Design and Analysis for Clinical Trials

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Documentation for package ‘DACT’ version 1.0.0

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A E F G H I M N O P S T

-- A --

asd_ci_est_back Group sequential designs / Adaptive sequential designs: Final analysis, With one sample size change
asd_ci_est_one_arm_2_stage Final analysis: two stage design, with sample size change
asd_ci_est_one_arm_3_stage Final analysis: three stage design, with sample size change
asd_new_design Group sequential designs / Adaptive sequential designs: Interim analysis, Non-survival analysis, Use theta_interim
asd_new_design_survival Group sequential designs / Adaptive sequential designs: Interim analysis, Survival analysis, Use theta_interim
asd_new_design_theta Group sequential designs / Adaptive sequential designs: Interim analysis, Non-survival analysis, Input theta
asd_new_design_theta_survival Group sequential designs / Adaptive sequential designs: Interim analysis, Survival analysis, Input theta
asd_power_simu_binary Group sequential designs / Adaptive sequential designs: Simulations, Binary distribution, Operating characteristics
asd_power_simu_neg_binomial Group sequential designs / Adaptive sequential designs: Simulations, Negative binomial distribution, Operating characteristics
asd_power_simu_normal Group sequential designs / Adaptive sequential designs: Simulations, Normal distribution, Operating characteristics
asd_power_simu_poisson Group sequential designs / Adaptive sequential designs: Simulations, Poisson distribution, Operating characteristics
asd_power_simu_survival Group sequential designs / Adaptive sequential designs: Simulations, Survival analysis, Operating characteristics
asd_simu_OC_binary Group sequential designs / Adaptive sequential designs: Simulations, Binary distribution, Optimizing adaptive sequential design
asd_simu_OC_neg_binomial Group sequential designs / Adaptive sequential designs: Simulations, Negative binomial distribution, Optimizing adaptive sequential design
asd_simu_OC_normal Group sequential designs / Adaptive sequential designs: Simulations, Normal distribution, Optimizing adaptive sequential design
asd_simu_OC_poisson Group sequential designs / Adaptive sequential designs: Simulations, Poisson distribution, Optimizing adaptive sequential design
asd_simu_OC_survival Group sequential designs / Adaptive sequential designs: Simulations, Survival analysis, Optimizing adaptive sequential design

-- E --

EXP_3_stg_sz Three-stage design

-- F --

fixed_rej_nbglm_simu Fixed sample designs: Negative binomial distribution, Simulations
fixed_rej_rate_binary Fixed sample designs: Binary distribution, Simulations
fixed_rej_rate_normal Fixed sample designs: Normal distribution, Simulations
fixed_rej_rate_poisson Fixed sample designs: Poisson distribution, Simulations
fixed_rej_rate_surv_cox Fixed sample designs: Survival analysis, Simulations

-- G --

gsd_ci_est Group sequential designs / Adaptive sequential designs: Final analysis, Without sample size change
gsd_ci_est_2_stage Final analysis: two stage design, no sample size change
gsd_ci_est_3_stage Final analysis: three stage design, no sample size change
gsd_power_simu_binary Group sequential designs / Adaptive sequential designs: Simulations, Binary distribution, Type I error and power
gsd_power_simu_negbinom Group sequential designs / Adaptive sequential designs: Simulations, Negative binomial distribution, Type I error and power
gsd_power_simu_normal Group sequential designs / Adaptive sequential designs: Simulations, Normal distribution, Type I error and power
gsd_power_simu_poisson Group sequential designs / Adaptive sequential designs: Simulations, Poisson distribution, Type I error and power
gsd_power_simu_survival Group sequential designs / Adaptive sequential designs: Simulations, Survival analysis, Type I error and power

-- H --

hybrid_fixed_prior_rej_binary_simu Hybrid: Simulations, Binary distribution, Using given estimates of informative prior
hybrid_fixed_prior_rej_negbinom_simu Hybrid: Simulations, Negative binomial distribution, Using given estimates of informative prior
hybrid_fixed_prior_rej_normal_simu Hybrid: Simulations, Normal distribution, Using given estimates of informative prior
hybrid_fixed_prior_rej_poisson_simu Hybrid: Simulations, Poisson distribution, Using given estimates of informative prior
hybrid_fixed_prior_rej_survival_simu Hybrid: Simulations, Survival analysis, Using given estimates of informative prior
hybrid_random_prior_rej_binary_simu Hybrid: Simulations, Binary distribution, Using random informative prior from previous trial
hybrid_random_prior_rej_negbinom_simu Hybrid: Simulations, Negative binomial distribution, Using random informative prior from previous trial
hybrid_random_prior_rej_normal_simu Hybrid: Simulations, Normal distribution, Using random informative prior from previous trial
hybrid_random_prior_rej_poisson_simu Hybrid: Simulations, Poisson distribution, Using random informative prior from previous trial
hybrid_random_prior_rej_survival_simu Hybrid: Simulations, Survival analysis, Using random informative prior from previous trial
hybrid_sz Two-stage design: the hybrid design

-- I --

interim_analysis The interim analysis can be conducted for both two-stage and three-stage designs

-- M --

masd_est_back_no_drop Multiple comparisons Group sequential design: Final analysis, With one sample size change, orgin_comp==comp2
masd_est_back_with_drop Multiple comparisons Group sequential design: Final analysis, With one sample size change, orgin_comp>comp2
masd_est_ci Multiple comparisons Group sequential design: Final analysis, Without sample size change
masd_new_samsz Multiple comparisons Group sequential design: Interim analysis, Non-survival analysis, Use theta_interim
masd_new_samsz_survival Multiple comparisons Group sequential design: Interim analysis, Survival analysis, Use theta_interim
masd_new_samsz_theta Multiple comparisons Group sequential design: Interim analysis, Non-survival analysis, Input theta
masd_new_samsz_theta_survival Multiple comparisons Group sequential design: Interim analysis, Survival analysis, Input theta
masd_power_simu_adapt_binary Multiple comparisons Group sequential design: Simulations, Binary distribution, Operating characteristics
masd_power_simu_adapt_neg_binomial Multiple comparisons Group sequential design: Simulations, Negative binomial distribution, Operating characteristics
masd_power_simu_adapt_normal Multiple comparisons Group sequential design: Simulations, Normal distribution, Operating characteristics
masd_power_simu_adapt_poisson Multiple comparisons Group sequential design: Simulations, Poisson distribution, Operating characteristics
masd_power_simu_adapt_survival Multiple comparisons Group sequential design: Simulations, Survival analysis, Operating characteristics
masd_simu_OC_binary Multiple comparisons Group sequential design: Simulations, Binary distribution, Optimizing adaptive sequential design
masd_simu_OC_neg_binomial Multiple comparisons Group sequential design: Simulations, Negative binomial distribution, Optimizing adaptive sequential design
masd_simu_OC_normal Multiple comparisons Group sequential design: Simulations, Normal distribution, Optimizing adaptive sequential design
masd_simu_OC_poisson Multiple comparisons Group sequential design: Simulations, Poisson distribution, Optimizing adaptive sequential design
masd_simu_OC_survival Multiple comparisons Group sequential design: Simulations, Survival analysis, Optimizing adaptive sequential design
midpnt_sz Two-stage design: the midpoint design
MSD_power_alsp_boundary_binary_diff Multiple comparisons Group sequential design: Binary distribution, Power calculation, Alpha-spending boundary
MSD_power_alsp_boundary_neg_binomial Multiple comparisons Group sequential design: Negative binomial distribution, Power calculation, Alpha-spending boundary
MSD_power_alsp_boundary_normal Multiple comparisons Group sequential design: Normal distribution, Power calculation, Alpha-spending boundary
MSD_power_alsp_boundary_poisson Multiple comparisons Group sequential design: Poisson distribution, Power calculation, Alpha-spending boundary
MSD_power_alsp_boundary_survival_Schoenfeld Multiple comparisons Group sequential design: Survival analysis, Power calculation, Alpha-spending boundary
MSD_power_OF_boundary_binary_diff Multiple comparisons Group sequential design: Binary distribution, Power calculation, O'Brien-Fleming boundary
MSD_power_OF_boundary_neg_binomial Multiple comparisons Group sequential design: Negative binomial distribution, Power calculation, O'Brien-Fleming boundary
MSD_power_OF_boundary_normal Multiple comparisons Group sequential design: Normal distribution, Power calculation, O'Brien-Fleming boundary
MSD_power_OF_boundary_poisson Multiple comparisons Group sequential design: Poisson distribution, Power calculation, O'Brien-Fleming boundary
MSD_power_OF_boundary_survival_Schoenfeld Multiple comparisons Group sequential design: Survival analysis, Power calculation, O'Brien-Fleming boundary
msd_power_simu_binary Multiple comparisons Group sequential design: Simulations, Binary distribution, Type I error and power
msd_power_simu_neg_binomial Multiple comparisons Group sequential design: Simulations, Negative binomial distribution, Type I error and power
msd_power_simu_normal Multiple comparisons Group sequential design: Simulations, Normal distribution, Type I error and power
msd_power_simu_poisson Multiple comparisons Group sequential design: Simulations, Poisson distribution, Type I error and power
msd_power_simu_survival Multiple comparisons Group sequential design: Simulations, Survival analysis, Type I error and power
MSD_Sample_size_alsp_boundary_binary_diff Multiple comparisons Group sequential design: Binary distribution, Sample size calculation, Alpha-spending boundary
MSD_Sample_size_alsp_boundary_neg_binomial Multiple comparisons Group sequential design: Negative binomial distribution, Sample size calculation, Alpha-spending boundary
MSD_Sample_size_alsp_boundary_normal Multiple comparisons Group sequential design: Normal distribution, Sample size calculation, Alpha-spending boundary
MSD_Sample_size_alsp_boundary_poisson Multiple comparisons Group sequential design: Poisson distribution, Sample size calculation, Alpha-spending boundary
MSD_Sample_size_alsp_boundary_survival_Schoenfeld Multiple comparisons Group sequential design: Survival analysis, Sample size calculation, Alpha-spending boundary
MSD_Sample_size_OF_boundary_binary_diff Multiple comparisons Group sequential design: Binary distribution, Sample size calculation, O'Brien-Fleming boundary
MSD_Sample_size_OF_boundary_neg_binomial Multiple comparisons Group sequential design: Negative binomial distribution, Sample size calculation, O'Brien-Fleming boundary
MSD_Sample_size_OF_boundary_normal Multiple comparisons Group sequential design: Normal distribution, Sample size calculation, O'Brien-Fleming boundary
MSD_Sample_size_OF_boundary_poisson Multiple comparisons Group sequential design: Poisson distribution, Sample size calculation, O'Brien-Fleming boundary
MSD_Sample_size_OF_boundary_survival_Schoenfeld Multiple comparisons Group sequential design: Survival analysis, Sample size calculation, O'Brien-Fleming boundary

-- N --

new_sample_size_hybrid Hybrid: New sample size estimation

-- O --

one_arm_ad_3_stg_binary Simulations: adaptive three stage design
one_arm_ad_two_stg_binary Simulations: adaptive two stage design
one_arm_rej_2_stg_binary Simulations: Two stage fixed expanded Simon's design: either hybrid or mid-point design
one_arm_rej_3_stg_binary Simulations: Expanded Simon's design: the three stage design, no sample size change
one_arm_rej_simon_binary Simulations: two stage fixed Simon's design

-- P --

power_alsp_boundary_binary_diff Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Power calculation, Alpha-spending boundary
power_alsp_boundary_binary_diff_NI Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Power calculation, Alpha-spending boundary
power_alsp_boundary_neg_binomial Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Power calculation, Alpha-spending boundary
power_alsp_boundary_neg_binomial_NI Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Power calculation, Alpha-spending boundary
power_alsp_boundary_normal Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Power calculation, Alpha-spending boundary
power_alsp_boundary_normal_NI Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Power calculation, Alpha-spending boundary
power_alsp_boundary_poisson Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Power calculation, Alpha-spending boundary
power_alsp_boundary_poisson_NI Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Power calculation, Alpha-spending boundary
power_alsp_boundary_survival_Schoenfeld Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Power calculation, Alpha-spending boundary
power_alsp_boundary_survival_Schoenfeld_NI Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Power calculation, Alpha-spending boundary
power_binary_diff Fixed sample designs: Binary distribution, Superiority trial, Power calculation
power_binary_diff_NI Fixed sample designs: Binary distribution, Non-inferiority trial, Power calculation
power_OF_boundary_binary_diff Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Power calculation, O'Brien-Fleming boundary
power_OF_boundary_binary_diff_NI Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Power calculation, O'Brien-Fleming boundary
power_OF_boundary_neg_binomial Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Power calculation, O'Brien-Fleming boundary
power_OF_boundary_neg_binomial_NI Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Power calculation, O'Brien-Fleming boundary
power_OF_boundary_normal Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Power calculation, O'Brien-Fleming boundary
power_OF_boundary_normal_NI Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Power calculation, O'Brien-Fleming boundary
power_OF_boundary_poisson Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Power calculation, O'Brien-Fleming boundary
power_OF_boundary_poisson_NI Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Power calculation, O'Brien-Fleming boundary
power_OF_boundary_survival_Schoenfeld Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Power calculation, O'Brien-Fleming boundary
power_OF_boundary_survival_Schoenfeld_NI Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Power calculation, O'Brien-Fleming boundary
power_pocock_boundary_binary_diff Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Power calculation, Pocock boundary
power_pocock_boundary_binary_diff_NI Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Power calculation, Pocock boundary
power_pocock_boundary_neg_binomial Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Power calculation, Pocock boundary
power_pocock_boundary_neg_binomial_NI Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Power calculation, Pocock boundary
power_pocock_boundary_normal Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Power calculation, Pocock boundary
power_pocock_boundary_normal_NI Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Power calculation, Pocock boundary
power_pocock_boundary_poisson Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Power calculation, Pocock boundary
power_pocock_boundary_poisson_NI Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Power calculation, Pocock boundary
power_pocock_boundary_survival_Schoenfeld Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Power calculation, Pocock boundary
power_pocock_boundary_survival_Schoenfeld_NI Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Power calculation, Pocock boundary
power_two_sample_neg_binomial Fixed sample designs: Negative binomial distribution, Superiority trial, Power calculation
power_two_sample_neg_binomial_NI Fixed sample designs: Negative binomial distribution, Non-inferiority trial, Power calculation
power_two_sample_normal Fixed sample designs: Normal distribution, Superiority trial, Power calculation
power_two_sample_normal_NI Fixed sample designs: Normal distribution, Non-inferiority trial, Power calculation
power_two_sample_Poisson Fixed sample designs: Poisson distribution, Superiority trial, Power calculation
power_two_sample_Poisson_NI Fixed sample designs: Poisson distribution, Non-inferiority trial, Power calculation
power_two_sample_surv_Schoenfeld Fixed sample designs: Survival analysis, Superiority trial, Power calculation
power_two_sample_surv_Schoenfeld_NI Fixed sample designs: Survival analysis, Non-inferiority trial, Power calculation

-- S --

Sample_size_alsp_boundary_binary_diff Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Sample size calculation, Alpha-spending boundary
Sample_size_alsp_boundary_binary_diff_NI Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Sample size calculation, Alpha-spending boundary
Sample_size_alsp_boundary_neg_binomial Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Sample size calculation, Alpha-spending boundary
Sample_size_alsp_boundary_neg_binomial_NI Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Sample size calculation, Alpha-spending boundary
Sample_size_alsp_boundary_normal Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Sample size calculation, Alpha-spending boundary
Sample_size_alsp_boundary_normal_NI Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Sample size calculation, Alpha-spending boundary
Sample_size_alsp_boundary_poisson Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Sample size calculation, Alpha-spending boundary
Sample_size_alsp_boundary_poisson_NI Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Sample size calculation, Alpha-spending boundary
Sample_size_alsp_boundary_survival_Schoenfeld Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Sample size calculation, Alpha-spending boundary
Sample_size_alsp_boundary_survival_Schoenfeld_NI Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Sample size calculation, Alpha-spending boundary
sample_size_binary_diff Fixed sample designs: Binary distribution, Superiority trial, Sample size calculation
sample_size_binary_diff_NI Fixed sample designs: Binary distribution, Non-inferiority trial, Sample size calculation
sample_size_neg_binomial Fixed sample designs: Negative binomial distribution, Superiority trial, Sample size calculation
sample_size_neg_binomial_NI Fixed sample designs: Negative binomial distribution, Non-inferiority trial, Sample size calculation
Sample_size_OF_boundary_binary_diff Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Sample size calculation, O'Brien-Fleming boundary
Sample_size_OF_boundary_binary_diff_NI Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundary
Sample_size_OF_boundary_neg_binomial Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Sample size calculation, O'Brien-Fleming boundary
Sample_size_OF_boundary_neg_binomial_NI Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundary
Sample_size_OF_boundary_normal Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Sample size calculation, O'Brien-Fleming boundary
Sample_size_OF_boundary_normal_NI Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundary
Sample_size_OF_boundary_poisson Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Sample size calculation, O'Brien-Fleming boundary
Sample_size_OF_boundary_poisson_NI Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundary
Sample_size_OF_boundary_survival_Schoenfeld Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Sample size calculation, O'Brien-Fleming boundary
Sample_size_OF_boundary_survival_Schoenfeld_NI Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Sample size calculation, O'Brien-Fleming boundary
Sample_size_pocock_boundary_binary_diff Group sequential designs / Adaptive sequential designs: Binary distribution, Superiority trial, Sample size calculation, Pocock boundary
Sample_size_pocock_boundary_binary_diff_NI Group sequential designs / Adaptive sequential designs: Binary distribution, Non-inferiority trial, Sample size calculation, Pocock boundary
Sample_size_pocock_boundary_neg_binomial Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Superiority trial, Sample size calculation, Pocock boundary
Sample_size_pocock_boundary_neg_binomial_NI Group sequential designs / Adaptive sequential designs: Negative binomial distribution, Non-inferiority trial, Sample size calculation, Pocock boundary
Sample_size_pocock_boundary_normal Group sequential designs / Adaptive sequential designs: Normal distribution, Superiority trial, Sample size calculation, Pocock boundary
Sample_size_pocock_boundary_normal_NI Group sequential designs / Adaptive sequential designs: Normal distribution, Non-inferiority trial, Sample size calculation, Pocock boundary
Sample_size_pocock_boundary_poisson Group sequential designs / Adaptive sequential designs: Poisson distribution, Superiority trial, Sample size calculation, Pocock boundary
Sample_size_pocock_boundary_poisson_NI Group sequential designs / Adaptive sequential designs: Poisson distribution, Non-inferiority trial, Sample size calculation, Pocock boundary
Sample_size_pocock_boundary_survival_Schoenfeld Group sequential designs / Adaptive sequential designs: Survival analysis, Superiority trial, Sample size calculation, Pocock boundary
Sample_size_pocock_boundary_survival_Schoenfeld_NI Group sequential designs / Adaptive sequential designs: Survival analysis, Non-inferiority trial, Sample size calculation, Pocock boundary
sample_size_two_sample_normal Fixed sample designs: Normal distribution, Superiority trial, Sample size calculation
sample_size_two_sample_normal_NI Fixed sample designs: Normal distribution, Non-inferiority trial, Sample size calculation
sample_size_two_sample_Poisson Fixed sample designs: Poisson distribution, Superiority trial, Sample size calculation
sample_size_two_sample_Poisson_NI Fixed sample designs: Poisson distribution, Non-inferiority trial, Sample size calculation
sample_size_two_sample_surv_Schoenfeld Fixed sample designs: Survival analysis, Superiority trial, Sample size calculation
sample_size_two_sample_surv_Schoenfeld_NI Fixed sample designs: Survival analysis, Non-inferiority trial, Sample size calculation
simon_ph2_sz Two-stage design: Simon's design

-- T --

Two_stage_asd_simu_OC_binary Phase 2/3 seamless combination Group sequential design: Simulations, Binary distribution, Optimizing adaptive sequential design
Two_stage_asd_simu_OC_neg_binomial Phase 2/3 seamless combination Group sequential design: Simulations, Negative binomial distribution, Optimizing adaptive sequential design
Two_stage_asd_simu_OC_normal Phase 2/3 seamless combination Group sequential design: Simulations, Normal distribution, Optimizing adaptive sequential design
Two_stage_asd_simu_OC_poisson Phase 2/3 seamless combination Group sequential design: Simulations, Poisson distribution, Optimizing adaptive sequential design
Two_stage_asd_simu_OC_survival Phase 2/3 seamless combination Group sequential design: Simulations, Survival analysis, Optimizing adaptive sequential design
two_stage_ci_0 Phase 2/3 seamless combination Group sequential design: Final analysis, Without sample size change, last_vt == 1
two_stage_ci_1 Phase 2/3 seamless combination Group sequential design: Final analysis, Without sample size change, last_vt > 1
two_stage_est_back Phase 2/3 seamless combination Group sequential design: Final analysis, With one sample size change
two_stage_power_alsp_boundary_binary_diff Phase 2/3 seamless combination Group sequential design: Binary distribution, Power calculation, Alpha-spending boundary
two_stage_power_alsp_boundary_neg_binomial Phase 2/3 seamless combination Group sequential design: Negative binomial distribution, Power calculation, Alpha-spending boundary
two_stage_power_alsp_boundary_normal Phase 2/3 seamless combination Group sequential design: Normal distribution, Power calculation, Alpha-spending boundary
two_stage_power_alsp_boundary_poisson Phase 2/3 seamless combination Group sequential design: Poisson distribution, Power calculation, Alpha-spending boundary
two_stage_power_alsp_boundary_survival_Schoenfeld Phase 2/3 seamless combination Group sequential design: Survival analysis, Power calculation, Alpha-spending boundary
two_stage_power_OF_boundary_binary_diff Phase 2/3 seamless combination Group sequential design: Binary distribution, Power calculation, O'Brien-Fleming boundary
two_stage_power_OF_boundary_neg_binomial Phase 2/3 seamless combination Group sequential design: Negative binomial distribution, Power calculation, O'Brien-Fleming boundary
two_stage_power_OF_boundary_normal Phase 2/3 seamless combination Group sequential design: Normal distribution, Power calculation, O'Brien-Fleming boundary
two_stage_power_OF_boundary_poisson Phase 2/3 seamless combination Group sequential design: Poisson distribution, Power calculation, O'Brien-Fleming boundary
two_stage_power_OF_boundary_survival_Schoenfeld Phase 2/3 seamless combination Group sequential design: Survival analysis, Power calculation, O'Brien-Fleming boundary
two_stage_Sample_size_alsp_boundary_binary_diff Phase 2/3 seamless combination Group sequential design: Binary distribution, Sample size calculation, Alpha-spending boundary
two_stage_Sample_size_alsp_boundary_neg_binomial Phase 2/3 seamless combination Group sequential design: Negative binomial distribution, Sample size calculation, Alpha-spending boundary
two_stage_Sample_size_alsp_boundary_normal Phase 2/3 seamless combination Group sequential design: Normal distribution, Sample size calculation, Alpha-spending boundary
two_stage_Sample_size_alsp_boundary_poisson Phase 2/3 seamless combination Group sequential design: Poisson distribution, Sample size calculation, Alpha-spending boundary
two_stage_Sample_size_alsp_boundary_survival_Schoenfeld Phase 2/3 seamless combination Group sequential design: Survival analysis, Sample size calculation, Alpha-spending boundary
two_stage_Sample_size_OF_boundary_binary_diff Phase 2/3 seamless combination Group sequential design: Binary distribution, Sample size calculation, O'Brien-Fleming boundary
two_stage_Sample_size_OF_boundary_neg_binomial Phase 2/3 seamless combination Group sequential design: Negative binomial distribution, Sample size calculation, O'Brien-Fleming boundary
two_stage_Sample_size_OF_boundary_normal Phase 2/3 seamless combination Group sequential design: Normal distribution, Sample size calculation, O'Brien-Fleming boundary
two_stage_Sample_size_OF_boundary_poisson Phase 2/3 seamless combination Group sequential design: Poisson distribution, Sample size calculation, O'Brien-Fleming boundary
two_stage_Sample_size_OF_boundary_survival_Schoenfeld Phase 2/3 seamless combination Group sequential design: Survival analysis, Sample size calculation, O'Brien-Fleming boundary
two_stg_adapt_power_simu_binary Phase 2/3 seamless combination Group sequential design: Simulations, Binary distribution, Operating characteristics
two_stg_adapt_power_simu_neg_binomial Phase 2/3 seamless combination Group sequential design: Simulations, Negative binomial distribution, Operating characteristics
two_stg_adapt_power_simu_normal Phase 2/3 seamless combination Group sequential design: Simulations, Normal distribution, Operating characteristics
two_stg_adapt_power_simu_poisson Phase 2/3 seamless combination Group sequential design: Simulations, Poisson distribution, Operating characteristics
two_stg_adapt_power_simu_survival Phase 2/3 seamless combination Group sequential design: Simulations, Survival analysis, Operating characteristics
two_stg_power_simu_binary Phase 2/3 seamless combination Group sequential design: Simulations, Binary distribution, Type I error and power
two_stg_power_simu_neg_binomial Phase 2/3 seamless combination Group sequential design: Simulations, Negative binomial distribution, Type I error and power
two_stg_power_simu_normal Phase 2/3 seamless combination Group sequential design: Simulations, Normal distribution, Type I error and power
two_stg_power_simu_poisson Phase 2/3 seamless combination Group sequential design: Simulations, Poisson distribution, Type I error and power
two_stg_power_simu_survival Phase 2/3 seamless combination Group sequential design: Simulations, Survival analysis, Type I error and power