The Statistical Learning Theory (SLT) provides the theoretical background to ensure that a supervised algorithm generalizes the mapping f:X -> Y given f is selected from its search space bias F. This formal result depends on the Shattering coefficient function N(F,2n) to upper bound the empirical risk minimization principle, from which one can estimate the necessary training sample size to ensure the probabilistic learning convergence and, most importantly, the characterization of the capacity of F, including its under and overfitting abilities while addressing specific target problems. In this context, we propose a new approach to estimate the maximal number of hyperplanes required to shatter a given sample, i.e., to separate every pair of points from one another, based on the recent contributions by Har-Peled and Jones in the dataset partitioning scenario, and use such foundation to analytically compute the Shattering coefficient function for both binary and multi-class problems. As main contributions, one can use our approach to study the complexity of the search space bias F, estimate training sample sizes, and parametrize the number of hyperplanes a learning algorithm needs to address some supervised task, what is specially appealing to deep neural networks. Reference: de Mello, R.F. (2019) "On the Shattering Coefficient of Supervised Learning Algorithms" <arXiv:1911.05461>; de Mello, R.F., Ponti, M.A. (2018, ISBN: 978-3319949888) "Machine Learning: A Practical Approach on the Statistical Learning Theory".

Provides a computational framework for analyzing mutations in
    immunoglobulin (Ig) sequences. Includes methods for Bayesian estimation of
    antigen-driven selection pressure, mutational load quantification, building of
    somatic hypermutation (SHM) models, and model-dependent distance calculations.
    Also includes empirically derived models of SHM for both mice and humans.
    Citations: 
    Gupta and Vander Heiden, et al (2015) <doi:10.1093/bioinformatics/btv359>, 
    Yaari, et al (2012) <doi:10.1093/nar/gks457>, 
    Yaari, et al (2013) <doi:10.3389/fimmu.2013.00358>, 
    Cui, et al (2016) <doi:10.4049/jimmunol.1502263>.