained Multiplicative cells.
getModelParametersData	Parameter table for reports (mu, omega2, gamma2, fix flags, distribution)
getRealisedDcriterion	D-criterion of the single protocol implemented after Multiplicative allocation.
getRSE	Retrieve relative standard errors from results
getSE	Retrieve standard errors from results
getShrinkage	Retrieve shrinkage metrics from results

-- I --

IndividualFim

-- L --

-- M --

Model	Model
ModelAnalytic	ModelAnalytic
ModelAnalyticInfusion	ModelAnalyticInfusion
ModelAnalyticInfusionSteadyState	ModelAnalyticInfusionSteadyState
ModelAnalyticSteadyState	ModelAnalyticSteadyState
ModelError	ModelError
ModelInfusion	ModelInfusion
ModelODE	ModelODE
ModelODEBolus	ModelODEBolus
ModelODEDoseInEquations	ModelODEDoseInEquations
ModelODEDoseNotInEquations	ModelODEDoseNotInEquations
ModelODEInfusion	ModelODEInfusion
ModelODEInfusionDoseInEquation	ModelODEInfusionDoseInEquation
ModelParameter	ModelParameter
MultiplicativeAlgorithm	MultiplicativeAlgorithm

-- N --

Normal

-- O --

Optimization

-- P --

package-PFIM	Population Fisher Information for Design Evaluation and Optimization in NLME Models
pdModelLibrary	Default built-in PD model library instance.
PFIM	Population Fisher Information for Design Evaluation and Optimization in NLME Models
pfim-constraints-helpers	Constraint tables for optimization reports.
PFIMProject	PFIMProject
pfim_get_option	Read a PFIM session option
pfim_list_extensions	List registered extensions
pfim_registered_fim_types	Registered model class names
pfim_registered_model_classes	Registered model class names
pfim_registered_optimizers	Registered model class names
pfim_register_fim_type	Register a custom FIM type
pfim_register_model_class	Register a model class
pfim_register_optimizer	Register a custom optimizer
pfim_reset_session	Reset PFIM session options and clear all computed-data caches.
pfim_resolve_model_class	Resolve model class name for a project
pfim_set_option	Set PFIM session options
PGBOAlgorithm	PGBOAlgorithm
pkModelLibrary	Default built-in PK model library instance.
plotEvaluation	Plot evaluation outputs for a project
plotFrequencies	Plot optimized sampling frequencies
plotRSE	Plot relative standard errors for project results
plotSE	Plot standard errors for project results
plotSensitivityIndices	Plot sensitivity indices for a project
plotShrinkage	Plot Bayesian shrinkage from a FIM
plotWeights	Plot optimized arm weights
PopulationFim	PopulationFim
projectOf	Nested 'PFIMProject' for an 'Optimization'
projectProp	Read a project field
projectProp<-	Read a project field
prop	Property accessor (S7); project fields on 'Optimization' read slot 'project'.
prop<-	Property accessor (S7); project fields on 'Optimization' read slot 'project'.
Proportional	Proportional
PSOAlgorithm	PSOAlgorithm

-- R --

Report	Generate an HTML evaluation or optimization report
run	Run a PFIM evaluation or optimization project

-- S --

SamplingTimeConstraints	SamplingTimeConstraints
SamplingTimes	SamplingTimes
saveCovariateTest	Save covariate test results to a text file
showFIM	Print FIM summaries to the console
SimplexAlgorithm	SimplexAlgorithm

LibraryOfModels	LibraryOfModels
LibraryOfPDModels	LibraryOfPDModels
LibraryOfPKModels	LibraryOfPKModels
Linear2BolusSingleDose_ClQV1V2	Analytic PK equation: Linear2BolusSingleDose_ClQV1V2.
Linear2BolusSingleDose_kk12k21V	Analytic PK equation: Linear2BolusSingleDose_kk12k21V (micro-constant form).
Linear2BolusSteadyState_ClQV1V2tau	Analytic PK equation: Linear2BolusSteadyState_ClQV1V2tau.
Linear2BolusSteadyState_kk12k21Vtau	Analytic PK equation: Linear2BolusSteadyState_kk12k21Vtau.
Linear2FirstOrderSingleDose_kaClQV1V2	Analytic PK equation: Linear2FirstOrderSingleDose_kaClQV1V2.
Linear2FirstOrderSingleDose_kakk12k21V	Analytic PK equation: Linear2FirstOrderSingleDose_kakk12k21V.
Linear2FirstOrderSteadyState_kaClQV1V2tau	Analytic PK equation: Linear2FirstOrderSteadyState_kaClQV1V2tau.
Linear2FirstOrderSteadyState_kakk12k21Vtau	Analytic PK equation: Linear2FirstOrderSteadyState_kakk12k21Vtau.
Linear2InfusionSingleDose_ClQV1V2	Analytic PK equation: Linear2InfusionSingleDose_ClQV1V2.
Linear2InfusionSingleDose_kk12k21V	Analytic PK equation: Linear2InfusionSingleDose_kk12k21V.
Linear2InfusionSteadyState_ClQV1V2tau	Analytic PK equation: Linear2InfusionSteadyState_ClQV1V2tau.
Linear2InfusionSteadyState_kk12k21Vtau	Analytic PK equation: Linear2InfusionSteadyState_kk12k21Vtau.
LogNormal	LogNormal