idd35                package:gmvalid                R Documentation

_T_y_p_e _1 _D_i_a_b_e_t_e_s _s_u_s_c_e_p_t_i_b_i_l_i_t_y _l_o_c_i _I_d_d_3 _a_n_d _I_d_d_5

_D_e_s_c_r_i_p_t_i_o_n:

     Loci Idd3 and Idd5 are suspectable to be associated with type 1
     diabetes. This data reflects an animal experiment from Hill et al.
     (2000).

_U_s_a_g_e:

     data(idd35)

_F_o_r_m_a_t:

     A data frame with 313 observations on the following 3 variables.

     '_i_d_d_3' a factor with levels 'NN' and 'BB'

     '_i_d_d_5' a factor with levels 'NN' and 'BB'

     '_g_r_o_u_p' a factor with levels 'controls' 'cases'

_D_e_t_a_i_l_s:

     Data was used from Cordell et al. (2001) to model the joint effect
     of alleles at the loci Idd3 and Idd5 on the outcome "type 1
     diabetes". Only homozygeous genotypes  were available.

_S_o_u_r_c_e:

     Hill NJ, Lyons PA, Armitage N, Todd JA, Wicker LS and Peterson LB
     (2000) _NOD Idd5 locus controls insulitis and diabetes and
     overlaps the  orthologous CTLA4/IDDM12 and NRAMP1 loci in humans._
     Diabetes, 49:1744-1747.

_R_e_f_e_r_e_n_c_e_s:

     Cordell HJ, Todd JA, Hill NJ, Lord CJ, Lyons PA, Peterson LB,
     Wicker LS and Clayton DG (2001) _Statistical modeling of
     interlocus interactions in a complex disease: Rejection of the
     multiplicative model of epistasis in type 1 diabetes._ Genetics,
     158:357-367.

_E_x_a_m_p_l_e_s:

       data(idd35)
       table(idd35)

