Contains the Multi-Species Acute Toxicity Database (CAS & SMILES
    columns only) [United States (US) Department of Health and Human Services
    (DHHS) National Institutes of Health (NIH) National Cancer Institute (NCI),
    "Multi-Species Acute Toxicity Database",
    <https://cactus.nci.nih.gov/download/acute-toxicity-db/>] combined with the
    Toxic Substances Control Act (TSCA) Inventory [United States Environmental
    Protection Agency (US EPA), "Toxic Substances Control Act (TSCA) Chemical
    Substance Inventory",
    <https://www.epa.gov/tsca-inventory/how-access-tsca-inventory} and
    <https://cdxapps.epa.gov/oms-substance-registry-services/substance-list-details/169>]
    and the Agency for Toxic Substances and Disease Registry (ATSDR) Database
    [United States (US) Department of Health and Human Services (DHHS) Centers
    for Disease Control and Prevention (CDC)/Agency for Toxic Substances and
    Disease Registry (ATSDR), "Agency for Toxic Substances and Disease Registry
    (ATSDR) Database",
    <https://cdxapps.epa.gov/oms-substance-registry-services/substance-list-details/105>]
    in 2 data sets. One data set has a focus on the latter 2 databases and one
    data set focuses on the former database. Also contains the collection of
    chemical data from Wikipedia compiled in the US EPA CompTox Chemicals
    Dashboard [United States Environmental Protection Agency (US EPA) /
    Wikimedia Foundation, Inc. "CompTox Chemicals Dashboard v2.2.1",
    <https://comptox.epa.gov/dashboard/chemical-lists/WIKIPEDIA>].

Combines taxonomic classifications of high-throughput 16S rRNA
  gene sequences with reference proteomes of archaeal and bacterial taxa to
  generate amino acid compositions of community reference proteomes. Calculates
  chemical metrics including carbon oxidation state ('Zc'), stoichiometric
  oxidation and hydration state ('nO2' and 'nH2O'), H/C, N/C, O/C, and S/C
  ratios, grand average of hydropathicity ('GRAVY'), isoelectric point ('pI'),
  protein length, and average molecular weight of amino acid residues. Uses
  precomputed reference proteomes for archaea and bacteria derived from the
  Genome Taxonomy Database ('GTDB'). Also includes reference proteomes derived
  from the NCBI Reference Sequence ('RefSeq') database and manual mapping from
  the 'RDP Classifier' training set to 'RefSeq' taxonomy as described by Dick and
  Tan (2023) <doi:10.1007/s00248-022-01988-9>. Processes taxonomic
  classifications in 'RDP Classifier' format or OTU tables in 'phyloseq-class'
  objects from the Bioconductor package 'phyloseq'.