When using pooled p-values to adjust for multiple testing, there is an inherent balance that must be struck between rejection based on weak evidence spread among many tests and strong evidence in a few, explored in Salahub and Olford (2023) <arXiv:2310.16600>. This package provides functionality to compute marginal and central rejection levels and the centrality quotient for p-value pooling functions and provides implementations of the chi-squared quantile pooled p-value (described in Salahub and Oldford (2023)) and a proposal from Heard and Rubin-Delanchy (2018) <doi:10.1093/biomet/asx076> to control the quotient's value.

Pool dilution is a isotope tracer technique wherein a 
    biogeochemical pool is artifically enriched with its heavy isotopologue 
    and the gross productive and consumptive fluxes of that pool are 
    quantified by the change in pool size and isotopic composition over time. 
    This package calculates gross production and consumption rates from
    closed-system isotopic pool dilution time series data. Pool size 
    concentrations and heavy isotope (e.g., 15N) content are measured over time 
    and the model optimizes production rate (P) and the first order rate 
    constant (k) by minimizing error in the model-predicted total pool size, 
    as well as the isotopic signature. The model optimizes rates by weighting 
    information against the signal:noise ratio of concentration and heavy-
    isotope signatures using measurement precision as well as the magnitude of 
    change over time. The calculations used here are based on von Fischer and 
    Hedin (2002) <doi:10.1029/2001GB001448> with some modifications.

The 2017 American College of Cardiology and American Heart
  Association blood pressure guideline recommends using 10-year predicted 
  atherosclerotic cardiovascular disease risk to guide the decision to 
  initiate or intensify antihypertensive medication. The guideline recommends 
  using the Pooled Cohort risk prediction equations to predict 10-year 
  atherosclerotic cardiovascular disease risk. This package implements the 
  original Pooled Cohort risk prediction equations and also incorporates 
  updated versions based on more contemporary data and statistical methods.