Methods (standard and advanced) for analysis of agreement between measurement methods. These cover Bland-Altman plots, Deming regression, Lin's Total deviation index, and difference-on-average regression. See Carstensen B. (2010) "Comparing Clinical Measurement Methods: A Practical Guide (Statistics in Practice)" <doi:10.1002/9780470683019> for more information.

Identify and rank CpG DNA methylation conservation along the human 
    genome. Specifically it includes bootstrapping methods to provide ranking 
    which should adjust for the differences in length as without it short 
    regions tend to get higher conservation scores.

DNA methylation is an epigenetic modification involved in genomic stability,
      gene regulation, development and disease.
      DNA methylation occurs mainly through the addition of a methyl group to cytosines, 
      for example to cytosines in a CpG dinucleotide context (CpG stands for a cytosine followed by a guanine).
      Tissue-specific methylation patterns lead to genomic regions with different characteristic
      methylation levels.
      E.g. in vertebrates CpG islands (regions with high CpG content) that are associated to promoter regions of
      expressed genes tend to be unmethylated.
      'MethEvolSIM' is a model-based simulation software for the generation and modification
      of cytosine methylation patterns along a given tree, which can be a genealogy of
      cells within an organism, a coalescent tree of DNA sequences sampled from a population, or a species tree.
      The simulations are based on an extension of the model of
      Grosser & Metzler (2020) <doi:10.1186/s12859-020-3438-5> and allows for changes of
      the methylation states at single cytosine positions as well as simultaneous changes of methylation
      frequencies in genomic structures like CpG islands.

Evaluate bias and precision in method comparison 
    studies. One provides measurements for each method and it takes care of 
    the estimates. Multiple plots to evaluate bias, precision and compare
    methods.