Phase I/II adaptive dose-finding design for combination
   studies where toxicity rates are supposed to increase with both agents.

Compares two dataframes with a common key
            and returns the delta records. The package will return
            three dataframes that contain the added, changed,
            and deleted records.

Provides functions to run the CRM and
        TITE-CRM in phase I trials and calibration tools for trial
        planning purposes.

Get Drug information from given differential expression profile. The package search for the bioactive compounds from reference databases such as LINCS containing the genome-wide gene expression signature (GES) from tens of thousands of drug and genetic perturbations (Subramanian et al. (2017) <DOI:10.1016/j.cell.2017.10.049>).

Implementation of automatically computing derivatives
    of functions (see Mailund Thomas (2017) <doi:10.1007/978-1-4842-2881-4>). Moreover, calculating gradients, Hessian and Jacobian matrices is possible.

Preferred methods for common analytical tasks that are
    undertaken across the Department, including number formatting, project
    templates and curated reference data.

Implements an algorithm to effortlessly split a column in an R data frame filled with multiple values separated by delimiters. This automates the process of creating separate columns for each unique value, transforming them into binary outcomes.

Provides extended data frames, with a special data frame column which contains two indexes, with potentially a nesting structure.

A set of functions to perform Raju, van der Linden and Fleer's
    (1995, <doi:10.1177/014662169501900405>) Differential Functioning of Items
    and Tests (DFIT) analyses. It includes functions to use the Monte Carlo Item
    Parameter Replication approach (Oshima, Raju, & Nanda, 2006, <doi:10.1111/j.1745-3984.2006.00001.x>)
    for obtaining the associated statistical significance
    tests cut-off points. They may also be used for a priori and post-hoc power
    calculations (Cervantes, 2017, <doi:10.18637/jss.v076.i05>).