adni_simulated          Simulated ADNI-style Alzheimer's trial data
biomarker_dosing_rule   Biomarker-informed adaptive dosing rule
check_convergence       Convergence checks
default_priors          Default priors for Bayesian progression models
delayed_effect          Delayed treatment effect function
emax_biomarker          Emax biomarker model
find_sample_size        Find sample size by simulation
fit_pmrm                Unified estimation wrapper
goodness_of_fit         Goodness-of-fit summary
initialize_subjects     Initialize subjects for an adaptive trial
                        simulation
parametric_bootstrap    Parametric bootstrap for confidence intervals
parkinsons_simulated    Simulated Parkinson's trial data with
                        informative dropout
pkpd_concentration      PK/PD helpers for biomarker dosing
plot.pmrm_delayed       Plot a delayed-effect fit
pmrm_adaptive_trial     Run a biomarker-informed adaptive trial
                        simulation
pmrm_competing          Fit a competing-risks progression model
pmrm_delayed            Fit a progression model with delayed treatment
                        onset
pmrm_joint              Fit a joint longitudinal-survival model
pmrm_nlme               Fit a nonlinear progression mixed-effects model
population_trajectory   Population-level trajectory over a time grid
power_pmrm              Simulation-based power for progression trials
predict.pmrm_nlme       Predict from a fitted progression model
print.pmrm_delayed      Print method for delayed-effect fits
scenario_base           Scenario builders for trial simulation studies
simulate_biomarker      Simulate biomarker measurements under the PK/PD
                        model
simulate_joint_trial    Simulate a trial with informative dropout via a
                        joint model mechanism
simulate_progression_trial
                        Simulate a progression trial
subject_summaries       Extract subject-level summary (EB intercept and
                        slope)
summary.pmrm_competing
                        Summarize a competing-risks fit
summary.pmrm_delayed    Summarize a delayed-effect fit
summary.pmrm_joint      Summarize a joint model fit
to_event_data           Reshape long trial data to per-subject event
                        data
vpc                     Visual predictive check (VPC)
