Computes the D', Wn, and conditional asymmetric linkage disequilibrium (ALD) measures for pairs of genetic loci. Performs these linkage disequilibrium (LD) calculations on phased genotype data recorded using Genotype List (GL) String or columnar formats. Alternatively, generates expectation-maximization (EM) estimated haplotypes from phased data, or performs LD calculations on EM estimated haplotypes. Performs sign tests comparing LD values for phased and unphased datasets, and generates heat-maps for each LD measure. Described by Osoegawa et al. (2019a) <doi:10.1016/j.humimm.2019.01.010>, and Osoegawa et. al. (2019b) <doi:10.1016/j.humimm.2019.05.018>.

The Phylogenetic Ornstein-Uhlenbeck Mixed Model (POUMM) allows to 
    estimate the phylogenetic heritability of continuous traits, to test 
    hypotheses of neutral evolution versus stabilizing selection, to quantify 
    the strength of stabilizing selection, to estimate measurement error and to
    make predictions about the evolution of a phenotype and phenotypic variation 
    in a population. The package implements combined maximum likelihood and 
    Bayesian inference of the univariate Phylogenetic Ornstein-Uhlenbeck Mixed 
    Model, fast parallel likelihood calculation, maximum likelihood 
    inference of the genotypic values at the tips, functions for summarizing and
    plotting traces and posterior samples, functions for simulation of a univariate 
    continuous trait evolution model along a phylogenetic tree. So far, the 
    package has been used for estimating the heritability of quantitative traits
    in macroevolutionary and epidemiological studies, see e.g. 
    Bertels et al. (2017) <doi:10.1093/molbev/msx246> and 
    Mitov and Stadler (2018) <doi:10.1093/molbev/msx328>. The algorithm for 
    parallel POUMM likelihood calculation has been published in 
    Mitov and Stadler (2019) <doi:10.1111/2041-210X.13136>.

An implementation of the Partition Of variation (POV) method as
    developed by Dr. Thomas A Little <https://thomasalittleconsulting.com> in
    1993 for the analysis of semiconductor data for hard drive manufacturing.
    POV is based on sequential sum of squares and is an exact method that
    explains all observed variation. It quantitates both the between and within
    factor variation effects and can quantitate the influence of both continuous
    and categorical factors.