Chr	Start	End	Ref	Alt	Gene_system	Gene_region	Gene_symbol	Effect	Mutation_type	AA_change	Cytoband	SIFT_score	SIFT_pred	Polyphen2_HDIV_score	Polyphen2_HDIV_pred	Polyphen2_HVAR_score	Polyphen2_HVAR_pred	LRT_score	LRT_pred	MutationTaster_score	MutationTaster_pred	MutationAssessor_score	MutationAssessor_pred	FATHMM_score	FATHMM_pred	PROVEAN_score	PROVEAN_pred	VEST3_score	VEST3_pred	MetaSVM_score	MetaSVM_pred	MetaLR_score	MetaLR_pred	M-CAP_score	M-CAP_pred	CADD_raw	CADD_score	CADD_phred	DANN_score	DANN_pred	fathmm-MKL_score	fathmm-MKL_pred	Eigen_score	Eigen_pred	GenoCanyon_score	GenoCanyon_pred	fitCons_score	itCons_pred	integrated_confidence_value	GERP++_score	GERP++_pred	phyloP100way_vertebrate	phyloP100way_vertebrate_pred	phyloP20way_mammalian	phastCons100way_vertebrate	phastCons100way_vertebrate_pred	phastCons20way_mammalian	SiPhy_29way_logOdds	SiPhy_29way_logOdds_pred	Interpro_domain	gnomAD_exome_ALL	gnomAD_exome_AFR	gnomAD_exome_AMR	gnomAD_exome_ASJ	gnomAD_exome_EAS	gnomAD_exome_FIN	gnomAD_exome_NFE	gnomAD_exome_OTH	gnomAD_exome_SAS	gnomAD_genome_ALL	gnomAD_genome_AFR	gnomAD_genome_AMR	gnomAD_genome_ASJ	gnomAD_genome_EAS	gnomAD_genome_FIN	gnomAD_genome_NFE	gnomAD_genome_OTH	REVEL	REVEL_pred	InterVar_automated	dbSNP147	ExAC_ALL	ExAC_AFR	ExAC_AMR	ExAC_EAS	ExAC_FIN	ExAC_NFE	ExAC_OTH	ExAC_SAS	ExAC_nontcga_ALL	ExAC_nontcga_AFR	ExAC_nontcga_AMR	ExAC_nontcga_EAS	ExAC_nontcga_FIN	ExAC_nontcga_NFE	ExAC_nontcga_OTH	ExAC_nontcga_SAS	ExAC_nonpsych_ALL	ExAC_nonpsych_AFR	ExAC_nonpsych_AMR	ExAC_nonpsych_EAS	ExAC_nonpsych_FIN	ExAC_nonpsych_NFE	ExAC_nonpsych_OTH	ExAC_nonpsych_SAS	Kaviar_AF	Kaviar_AC	Kaviar_AN	HRC_AF	HRC_AC	HRC_AN	HRC_non1000G_AF	HRC_non1000G_AC	HRC_non1000G_AN	1000g2015aug_all	1000g2015aug_afr	1000g2015aug_amr	1000g2015aug_eas	1000g2015aug_eur	1000g2015aug_sas	esp6500siv2_all	esp6500siv2_ea	esp6500siv2_aa	CG69	cosmic70	ICGC_Id	ICGC_Occurrence	ClinVar_20170419	denovodb	GWAS	Segmental_duplication	Gene_score_Aggarwala	Gene_score_Petrovski	LoFtool	Deleterious_algorithm	Deleterious_vs_all_algorithms	Damaging_score	Extreme
chr10	92997	92997	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stoploss|stoploss|stoploss|stoploss	SNV	TUBB8:NM_177987:exon4:c.1335G>T:p.X445Y|ENSG00000173876:ENST00000309812:exon4:c.1335G>T:p.X445Y,ENSG00000173876:ENST00000447903:exon4:c.1119G>T:p.X373Y|TUBB8:uc001ifi.2:exon4:c.1335G>T:p.X445Y|CCDS7051.1:CCDS7051.1:exon4:c.1335G>T:p.X445Y	10p15.3	-	-	-	-	-	-	-	-	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-0.312	0.624	Tolerable	0.738	Tolerable	0.017	Tolerable	-0.541	Tolerable	0.000	Tolerable	0.075	Tolerable	0	0.109	Nonconserved	-0.291	Nonconserved	0.289	0.003	Nonconserved	0.009	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	1	1:10	1	Y
chr10	92997	92997	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stoploss|stoploss|stoploss|stoploss	SNV	TUBB8:NM_177987:exon4:c.1335G>C:p.X445Y|ENSG00000173876:ENST00000309812:exon4:c.1335G>C:p.X445Y,ENSG00000173876:ENST00000447903:exon4:c.1119G>C:p.X373Y|TUBB8:uc001ifi.2:exon4:c.1335G>C:p.X445Y|CCDS7051.1:CCDS7051.1:exon4:c.1335G>C:p.X445Y	10p15.3	-	-	-	-	-	-	-	-	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.055	3.134	Tolerable	0.730	Tolerable	0.018	Tolerable	-0.541	Tolerable	0.000	Tolerable	0.075	Tolerable	0	0.109	Nonconserved	-0.291	Nonconserved	0.289	0.003	Nonconserved	0.009	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	1	1:10	1	Y
chr10	92997	92997	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1335G>A:p.X445X|ENSG00000173876:ENST00000309812:exon4:c.1335G>A:p.X445X,ENSG00000173876:ENST00000447903:exon4:c.1119G>A:p.X373X|TUBB8:uc001ifi.2:exon4:c.1335G>A:p.X445X|CCDS7051.1:CCDS7051.1:exon4:c.1335G>A:p.X445X	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	92998	92998	T	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stoploss|stoploss|stoploss|stoploss	SNV	TUBB8:NM_177987:exon4:c.1334A>T:p.X445L|ENSG00000173876:ENST00000309812:exon4:c.1334A>T:p.X445L,ENSG00000173876:ENST00000447903:exon4:c.1118A>T:p.X373L|TUBB8:uc001ifi.2:exon4:c.1334A>T:p.X445L|CCDS7051.1:CCDS7051.1:exon4:c.1334A>T:p.X445L	10p15.3	-	-	-	-	-	-	-	-	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2.686	20.7	Damaging	0.790	Tolerable	0.638	Damaging	-0.268	Tolerable	0.000	Tolerable	0.075	Tolerable	0	0.109	Nonconserved	1.152	Nonconserved	0.321	0.566	Nonconserved	0.011	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	3	3:11	1	Y
chr10	92998	92998	T	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stoploss|stoploss|stoploss|stoploss	SNV	TUBB8:NM_177987:exon4:c.1334A>G:p.X445W|ENSG00000173876:ENST00000309812:exon4:c.1334A>G:p.X445W,ENSG00000173876:ENST00000447903:exon4:c.1118A>G:p.X373W|TUBB8:uc001ifi.2:exon4:c.1334A>G:p.X445W|CCDS7051.1:CCDS7051.1:exon4:c.1334A>G:p.X445W	10p15.3	-	-	-	-	-	-	-	-	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1.838	15.21	Tolerable	0.782	Tolerable	0.406	Tolerable	-0.268	Tolerable	0.000	Tolerable	0.075	Tolerable	0	0.109	Nonconserved	1.152	Nonconserved	0.321	0.566	Nonconserved	0.011	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	1	1:11	1	Y
chr10	92998	92998	T	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stoploss|stoploss|stoploss|stoploss	SNV	TUBB8:NM_177987:exon4:c.1334A>C:p.X445S|ENSG00000173876:ENST00000309812:exon4:c.1334A>C:p.X445S,ENSG00000173876:ENST00000447903:exon4:c.1118A>C:p.X373S|TUBB8:uc001ifi.2:exon4:c.1334A>C:p.X445S|CCDS7051.1:CCDS7051.1:exon4:c.1334A>C:p.X445S	10p15.3	-	-	-	-	-	-	-	-	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.935	10.28	Tolerable	0.633	Tolerable	0.650	Damaging	-0.268	Tolerable	0.000	Tolerable	0.075	Tolerable	0	0.109	Nonconserved	1.152	Nonconserved	0.321	0.566	Nonconserved	0.011	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:11	1	Y
chr10	92999	92999	A	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stoploss|stoploss|stoploss|stoploss	SNV	TUBB8:NM_177987:exon4:c.1333T>G:p.X445E|ENSG00000173876:ENST00000309812:exon4:c.1333T>G:p.X445E,ENSG00000173876:ENST00000447903:exon4:c.1117T>G:p.X373E|TUBB8:uc001ifi.2:exon4:c.1333T>G:p.X445E|CCDS7051.1:CCDS7051.1:exon4:c.1333T>G:p.X445E	10p15.3	-	-	-	-	-	-	-	-	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.411	6.705	Tolerable	0.702	Tolerable	0.822	Damaging	-0.194	Tolerable	0.001	Tolerable	0.075	Tolerable	0	0.109	Nonconserved	4.720	Conserved	0.357	0.647	Nonconserved	0.012	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	3	3:11	1	Y
chr10	92999	92999	A	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stoploss|stoploss|stoploss|stoploss	SNV	TUBB8:NM_177987:exon4:c.1333T>C:p.X445Q|ENSG00000173876:ENST00000309812:exon4:c.1333T>C:p.X445Q,ENSG00000173876:ENST00000447903:exon4:c.1117T>C:p.X373Q|TUBB8:uc001ifi.2:exon4:c.1333T>C:p.X445Q|CCDS7051.1:CCDS7051.1:exon4:c.1333T>C:p.X445Q	10p15.3	-	-	-	-	-	-	-	-	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.934	10.28	Tolerable	0.730	Tolerable	0.675	Damaging	-0.194	Tolerable	0.001	Tolerable	0.075	Tolerable	0	0.109	Nonconserved	4.720	Conserved	0.357	0.647	Nonconserved	0.012	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	3	3:11	1	Y
chr10	92999	92999	A	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stoploss|stoploss|stoploss|stoploss	SNV	TUBB8:NM_177987:exon4:c.1333T>A:p.X445K|ENSG00000173876:ENST00000309812:exon4:c.1333T>A:p.X445K,ENSG00000173876:ENST00000447903:exon4:c.1117T>A:p.X373K|TUBB8:uc001ifi.2:exon4:c.1333T>A:p.X445K|CCDS7051.1:CCDS7051.1:exon4:c.1333T>A:p.X445K	10p15.3	-	-	-	-	-	-	-	-	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.556	7.846	Tolerable	0.601	Tolerable	0.817	Damaging	-0.194	Tolerable	0.001	Tolerable	0.075	Tolerable	0	0.109	Nonconserved	4.720	Conserved	0.357	0.647	Nonconserved	0.012	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	3	3:11	1	Y
chr10	93000	93000	G	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1332C>T:p.A444A|ENSG00000173876:ENST00000309812:exon4:c.1332C>T:p.A444A,ENSG00000173876:ENST00000447903:exon4:c.1116C>T:p.A372A|TUBB8:uc001ifi.2:exon4:c.1332C>T:p.A444A|CCDS7051.1:CCDS7051.1:exon4:c.1332C>T:p.A444A	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	3.107e-05	0.0005	0	0	0	0	0	0	0	0.0002	0.0004	0	0	0	0	0.0001	0	-	-	Likely benign	rs554363054	0.0001	0.0015	0	0	0	0	0	0	0.0002	0.0022	0	0	0	0	0	0	0.0002	0.0015	0	0	0	0	0	0	1.29e-05	2	154602	-	-	-	-	-	-	0.000399361	0.0015	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93000	93000	G	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1332C>G:p.A444A|ENSG00000173876:ENST00000309812:exon4:c.1332C>G:p.A444A,ENSG00000173876:ENST00000447903:exon4:c.1116C>G:p.A372A|TUBB8:uc001ifi.2:exon4:c.1332C>G:p.A444A|CCDS7051.1:CCDS7051.1:exon4:c.1332C>G:p.A444A	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93000	93000	G	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1332C>A:p.A444A|ENSG00000173876:ENST00000309812:exon4:c.1332C>A:p.A444A,ENSG00000173876:ENST00000447903:exon4:c.1116C>A:p.A372A|TUBB8:uc001ifi.2:exon4:c.1332C>A:p.A444A|CCDS7051.1:CCDS7051.1:exon4:c.1332C>A:p.A444A	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93001	93001	G	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1331C>T:p.A444V|ENSG00000173876:ENST00000309812:exon4:c.1331C>T:p.A444V,ENSG00000173876:ENST00000447903:exon4:c.1115C>T:p.A372V|TUBB8:uc001ifi.2:exon4:c.1331C>T:p.A444V|CCDS7051.1:CCDS7051.1:exon4:c.1331C>T:p.A444V	10p15.3	0.002	Damaging	0.805	Possibly_damaging	0.483	Possibly_damaging	0.365	Unknown	1	Disease_causing	0	Neutral	-1.16	Tolerable	-0.26	Tolerable	0.385	Tolerable	-0.709	Tolerable	0.281	Tolerable	0.052	Damaging	2.102	16.87	Tolerable	0.665	Tolerable	0.675	Damaging	-0.752	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	2.413	Conserved	0.320	0.953	Nonconserved	0.010	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.252	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93001	93001	G	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1331C>G:p.A444G|ENSG00000173876:ENST00000309812:exon4:c.1331C>G:p.A444G,ENSG00000173876:ENST00000447903:exon4:c.1115C>G:p.A372G|TUBB8:uc001ifi.2:exon4:c.1331C>G:p.A444G|CCDS7051.1:CCDS7051.1:exon4:c.1331C>G:p.A444G	10p15.3	0.046	Damaging	0.643	Possibly_damaging	0.364	Benign	0.365	Unknown	1	Disease_causing	0	Neutral	-1.19	Tolerable	-0.19	Tolerable	0.253	Tolerable	-0.757	Tolerable	0.264	Tolerable	0.031	Damaging	0.282	5.522	Tolerable	0.597	Tolerable	0.699	Damaging	-0.822	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	2.413	Conserved	0.320	0.953	Nonconserved	0.010	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.199	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93001	93001	G	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1331C>A:p.A444D|ENSG00000173876:ENST00000309812:exon4:c.1331C>A:p.A444D,ENSG00000173876:ENST00000447903:exon4:c.1115C>A:p.A372D|TUBB8:uc001ifi.2:exon4:c.1331C>A:p.A444D|CCDS7051.1:CCDS7051.1:exon4:c.1331C>A:p.A444D	10p15.3	0.001	Damaging	0.909	Possibly_damaging	0.665	Possibly_damaging	0.365	Unknown	1	Disease_causing	0	Neutral	-1.21	Tolerable	-0.16	Tolerable	0.366	Tolerable	-0.536	Tolerable	0.322	Tolerable	0.062	Damaging	1.854	15.31	Tolerable	0.661	Tolerable	0.406	Tolerable	-0.693	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	2.413	Conserved	0.320	0.953	Nonconserved	0.010	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.269	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	4	4:23	0.17	N
chr10	93002	93002	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1330G>T:p.A444S|ENSG00000173876:ENST00000309812:exon4:c.1330G>T:p.A444S,ENSG00000173876:ENST00000447903:exon4:c.1114G>T:p.A372S|TUBB8:uc001ifi.2:exon4:c.1330G>T:p.A444S|CCDS7051.1:CCDS7051.1:exon4:c.1330G>T:p.A444S	10p15.3	0.006	Damaging	0.643	Possibly_damaging	0.364	Benign	0.365	Unknown	1	Disease_causing	0	Neutral	-1.17	Tolerable	-0.17	Tolerable	0.224	Tolerable	-0.713	Tolerable	0.268	Tolerable	0.033	Damaging	1.870	15.41	Tolerable	0.679	Tolerable	0.760	Damaging	-0.790	Tolerable	0.007	Tolerable	0.554	Tolerable	0	-	-	3.983	Conserved	0.289	0.953	Nonconserved	0.008	5.905	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.231	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:22	0.23	N
chr10	93002	93002	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1330G>C:p.A444P|ENSG00000173876:ENST00000309812:exon4:c.1330G>C:p.A444P,ENSG00000173876:ENST00000447903:exon4:c.1114G>C:p.A372P|TUBB8:uc001ifi.2:exon4:c.1330G>C:p.A444P|CCDS7051.1:CCDS7051.1:exon4:c.1330G>C:p.A444P	10p15.3	0.003	Damaging	0.909	Possibly_damaging	0.665	Possibly_damaging	0.365	Unknown	1	Disease_causing	0	Neutral	-1.23	Tolerable	-0.06	Tolerable	0.388	Tolerable	-0.584	Tolerable	0.324	Tolerable	0.058	Damaging	1.850	15.28	Tolerable	0.569	Tolerable	0.770	Damaging	-0.671	Tolerable	0.007	Tolerable	0.554	Tolerable	0	-	-	3.983	Conserved	0.289	0.953	Nonconserved	0.008	5.905	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.295	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:22	0.23	N
chr10	93002	93002	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1330G>A:p.A444T|ENSG00000173876:ENST00000309812:exon4:c.1330G>A:p.A444T,ENSG00000173876:ENST00000447903:exon4:c.1114G>A:p.A372T|TUBB8:uc001ifi.2:exon4:c.1330G>A:p.A444T|CCDS7051.1:CCDS7051.1:exon4:c.1330G>A:p.A444T	10p15.3	0.002	Damaging	0.805	Possibly_damaging	0.483	Possibly_damaging	0.365	Unknown	1	Disease_causing	0	Neutral	-1.19	Tolerable	-0.27	Tolerable	0.284	Tolerable	-0.716	Tolerable	0.283	Tolerable	0.043	Damaging	2.307	18.21	Tolerable	0.703	Tolerable	0.600	Damaging	-0.731	Tolerable	0.007	Tolerable	0.554	Tolerable	0	-	-	3.983	Conserved	0.289	0.953	Nonconserved	0.008	5.905	Nonconserved	-	6.086e-06	0	0	0.0002	0	0	0	0	0	-	-	-	-	-	-	-	-	0.253	Tolerable	Uncertain significance	rs782072300	4.731e-05	0	0	0	0	8.095e-05	0	0	-	-	-	-	-	-	-	-	6.222e-05	0	0	0	0	0.0001	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:22	0.23	N
chr10	93003	93003	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1329G>T:p.V443V|ENSG00000173876:ENST00000309812:exon4:c.1329G>T:p.V443V,ENSG00000173876:ENST00000447903:exon4:c.1113G>T:p.V371V|TUBB8:uc001ifi.2:exon4:c.1329G>T:p.V443V|CCDS7051.1:CCDS7051.1:exon4:c.1329G>T:p.V443V	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93003	93003	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1329G>C:p.V443V|ENSG00000173876:ENST00000309812:exon4:c.1329G>C:p.V443V,ENSG00000173876:ENST00000447903:exon4:c.1113G>C:p.V371V|TUBB8:uc001ifi.2:exon4:c.1329G>C:p.V443V|CCDS7051.1:CCDS7051.1:exon4:c.1329G>C:p.V443V	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93003	93003	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1329G>A:p.V443V|ENSG00000173876:ENST00000309812:exon4:c.1329G>A:p.V443V,ENSG00000173876:ENST00000447903:exon4:c.1113G>A:p.V371V|TUBB8:uc001ifi.2:exon4:c.1329G>A:p.V443V|CCDS7051.1:CCDS7051.1:exon4:c.1329G>A:p.V443V	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	rs782705179	4.531e-05	0	0	0	0	7.766e-05	0	0	-	-	-	-	-	-	-	-	5.964e-05	0	0	0	0	0.0001	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93004	93004	A	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1328T>G:p.V443G|ENSG00000173876:ENST00000309812:exon4:c.1328T>G:p.V443G,ENSG00000173876:ENST00000447903:exon4:c.1112T>G:p.V371G|TUBB8:uc001ifi.2:exon4:c.1328T>G:p.V443G|CCDS7051.1:CCDS7051.1:exon4:c.1328T>G:p.V443G	10p15.3	0.059	Tolerable	0.003	Benign	0.001	Benign	0.217	Unknown	1.000	Disease_causing	0.46	Neutral	-1.24	Tolerable	0.21	Tolerable	0.113	Tolerable	-0.741	Tolerable	0.261	Tolerable	0.172	Damaging	0.003	2.617	Tolerable	0.472	Tolerable	0.029	Tolerable	-1.337	Tolerable	0.000	Tolerable	0.554	Tolerable	0	-	-	-0.770	Nonconserved	-0.600	0.000	Nonconserved	0.008	2.164	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.153	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:22	0.09	N
chr10	93004	93004	A	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1328T>C:p.V443A|ENSG00000173876:ENST00000309812:exon4:c.1328T>C:p.V443A,ENSG00000173876:ENST00000447903:exon4:c.1112T>C:p.V371A|TUBB8:uc001ifi.2:exon4:c.1328T>C:p.V443A|CCDS7051.1:CCDS7051.1:exon4:c.1328T>C:p.V443A	10p15.3	0.091	Tolerable	0.0	Benign	0.0	Benign	0.217	Neutral	1.000	Disease_causing	0.11	Neutral	-1.17	Tolerable	0.18	Tolerable	0.093	Tolerable	-0.931	Tolerable	0.241	Tolerable	0.119	Damaging	0.046	3.041	Tolerable	0.387	Tolerable	0.007	Tolerable	-1.409	Tolerable	0.000	Tolerable	0.554	Tolerable	0	-	-	-0.770	Nonconserved	-0.600	0.000	Nonconserved	0.008	2.164	Nonconserved	-	1.171e-05	0	0	0	0	0	2.7e-05	0	0	-	-	-	-	-	-	-	-	0.169	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:22	0.09	N
chr10	93004	93004	A	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1328T>A:p.V443E|ENSG00000173876:ENST00000309812:exon4:c.1328T>A:p.V443E,ENSG00000173876:ENST00000447903:exon4:c.1112T>A:p.V371E|TUBB8:uc001ifi.2:exon4:c.1328T>A:p.V443E|CCDS7051.1:CCDS7051.1:exon4:c.1328T>A:p.V443E	10p15.3	0.122	Tolerable	0.005	Benign	0.001	Benign	0.217	Unknown	1.000	Disease_causing	-0.985	Neutral	-1.23	Tolerable	0.63	Tolerable	0.245	Tolerable	-0.916	Tolerable	0.246	Tolerable	0.110	Damaging	0.922	10.21	Tolerable	0.470	Tolerable	0.007	Tolerable	-1.386	Tolerable	0.000	Tolerable	0.554	Tolerable	0	-	-	-0.770	Nonconserved	-0.600	0.000	Nonconserved	0.008	2.164	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.219	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:22	0.09	N
chr10	93004	93007	ACCT	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonframeshift|nonframeshift|nonframeshift|nonframeshift	block substitution	TUBB8:NM_177987:exon4:c.1325_1328T|ENSG00000173876:ENST00000309812:exon4:c.1325_1328T,ENSG00000173876:ENST00000447903:exon4:c.1109_1112T|TUBB8:uc001ifi.2:exon4:c.1325_1328T|CCDS7051.1:CCDS7051.1:exon4:c.1325_1328T	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1.757e-05	9.452e-05	0	0	0	6.862e-05	0	0	4.632e-05	0	0	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93004	93031	ACCTCCTCCTCGGCATACTCCTCATCCT	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonframeshift|nonframeshift|nonframeshift|nonframeshift	block substitution	TUBB8:NM_177987:exon4:c.1301_1328T|ENSG00000173876:ENST00000309812:exon4:c.1301_1328T,ENSG00000173876:ENST00000447903:exon4:c.1085_1112T|TUBB8:uc001ifi.2:exon4:c.1301_1328T|CCDS7051.1:CCDS7051.1:exon4:c.1301_1328T	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	7.028e-05	0	0	0	0.0001	6.862e-05	0.0001	0.0002	0	3.458e-05	0	0	0	0	0	7.11e-05	0	-	-	-	rs778521360	0.0002	0	0	0	0	0.0003	0	0	0.0002	0	0	0	0	0.0005	0	0	5.758e-05	0	0	0	0	0.0001	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93005	93005	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1327G>T:p.V443L|ENSG00000173876:ENST00000309812:exon4:c.1327G>T:p.V443L,ENSG00000173876:ENST00000447903:exon4:c.1111G>T:p.V371L|TUBB8:uc001ifi.2:exon4:c.1327G>T:p.V443L|CCDS7051.1:CCDS7051.1:exon4:c.1327G>T:p.V443L	10p15.3	0.027	Damaging	0.0	Benign	0.0	Benign	0.217	Unknown	1.000	Disease_causing	0.46	Neutral	-1.11	Tolerable	-0.26	Tolerable	0.08	Tolerable	-0.901	Tolerable	0.254	Tolerable	0.037	Damaging	0.096	3.570	Tolerable	0.599	Tolerable	0.020	Tolerable	-1.330	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	2.072	Conserved	0.289	0.029	Nonconserved	0.015	2.667	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.165	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	4	4:23	0.17	N
chr10	93005	93005	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1327G>C:p.V443L|ENSG00000173876:ENST00000309812:exon4:c.1327G>C:p.V443L,ENSG00000173876:ENST00000447903:exon4:c.1111G>C:p.V371L|TUBB8:uc001ifi.2:exon4:c.1327G>C:p.V443L|CCDS7051.1:CCDS7051.1:exon4:c.1327G>C:p.V443L	10p15.3	0.027	Damaging	0.0	Benign	0.0	Benign	0.217	Unknown	1.000	Disease_causing	0.46	Neutral	-1.11	Tolerable	-0.26	Tolerable	0.08	Tolerable	-0.901	Tolerable	0.254	Tolerable	0.037	Damaging	-0.233	0.935	Tolerable	0.476	Tolerable	0.015	Tolerable	-1.330	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	2.072	Conserved	0.289	0.029	Nonconserved	0.015	2.667	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.165	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	4	4:23	0.17	N
chr10	93005	93005	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1327G>A:p.V443M|ENSG00000173876:ENST00000309812:exon4:c.1327G>A:p.V443M,ENSG00000173876:ENST00000447903:exon4:c.1111G>A:p.V371M|TUBB8:uc001ifi.2:exon4:c.1327G>A:p.V443M|CCDS7051.1:CCDS7051.1:exon4:c.1327G>A:p.V443M	10p15.3	0.02	Damaging	0.044	Benign	0.005	Benign	0.217	Unknown	1.000	Disease_causing	0.46	Neutral	-1.25	Tolerable	-0.09	Tolerable	0.093	Tolerable	-0.859	Tolerable	0.237	Tolerable	0.045	Damaging	0.105	3.667	Tolerable	0.627	Tolerable	0.015	Tolerable	-1.313	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	2.072	Conserved	0.289	0.029	Nonconserved	0.015	2.667	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.177	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	4	4:23	0.17	N
chr10	93005	93007	CCT	-	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonframeshift|nonframeshift|nonframeshift|nonframeshift	deletion	TUBB8:NM_177987:exon4:c.1325_1327del:p.442_443del|ENSG00000173876:ENST00000309812:exon4:c.1325_1327del:p.442_443del,ENSG00000173876:ENST00000447903:exon4:c.1109_1111del:p.370_371del|TUBB8:uc001ifi.2:exon4:c.1325_1327del:p.442_443del|CCDS7051.1:CCDS7051.1:exon4:c.1325_1327del:p.442_443del	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1.757e-05	9.452e-05	0	0	0	6.862e-05	0	0	4.632e-05	0	0	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93005	93031	CCTCCTCCTCGGCATACTCCTCATCCT	-	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonframeshift|nonframeshift|nonframeshift|nonframeshift	deletion	TUBB8:NM_177987:exon4:c.1301_1327del:p.434_443del|ENSG00000173876:ENST00000309812:exon4:c.1301_1327del:p.434_443del,ENSG00000173876:ENST00000447903:exon4:c.1085_1111del:p.362_371del|TUBB8:uc001ifi.2:exon4:c.1301_1327del:p.434_443del|CCDS7051.1:CCDS7051.1:exon4:c.1301_1327del:p.434_443del	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	7.028e-05	0	0	0	0.0001	6.862e-05	0.0001	0.0002	0	3.458e-05	0	0	0	0	0	7.11e-05	0	-	-	-	rs778521360	0.0002	0	0	0	0	0.0003	0	0	0.0002	0	0	0	0	0.0005	0	0	5.758e-05	0	0	0	0	0.0001	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93006	93006	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1326G>T:p.E442D|ENSG00000173876:ENST00000309812:exon4:c.1326G>T:p.E442D,ENSG00000173876:ENST00000447903:exon4:c.1110G>T:p.E370D|TUBB8:uc001ifi.2:exon4:c.1326G>T:p.E442D|CCDS7051.1:CCDS7051.1:exon4:c.1326G>T:p.E442D	10p15.3	0.066	Tolerable	0.0	Benign	0.0	Benign	0.028	Unknown	1	Disease_causing	0.78	Neutral	-0.56	Tolerable	-0.38	Tolerable	0.172	Tolerable	-0.944	Tolerable	0.167	Tolerable	0.058	Damaging	0.635	8.393	Tolerable	0.620	Tolerable	0.012	Tolerable	-1.384	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	-1.424	Nonconserved	0.289	0.021	Nonconserved	0.021	2.667	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.186	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:23	0.09	N
chr10	93006	93006	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1326G>C:p.E442D|ENSG00000173876:ENST00000309812:exon4:c.1326G>C:p.E442D,ENSG00000173876:ENST00000447903:exon4:c.1110G>C:p.E370D|TUBB8:uc001ifi.2:exon4:c.1326G>C:p.E442D|CCDS7051.1:CCDS7051.1:exon4:c.1326G>C:p.E442D	10p15.3	0.066	Tolerable	0.0	Benign	0.0	Benign	0.028	Unknown	1	Disease_causing	0.78	Neutral	-0.56	Tolerable	-0.38	Tolerable	0.172	Tolerable	-0.944	Tolerable	0.167	Tolerable	0.049	Damaging	0.219	4.879	Tolerable	0.503	Tolerable	0.034	Tolerable	-1.384	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	-1.424	Nonconserved	0.289	0.021	Nonconserved	0.021	2.667	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.186	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:23	0.09	N
chr10	93006	93006	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1326G>A:p.E442E|ENSG00000173876:ENST00000309812:exon4:c.1326G>A:p.E442E,ENSG00000173876:ENST00000447903:exon4:c.1110G>A:p.E370E|TUBB8:uc001ifi.2:exon4:c.1326G>A:p.E442E|CCDS7051.1:CCDS7051.1:exon4:c.1326G>A:p.E442E	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93006	93027	CTCCTCCTCGGCATACTCCTCA	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonframeshift|nonframeshift|nonframeshift|nonframeshift	block substitution	TUBB8:NM_177987:exon4:c.1305_1326G|ENSG00000173876:ENST00000309812:exon4:c.1305_1326G,ENSG00000173876:ENST00000447903:exon4:c.1089_1110G|TUBB8:uc001ifi.2:exon4:c.1305_1326G|CCDS7051.1:CCDS7051.1:exon4:c.1305_1326G	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	5.737e-06	0	3.844e-05	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93007	93007	T	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1325A>T:p.E442V|ENSG00000173876:ENST00000309812:exon4:c.1325A>T:p.E442V,ENSG00000173876:ENST00000447903:exon4:c.1109A>T:p.E370V|TUBB8:uc001ifi.2:exon4:c.1325A>T:p.E442V|CCDS7051.1:CCDS7051.1:exon4:c.1325A>T:p.E442V	10p15.3	0.001	Damaging	0.056	Benign	0.013	Benign	0.028	Unknown	1	Disease_causing	2.365	Medium	-0.56	Tolerable	-1.01	Tolerable	0.287	Tolerable	-0.841	Tolerable	0.194	Tolerable	0.060	Damaging	2.323	18.32	Tolerable	0.606	Tolerable	0.686	Damaging	-0.956	Tolerable	0.001	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	3.063	Conserved	0.321	0.997	Nonconserved	0.026	4.622	Nonconserved	-	5.655e-06	0	0	0	0	0	1.299e-05	0	0	-	-	-	-	-	-	-	-	0.177	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93007	93007	T	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1325A>G:p.E442G|ENSG00000173876:ENST00000309812:exon4:c.1325A>G:p.E442G,ENSG00000173876:ENST00000447903:exon4:c.1109A>G:p.E370G|TUBB8:uc001ifi.2:exon4:c.1325A>G:p.E442G|CCDS7051.1:CCDS7051.1:exon4:c.1325A>G:p.E442G	10p15.3	0.001	Damaging	0.012	Benign	0.003	Benign	0.028	Unknown	1	Disease_causing	1.33	Low	-0.6	Tolerable	-0.84	Tolerable	0.248	Tolerable	-0.846	Tolerable	0.196	Tolerable	0.060	Damaging	1.866	15.38	Tolerable	0.588	Tolerable	0.539	Damaging	-0.967	Tolerable	0.001	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	3.063	Conserved	0.321	0.997	Nonconserved	0.026	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.165	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93007	93007	T	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1325A>C:p.E442A|ENSG00000173876:ENST00000309812:exon4:c.1325A>C:p.E442A,ENSG00000173876:ENST00000447903:exon4:c.1109A>C:p.E370A|TUBB8:uc001ifi.2:exon4:c.1325A>C:p.E442A|CCDS7051.1:CCDS7051.1:exon4:c.1325A>C:p.E442A	10p15.3	0.003	Damaging	0.012	Benign	0.005	Benign	0.028	Neutral	1	Disease_causing	2.365	Medium	-0.62	Tolerable	-0.62	Tolerable	0.265	Tolerable	-0.845	Tolerable	0.198	Tolerable	0.053	Damaging	0.647	8.479	Tolerable	0.571	Tolerable	0.439	Tolerable	-0.966	Tolerable	0.001	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	3.063	Conserved	0.321	0.997	Nonconserved	0.026	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.186	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	4	4:23	0.17	N
chr10	93007	93027	TCCTCCTCGGCATACTCCTCA	-	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonframeshift|nonframeshift|nonframeshift|nonframeshift	deletion	TUBB8:NM_177987:exon4:c.1305_1325del:p.435_442del|ENSG00000173876:ENST00000309812:exon4:c.1305_1325del:p.435_442del,ENSG00000173876:ENST00000447903:exon4:c.1089_1109del:p.363_370del|TUBB8:uc001ifi.2:exon4:c.1305_1325del:p.435_442del|CCDS7051.1:CCDS7051.1:exon4:c.1305_1325del:p.435_442del	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	5.737e-06	0	3.844e-05	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93008	93008	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stopgain|stopgain|stopgain|stopgain	SNV	TUBB8:NM_177987:exon4:c.1324G>T:p.E442X|ENSG00000173876:ENST00000309812:exon4:c.1324G>T:p.E442X,ENSG00000173876:ENST00000447903:exon4:c.1108G>T:p.E370X|TUBB8:uc001ifi.2:exon4:c.1324G>T:p.E442X|CCDS7051.1:CCDS7051.1:exon4:c.1324G>T:p.E442X	10p15.3	-	-	-	-	-	-	0.028	Unknown	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	8.545	35	Damaging	0.979	Tolerable	0.524	Damaging	-0.199	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	3.980	Conserved	0.274	1.000	Conserved	0.029	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:12	1	Y
chr10	93008	93008	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1324G>C:p.E442Q|ENSG00000173876:ENST00000309812:exon4:c.1324G>C:p.E442Q,ENSG00000173876:ENST00000447903:exon4:c.1108G>C:p.E370Q|TUBB8:uc001ifi.2:exon4:c.1324G>C:p.E442Q|CCDS7051.1:CCDS7051.1:exon4:c.1324G>C:p.E442Q	10p15.3	0.167	Tolerable	0.028	Benign	0.01	Benign	0.028	Unknown	1	Disease_causing	2.02	Medium	-0.55	Tolerable	-0.48	Tolerable	0.228	Tolerable	-0.857	Tolerable	0.202	Tolerable	0.040	Damaging	0.361	6.266	Tolerable	0.599	Tolerable	0.793	Damaging	-0.930	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	3.980	Conserved	0.274	1.000	Conserved	0.029	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.205	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93008	93008	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1324G>A:p.E442K|ENSG00000173876:ENST00000309812:exon4:c.1324G>A:p.E442K,ENSG00000173876:ENST00000447903:exon4:c.1108G>A:p.E370K|TUBB8:uc001ifi.2:exon4:c.1324G>A:p.E442K|CCDS7051.1:CCDS7051.1:exon4:c.1324G>A:p.E442K	10p15.3	0.003	Damaging	0.012	Benign	0.003	Benign	0.028	Unknown	1	Disease_causing	1.82	Low	-0.59	Tolerable	-0.74	Tolerable	0.282	Tolerable	-0.848	Tolerable	0.201	Tolerable	0.036	Damaging	1.320	12.37	Tolerable	0.663	Tolerable	0.763	Damaging	-0.938	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	3.980	Conserved	0.274	1.000	Conserved	0.029	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.214	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	6	6:23	0.26	N
chr10	93008	93020	CCTCCTCGGCATA	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonframeshift|nonframeshift|nonframeshift|nonframeshift	block substitution	TUBB8:NM_177987:exon4:c.1312_1324G|ENSG00000173876:ENST00000309812:exon4:c.1312_1324G,ENSG00000173876:ENST00000447903:exon4:c.1096_1108G|TUBB8:uc001ifi.2:exon4:c.1312_1324G|CCDS7051.1:CCDS7051.1:exon4:c.1312_1324G	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	5.588e-06	0	0	0	0	0	1.284e-05	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93009	93009	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1323G>T:p.E441D|ENSG00000173876:ENST00000309812:exon4:c.1323G>T:p.E441D,ENSG00000173876:ENST00000447903:exon4:c.1107G>T:p.E369D|TUBB8:uc001ifi.2:exon4:c.1323G>T:p.E441D|CCDS7051.1:CCDS7051.1:exon4:c.1323G>T:p.E441D	10p15.3	0.053	Tolerable	0.0	Benign	0.0	Benign	0.310	Unknown	1	Disease_causing	1.525	Low	-0.63	Tolerable	-0.33	Tolerable	0.183	Tolerable	-0.939	Tolerable	0.202	Tolerable	0.013	Tolerable	0.622	8.310	Tolerable	0.656	Tolerable	0.471	Tolerable	-1.065	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	0.021	Nonconserved	0.274	0.983	Nonconserved	0.031	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.224	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	1	1:23	0.04	N
chr10	93009	93009	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1323G>C:p.E441D|ENSG00000173876:ENST00000309812:exon4:c.1323G>C:p.E441D,ENSG00000173876:ENST00000447903:exon4:c.1107G>C:p.E369D|TUBB8:uc001ifi.2:exon4:c.1323G>C:p.E441D|CCDS7051.1:CCDS7051.1:exon4:c.1323G>C:p.E441D	10p15.3	0.053	Tolerable	0.0	Benign	0.0	Benign	0.310	Unknown	1	Disease_causing	1.525	Low	-0.63	Tolerable	-0.33	Tolerable	0.183	Tolerable	-0.939	Tolerable	0.202	Tolerable	0.011	Tolerable	0.369	6.338	Tolerable	0.576	Tolerable	0.305	Tolerable	-1.065	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	0.021	Nonconserved	0.274	0.983	Nonconserved	0.031	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.224	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	1	1:23	0.04	N
chr10	93009	93009	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1323G>A:p.E441E|ENSG00000173876:ENST00000309812:exon4:c.1323G>A:p.E441E,ENSG00000173876:ENST00000447903:exon4:c.1107G>A:p.E369E|TUBB8:uc001ifi.2:exon4:c.1323G>A:p.E441E|CCDS7051.1:CCDS7051.1:exon4:c.1323G>A:p.E441E	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93009	93020	CTCCTCGGCATA	-	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonframeshift|nonframeshift|nonframeshift|nonframeshift	deletion	TUBB8:NM_177987:exon4:c.1312_1323del:p.438_441del|ENSG00000173876:ENST00000309812:exon4:c.1312_1323del:p.438_441del,ENSG00000173876:ENST00000447903:exon4:c.1096_1107del:p.366_369del|TUBB8:uc001ifi.2:exon4:c.1312_1323del:p.438_441del|CCDS7051.1:CCDS7051.1:exon4:c.1312_1323del:p.438_441del	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	5.588e-06	0	0	0	0	0	1.284e-05	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93010	93010	-	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	frameshift|frameshift|frameshift|frameshift	insertion	TUBB8:NM_177987:exon4:c.1321dupG:p.E441fs|ENSG00000173876:ENST00000309812:exon4:c.1321dupG:p.E441fs,ENSG00000173876:ENST00000447903:exon4:c.1105dupG:p.E369fs|TUBB8:uc001ifi.2:exon4:c.1321dupG:p.E441fs|CCDS7051.1:CCDS7051.1:exon4:c.1321dupG:p.E441fs	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1.088e-05	0	0	0	0	0	2.497e-05	0	0	-	-	-	-	-	-	-	-	-	-	-	rs782210758	7.567e-05	0	0	0	0	0.0001	0	0	-	-	-	-	-	-	-	-	0.0001	0	0	0	0	0.0002	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	1	Y
chr10	93010	93010	T	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1322A>T:p.E441V|ENSG00000173876:ENST00000309812:exon4:c.1322A>T:p.E441V,ENSG00000173876:ENST00000447903:exon4:c.1106A>T:p.E369V|TUBB8:uc001ifi.2:exon4:c.1322A>T:p.E441V|CCDS7051.1:CCDS7051.1:exon4:c.1322A>T:p.E441V	10p15.3	0.002	Damaging	0.056	Benign	0.013	Benign	0.310	Neutral	1	Disease_causing	2.705	Medium	-0.66	Tolerable	-1.26	Tolerable	0.312	Tolerable	-0.810	Tolerable	0.202	Tolerable	0.019	Tolerable	2.297	18.15	Tolerable	0.590	Tolerable	0.885	Damaging	-0.833	Tolerable	0.001	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.653	Conserved	0.304	1.000	Conserved	0.032	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.205	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93010	93010	T	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1322A>G:p.E441G|ENSG00000173876:ENST00000309812:exon4:c.1322A>G:p.E441G,ENSG00000173876:ENST00000447903:exon4:c.1106A>G:p.E369G|TUBB8:uc001ifi.2:exon4:c.1322A>G:p.E441G|CCDS7051.1:CCDS7051.1:exon4:c.1322A>G:p.E441G	10p15.3	0.032	Damaging	0.012	Benign	0.003	Benign	0.310	Unknown	1	Disease_causing	2.045	Medium	-0.62	Tolerable	-0.94	Tolerable	0.255	Tolerable	-0.882	Tolerable	0.198	Tolerable	0.015	Tolerable	0.746	9.125	Tolerable	0.560	Tolerable	0.879	Damaging	-0.871	Tolerable	0.001	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.653	Conserved	0.304	1.000	Conserved	0.032	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.224	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93010	93010	T	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1322A>C:p.E441A|ENSG00000173876:ENST00000309812:exon4:c.1322A>C:p.E441A,ENSG00000173876:ENST00000447903:exon4:c.1106A>C:p.E369A|TUBB8:uc001ifi.2:exon4:c.1322A>C:p.E441A|CCDS7051.1:CCDS7051.1:exon4:c.1322A>C:p.E441A	10p15.3	0.083	Tolerable	0.012	Benign	0.005	Benign	0.310	Unknown	1	Disease_causing	2.155	Medium	-0.37	Tolerable	-0.86	Tolerable	0.254	Tolerable	-0.958	Tolerable	0.159	Tolerable	0.013	Tolerable	0.631	8.366	Tolerable	0.548	Tolerable	0.888	Damaging	-0.938	Tolerable	0.001	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.653	Conserved	0.304	1.000	Conserved	0.032	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.224	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	4	4:23	0.17	N
chr10	93010	93010	T	TC	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	frameshift|frameshift|frameshift|frameshift	block substitution	TUBB8:NM_177987:exon4:c.1322_1322delinsGA|ENSG00000173876:ENST00000309812:exon4:c.1322_1322delinsGA,ENSG00000173876:ENST00000447903:exon4:c.1106_1106delinsGA|TUBB8:uc001ifi.2:exon4:c.1322_1322delinsGA|CCDS7051.1:CCDS7051.1:exon4:c.1322_1322delinsGA	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1.088e-05	0	0	0	0	0	2.497e-05	0	0	-	-	-	-	-	-	-	-	-	-	-	rs782210758	7.567e-05	0	0	0	0	0.0001	0	0	-	-	-	-	-	-	-	-	0.0001	0	0	0	0	0.0002	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	1	Y
chr10	93011	93011	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stopgain|stopgain|stopgain|stopgain	SNV	TUBB8:NM_177987:exon4:c.1321G>T:p.E441X|ENSG00000173876:ENST00000309812:exon4:c.1321G>T:p.E441X,ENSG00000173876:ENST00000447903:exon4:c.1105G>T:p.E369X|TUBB8:uc001ifi.2:exon4:c.1321G>T:p.E441X|CCDS7051.1:CCDS7051.1:exon4:c.1321G>T:p.E441X	10p15.3	-	-	-	-	-	-	0.310	Unknown	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	8.509	35	Damaging	0.978	Tolerable	0.718	Damaging	-0.249	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	3.894	Conserved	0.280	1.000	Conserved	0.023	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:12	1	Y
chr10	93011	93011	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1321G>C:p.E441Q|ENSG00000173876:ENST00000309812:exon4:c.1321G>C:p.E441Q,ENSG00000173876:ENST00000447903:exon4:c.1105G>C:p.E369Q|TUBB8:uc001ifi.2:exon4:c.1321G>C:p.E441Q|CCDS7051.1:CCDS7051.1:exon4:c.1321G>C:p.E441Q	10p15.3	0.112	Tolerable	0.028	Benign	0.01	Benign	0.310	Unknown	1	Disease_causing	2.705	Medium	-0.55	Tolerable	-0.47	Tolerable	0.205	Tolerable	-0.875	Tolerable	0.204	Tolerable	0.014	Tolerable	0.308	5.770	Tolerable	0.576	Tolerable	0.702	Damaging	-0.913	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	3.894	Conserved	0.280	1.000	Conserved	0.023	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.198	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	4	4:23	0.17	N
chr10	93011	93011	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1321G>A:p.E441K|ENSG00000173876:ENST00000309812:exon4:c.1321G>A:p.E441K,ENSG00000173876:ENST00000447903:exon4:c.1105G>A:p.E369K|TUBB8:uc001ifi.2:exon4:c.1321G>A:p.E441K|CCDS7051.1:CCDS7051.1:exon4:c.1321G>A:p.E441K	10p15.3	0.028	Damaging	0.012	Benign	0.003	Benign	0.310	Unknown	1	Disease_causing	3.395	Medium	-0.57	Tolerable	-0.77	Tolerable	0.333	Tolerable	-0.841	Tolerable	0.202	Tolerable	0.020	Tolerable	1.615	13.93	Tolerable	0.655	Tolerable	0.676	Damaging	-0.927	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	3.894	Conserved	0.280	1.000	Conserved	0.023	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.160	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93012	93012	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1320G>T:p.E440D|ENSG00000173876:ENST00000309812:exon4:c.1320G>T:p.E440D,ENSG00000173876:ENST00000447903:exon4:c.1104G>T:p.E368D|TUBB8:uc001ifi.2:exon4:c.1320G>T:p.E440D|CCDS7051.1:CCDS7051.1:exon4:c.1320G>T:p.E440D	10p15.3	0.104	Tolerable	0.267	Benign	0.217	Benign	0.097	Neutral	1	Disease_causing	0.525	Neutral	-0.52	Tolerable	-0.39	Tolerable	0.286	Tolerable	-0.920	Tolerable	0.165	Tolerable	0.010	Tolerable	0.371	6.360	Tolerable	0.635	Tolerable	0.509	Damaging	-1.034	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	0.682	Nonconserved	0.280	1.000	Conserved	0.020	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.101	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	3	3:23	0.13	N
chr10	93012	93012	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1320G>C:p.E440D|ENSG00000173876:ENST00000309812:exon4:c.1320G>C:p.E440D,ENSG00000173876:ENST00000447903:exon4:c.1104G>C:p.E368D|TUBB8:uc001ifi.2:exon4:c.1320G>C:p.E440D|CCDS7051.1:CCDS7051.1:exon4:c.1320G>C:p.E440D	10p15.3	0.104	Tolerable	0.267	Benign	0.217	Benign	0.097	Neutral	1	Disease_causing	0.525	Neutral	-0.52	Tolerable	-0.39	Tolerable	0.286	Tolerable	-0.917	Tolerable	0.165	Tolerable	0.010	Tolerable	0.118	3.799	Tolerable	0.559	Tolerable	0.549	Damaging	-1.034	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	0.682	Nonconserved	0.280	1.000	Conserved	0.020	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.101	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	3	3:23	0.13	N
chr10	93012	93012	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1320G>A:p.E440E|ENSG00000173876:ENST00000309812:exon4:c.1320G>A:p.E440E,ENSG00000173876:ENST00000447903:exon4:c.1104G>A:p.E368E|TUBB8:uc001ifi.2:exon4:c.1320G>A:p.E440E|CCDS7051.1:CCDS7051.1:exon4:c.1320G>A:p.E440E	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93013	93013	T	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1319A>T:p.E440V|ENSG00000173876:ENST00000309812:exon4:c.1319A>T:p.E440V,ENSG00000173876:ENST00000447903:exon4:c.1103A>T:p.E368V|TUBB8:uc001ifi.2:exon4:c.1319A>T:p.E440V|CCDS7051.1:CCDS7051.1:exon4:c.1319A>T:p.E440V	10p15.3	0.001	Damaging	0.824	Possibly_damaging	0.403	Benign	0.097	Unknown	1	Disease_causing	1.625	Low	-0.59	Tolerable	-1.37	Tolerable	0.399	Tolerable	-0.802	Tolerable	0.207	Tolerable	0.019	Tolerable	1.195	11.72	Tolerable	0.562	Tolerable	0.635	Damaging	-0.705	Tolerable	0.001	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	3.059	Conserved	0.310	1.000	Conserved	0.015	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.159	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93013	93013	T	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1319A>G:p.E440G|ENSG00000173876:ENST00000309812:exon4:c.1319A>G:p.E440G,ENSG00000173876:ENST00000447903:exon4:c.1103A>G:p.E368G|TUBB8:uc001ifi.2:exon4:c.1319A>G:p.E440G|CCDS7051.1:CCDS7051.1:exon4:c.1319A>G:p.E440G	10p15.3	0.022	Damaging	0.659	Possibly_damaging	0.403	Benign	0.097	Unknown	1	Disease_causing	0.85	Low	-0.6	Tolerable	-1.01	Tolerable	0.324	Tolerable	-0.806	Tolerable	0.212	Tolerable	0.020	Tolerable	0.669	8.626	Tolerable	0.511	Tolerable	0.552	Damaging	-0.773	Tolerable	0.001	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	3.059	Conserved	0.310	1.000	Conserved	0.015	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.179	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93013	93013	T	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1319A>C:p.E440A|ENSG00000173876:ENST00000309812:exon4:c.1319A>C:p.E440A,ENSG00000173876:ENST00000447903:exon4:c.1103A>C:p.E368A|TUBB8:uc001ifi.2:exon4:c.1319A>C:p.E440A|CCDS7051.1:CCDS7051.1:exon4:c.1319A>C:p.E440A	10p15.3	0.004	Damaging	0.458	Possibly_damaging	0.292	Benign	0.097	Unknown	1	Disease_causing	1.735	Low	-0.53	Tolerable	-1.04	Tolerable	0.359	Tolerable	-0.848	Tolerable	0.203	Tolerable	0.016	Tolerable	0.659	8.559	Tolerable	0.500	Tolerable	0.650	Damaging	-0.842	Tolerable	0.001	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	3.059	Conserved	0.310	1.000	Conserved	0.015	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.149	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93014	93014	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stopgain|stopgain|stopgain|stopgain	SNV	TUBB8:NM_177987:exon4:c.1318G>T:p.E440X|ENSG00000173876:ENST00000309812:exon4:c.1318G>T:p.E440X,ENSG00000173876:ENST00000447903:exon4:c.1102G>T:p.E368X|TUBB8:uc001ifi.2:exon4:c.1318G>T:p.E440X|CCDS7051.1:CCDS7051.1:exon4:c.1318G>T:p.E440X	10p15.3	-	-	-	-	-	-	0.097	Unknown	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	8.785	35	Damaging	0.978	Tolerable	0.785	Damaging	-0.237	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.576	Conserved	0.280	1.000	Conserved	0.009	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:12	1	Y
chr10	93014	93014	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1318G>C:p.E440Q|ENSG00000173876:ENST00000309812:exon4:c.1318G>C:p.E440Q,ENSG00000173876:ENST00000447903:exon4:c.1102G>C:p.E368Q|TUBB8:uc001ifi.2:exon4:c.1318G>C:p.E440Q|CCDS7051.1:CCDS7051.1:exon4:c.1318G>C:p.E440Q	10p15.3	0.102	Tolerable	0.831	Possibly_damaging	0.557	Possibly_damaging	0.097	Unknown	1	Disease_causing	2.08	Medium	-0.6	Tolerable	-0.63	Tolerable	0.264	Tolerable	-0.669	Tolerable	0.237	Tolerable	0.013	Tolerable	0.496	7.398	Tolerable	0.519	Tolerable	0.794	Damaging	-0.637	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.576	Conserved	0.280	1.000	Conserved	0.009	5.991	Nonconserved	-	5.237e-06	0	0	0	6.852e-05	0	0	0	0	-	-	-	-	-	-	-	-	0.242	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	4	4:23	0.17	N
chr10	93014	93014	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1318G>A:p.E440K|ENSG00000173876:ENST00000309812:exon4:c.1318G>A:p.E440K,ENSG00000173876:ENST00000447903:exon4:c.1102G>A:p.E368K|TUBB8:uc001ifi.2:exon4:c.1318G>A:p.E440K|CCDS7051.1:CCDS7051.1:exon4:c.1318G>A:p.E440K	10p15.3	0.004	Damaging	0.826	Possibly_damaging	0.305	Benign	0.097	Unknown	1	Disease_causing	2.625	Medium	-0.58	Tolerable	-0.92	Tolerable	0.411	Tolerable	-0.849	Tolerable	0.182	Tolerable	0.016	Tolerable	1.665	14.21	Tolerable	0.621	Tolerable	0.748	Damaging	-0.695	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.576	Conserved	0.280	1.000	Conserved	0.009	5.991	Nonconserved	-	5.237e-06	0	0	0	0	0	1.197e-05	0	0	-	-	-	-	-	-	-	-	0.232	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93015	93015	G	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1317C>T:p.A439A|ENSG00000173876:ENST00000309812:exon4:c.1317C>T:p.A439A,ENSG00000173876:ENST00000447903:exon4:c.1101C>T:p.A367A|TUBB8:uc001ifi.2:exon4:c.1317C>T:p.A439A|CCDS7051.1:CCDS7051.1:exon4:c.1317C>T:p.A439A	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	5.166e-06	0	0	0.0001	0	0	0	0	0	0.0001	0.0003	0	0	0	0	7.422e-05	0	-	-	Likely benign	rs781838823	6.576e-05	0	0	0	0	5.762e-05	0	0.0002	8.548e-05	0	0	0	0	8.546e-05	0	0.0002	8.814e-05	0	0	0	0	9.136e-05	0	0.0002	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93015	93015	G	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1317C>G:p.A439A|ENSG00000173876:ENST00000309812:exon4:c.1317C>G:p.A439A,ENSG00000173876:ENST00000447903:exon4:c.1101C>G:p.A367A|TUBB8:uc001ifi.2:exon4:c.1317C>G:p.A439A|CCDS7051.1:CCDS7051.1:exon4:c.1317C>G:p.A439A	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93015	93015	G	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1317C>A:p.A439A|ENSG00000173876:ENST00000309812:exon4:c.1317C>A:p.A439A,ENSG00000173876:ENST00000447903:exon4:c.1101C>A:p.A367A|TUBB8:uc001ifi.2:exon4:c.1317C>A:p.A439A|CCDS7051.1:CCDS7051.1:exon4:c.1317C>A:p.A439A	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	5.166e-06	0	0	0	0	0	1.179e-05	0	0	-	-	-	-	-	-	-	-	-	-	Likely benign	rs781838823	3.288e-05	-	-	-	-	-	-	-	4.274e-05	0	0	0	0	8.546e-05	0	0	4.407e-05	0	0	0	0	9.136e-05	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93016	93016	G	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1316C>T:p.A439V|ENSG00000173876:ENST00000309812:exon4:c.1316C>T:p.A439V,ENSG00000173876:ENST00000447903:exon4:c.1100C>T:p.A367V|TUBB8:uc001ifi.2:exon4:c.1316C>T:p.A439V|CCDS7051.1:CCDS7051.1:exon4:c.1316C>T:p.A439V	10p15.3	0.038	Damaging	0.0	Benign	0.0	Benign	0.028	Unknown	1	Disease_causing	1.115	Low	-0.56	Tolerable	-0.47	Tolerable	0.104	Tolerable	-1.027	Tolerable	0.150	Tolerable	0.018	Tolerable	-0.887	0.028	Tolerable	0.381	Tolerable	0.009	Tolerable	-1.721	Tolerable	0.000	Tolerable	0.554	Tolerable	0	-0.218	Nonconserved	-0.720	Nonconserved	-0.652	0.000	Nonconserved	0.001	4.308	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.105	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:23	0.09	N
chr10	93016	93016	G	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1316C>G:p.A439G|ENSG00000173876:ENST00000309812:exon4:c.1316C>G:p.A439G,ENSG00000173876:ENST00000447903:exon4:c.1100C>G:p.A367G|TUBB8:uc001ifi.2:exon4:c.1316C>G:p.A439G|CCDS7051.1:CCDS7051.1:exon4:c.1316C>G:p.A439G	10p15.3	0.06	Tolerable	0.0	Benign	0.0	Benign	0.028	Unknown	1	Disease_causing	0.63	Neutral	-0.32	Tolerable	0.0	Tolerable	0.08	Tolerable	-1.056	Tolerable	0.112	Tolerable	0.015	Tolerable	-1.649	0.002	Tolerable	0.297	Tolerable	0.005	Tolerable	-1.767	Tolerable	0.000	Tolerable	0.554	Tolerable	0	-0.218	Nonconserved	-0.720	Nonconserved	-0.652	0.000	Nonconserved	0.001	4.308	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.082	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	1	1:23	0.04	N
chr10	93016	93016	G	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1316C>A:p.A439D|ENSG00000173876:ENST00000309812:exon4:c.1316C>A:p.A439D,ENSG00000173876:ENST00000447903:exon4:c.1100C>A:p.A367D|TUBB8:uc001ifi.2:exon4:c.1316C>A:p.A439D|CCDS7051.1:CCDS7051.1:exon4:c.1316C>A:p.A439D	10p15.3	0.169	Tolerable	0.003	Benign	0.002	Benign	0.028	Neutral	1	Disease_causing	0.205	Neutral	-0.45	Tolerable	0.31	Tolerable	0.157	Tolerable	-1.038	Tolerable	0.086	Tolerable	0.017	Tolerable	-1.650	0.002	Tolerable	0.312	Tolerable	0.005	Tolerable	-1.858	Tolerable	0.000	Tolerable	0.554	Tolerable	0	-0.218	Nonconserved	-0.720	Nonconserved	-0.652	0.000	Nonconserved	0.001	4.308	Nonconserved	-	5.075e-06	0	0	0	0	0	1.161e-05	0	0	-	-	-	-	-	-	-	-	0.059	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	1	1:23	0.04	N
chr10	93017	93017	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1315G>T:p.A439S|ENSG00000173876:ENST00000309812:exon4:c.1315G>T:p.A439S,ENSG00000173876:ENST00000447903:exon4:c.1099G>T:p.A367S|TUBB8:uc001ifi.2:exon4:c.1315G>T:p.A439S|CCDS7051.1:CCDS7051.1:exon4:c.1315G>T:p.A439S	10p15.3	0.301	Tolerable	0.003	Benign	0.002	Benign	0.028	Unknown	1	Disease_causing	1.665	Low	-0.41	Tolerable	-0.09	Tolerable	0.137	Tolerable	-1.044	Tolerable	0.125	Tolerable	0.015	Tolerable	-0.312	0.624	Tolerable	0.589	Tolerable	0.320	Tolerable	-1.168	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.576	Conserved	0.280	0.408	Nonconserved	0.002	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.170	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:23	0.09	N
chr10	93017	93017	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1315G>C:p.A439P|ENSG00000173876:ENST00000309812:exon4:c.1315G>C:p.A439P,ENSG00000173876:ENST00000447903:exon4:c.1099G>C:p.A367P|TUBB8:uc001ifi.2:exon4:c.1315G>C:p.A439P|CCDS7051.1:CCDS7051.1:exon4:c.1315G>C:p.A439P	10p15.3	0.046	Damaging	0.026	Benign	0.006	Benign	0.028	Unknown	1	Disease_causing	1.525	Low	-0.55	Tolerable	-0.41	Tolerable	0.214	Tolerable	-0.987	Tolerable	0.155	Tolerable	0.013	Tolerable	0.373	6.371	Tolerable	0.536	Tolerable	0.332	Tolerable	-1.111	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.576	Conserved	0.280	0.408	Nonconserved	0.002	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.177	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	3	3:23	0.13	N
chr10	93017	93017	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1315G>A:p.A439T|ENSG00000173876:ENST00000309812:exon4:c.1315G>A:p.A439T,ENSG00000173876:ENST00000447903:exon4:c.1099G>A:p.A367T|TUBB8:uc001ifi.2:exon4:c.1315G>A:p.A439T|CCDS7051.1:CCDS7051.1:exon4:c.1315G>A:p.A439T	10p15.3	0.062	Tolerable	0.005	Benign	0.002	Benign	0.028	Unknown	1	Disease_causing	2.215	Medium	-0.45	Tolerable	-0.39	Tolerable	0.074	Tolerable	-1.041	Tolerable	0.126	Tolerable	0.014	Tolerable	0.348	6.148	Tolerable	0.601	Tolerable	0.277	Tolerable	-1.154	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.576	Conserved	0.280	0.408	Nonconserved	0.002	5.991	Nonconserved	-	5.481e-05	0	0	0	0	0	0	0	0.0004	-	-	-	-	-	-	-	-	0.177	Tolerable	Uncertain significance	rs782770339	0.0001	0	0	0	0	0	0	0.0008	0.0001	0	0	0	0	0	0	0.0008	0.0002	0	0	0	0	0	0	0.0008	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:23	0.09	N
chr10	93018	93018	A	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stopgain|stopgain|stopgain|stopgain	SNV	TUBB8:NM_177987:exon4:c.1314T>G:p.Y438X|ENSG00000173876:ENST00000309812:exon4:c.1314T>G:p.Y438X,ENSG00000173876:ENST00000447903:exon4:c.1098T>G:p.Y366X|TUBB8:uc001ifi.2:exon4:c.1314T>G:p.Y438X|CCDS7051.1:CCDS7051.1:exon4:c.1314T>G:p.Y438X	10p15.3	-	-	-	-	-	-	0.000	Unknown	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	8.815	35	Damaging	0.956	Tolerable	0.003	Tolerable	-0.750	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	-0.081	Nonconserved	0.345	0.267	Nonconserved	0.001	2.907	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:12	1	Y
chr10	93018	93018	A	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1314T>C:p.Y438Y|ENSG00000173876:ENST00000309812:exon4:c.1314T>C:p.Y438Y,ENSG00000173876:ENST00000447903:exon4:c.1098T>C:p.Y366Y|TUBB8:uc001ifi.2:exon4:c.1314T>C:p.Y438Y|CCDS7051.1:CCDS7051.1:exon4:c.1314T>C:p.Y438Y	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93018	93018	A	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stopgain|stopgain|stopgain|stopgain	SNV	TUBB8:NM_177987:exon4:c.1314T>A:p.Y438X|ENSG00000173876:ENST00000309812:exon4:c.1314T>A:p.Y438X,ENSG00000173876:ENST00000447903:exon4:c.1098T>A:p.Y366X|TUBB8:uc001ifi.2:exon4:c.1314T>A:p.Y438X|CCDS7051.1:CCDS7051.1:exon4:c.1314T>A:p.Y438X	10p15.3	-	-	-	-	-	-	0.000	Unknown	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	9.174	35	Damaging	0.956	Tolerable	0.013	Tolerable	-0.750	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	-0.081	Nonconserved	0.345	0.267	Nonconserved	0.001	2.907	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:12	1	Y
chr10	93019	93019	T	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1313A>T:p.Y438F|ENSG00000173876:ENST00000309812:exon4:c.1313A>T:p.Y438F,ENSG00000173876:ENST00000447903:exon4:c.1097A>T:p.Y366F|TUBB8:uc001ifi.2:exon4:c.1313A>T:p.Y438F|CCDS7051.1:CCDS7051.1:exon4:c.1313A>T:p.Y438F	10p15.3	0.397	Tolerable	0.032	Benign	0.006	Benign	0.000	Unknown	1	Disease_causing	1.21	Low	-0.51	Tolerable	-0.3	Tolerable	0.163	Tolerable	-1.020	Tolerable	0.227	Tolerable	0.068	Damaging	-1.602	0.002	Tolerable	0.219	Tolerable	0.461	Tolerable	-1.505	Tolerable	0.000	Tolerable	0.554	Tolerable	0	-0.218	Nonconserved	1.750	Nonconserved	-2.998	0.996	Nonconserved	0.000	4.690	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.161	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:23	0.09	N
chr10	93019	93019	T	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1313A>G:p.Y438C|ENSG00000173876:ENST00000309812:exon4:c.1313A>G:p.Y438C,ENSG00000173876:ENST00000447903:exon4:c.1097A>G:p.Y366C|TUBB8:uc001ifi.2:exon4:c.1313A>G:p.Y438C|CCDS7051.1:CCDS7051.1:exon4:c.1313A>G:p.Y438C	10p15.3	0.117	Tolerable	0.516	Possibly_damaging	0.039	Benign	0.000	Neutral	1	Disease_causing	3.21	Medium	-0.51	Tolerable	-0.53	Tolerable	0.164	Tolerable	-0.994	Tolerable	0.214	Tolerable	0.034	Damaging	-1.129	0.009	Tolerable	0.136	Tolerable	0.318	Tolerable	-1.304	Tolerable	0.000	Tolerable	0.554	Tolerable	0	-0.218	Nonconserved	1.750	Nonconserved	-2.998	0.996	Nonconserved	0.000	4.690	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.192	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:23	0.09	N
chr10	93019	93019	T	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1313A>C:p.Y438S|ENSG00000173876:ENST00000309812:exon4:c.1313A>C:p.Y438S,ENSG00000173876:ENST00000447903:exon4:c.1097A>C:p.Y366S|TUBB8:uc001ifi.2:exon4:c.1313A>C:p.Y438S|CCDS7051.1:CCDS7051.1:exon4:c.1313A>C:p.Y438S	10p15.3	0.175	Tolerable	0.001	Benign	0.001	Benign	0.000	Unknown	1	Disease_causing	2.865	Medium	-0.32	Tolerable	-0.03	Tolerable	0.195	Tolerable	-1.065	Tolerable	0.207	Tolerable	0.037	Damaging	-0.830	0.037	Tolerable	0.311	Tolerable	0.478	Tolerable	-1.457	Tolerable	0.000	Tolerable	0.554	Tolerable	0	-0.218	Nonconserved	1.750	Nonconserved	-2.998	0.996	Nonconserved	0.000	4.690	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.175	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	2	2:23	0.09	N
chr10	93020	93020	A	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1312T>G:p.Y438D|ENSG00000173876:ENST00000309812:exon4:c.1312T>G:p.Y438D,ENSG00000173876:ENST00000447903:exon4:c.1096T>G:p.Y366D|TUBB8:uc001ifi.2:exon4:c.1312T>G:p.Y438D|CCDS7051.1:CCDS7051.1:exon4:c.1312T>G:p.Y438D	10p15.3	0.126	Tolerable	0.001	Benign	0.001	Benign	0.000	Unknown	1	Disease_causing	1.075	Low	-0.47	Tolerable	0.57	Tolerable	0.131	Tolerable	-1.016	Tolerable	0.206	Tolerable	0.060	Damaging	-1.262	0.005	Tolerable	0.168	Tolerable	0.010	Tolerable	-1.476	Tolerable	0.000	Tolerable	0.554	Tolerable	0	-0.218	Nonconserved	2.956	Conserved	-0.582	0.998	Nonconserved	0.001	4.992	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.185	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	3	3:23	0.13	N
chr10	93020	93020	A	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1312T>C:p.Y438H|ENSG00000173876:ENST00000309812:exon4:c.1312T>C:p.Y438H,ENSG00000173876:ENST00000447903:exon4:c.1096T>C:p.Y366H|TUBB8:uc001ifi.2:exon4:c.1312T>C:p.Y438H|CCDS7051.1:CCDS7051.1:exon4:c.1312T>C:p.Y438H	10p15.3	0.244	Tolerable	0.085	Benign	0.013	Benign	0.000	Unknown	1	Disease_causing	2.865	Medium	-0.45	Tolerable	0.01	Tolerable	0.153	Tolerable	-1.059	Tolerable	0.199	Tolerable	0.087	Damaging	-1.670	0.002	Tolerable	0.216	Tolerable	0.292	Tolerable	-1.469	Tolerable	0.000	Tolerable	0.554	Tolerable	0	-0.218	Nonconserved	2.956	Conserved	-0.582	0.998	Nonconserved	0.001	4.992	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.182	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	3	3:23	0.13	N
chr10	93020	93020	A	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1312T>A:p.Y438N|ENSG00000173876:ENST00000309812:exon4:c.1312T>A:p.Y438N,ENSG00000173876:ENST00000447903:exon4:c.1096T>A:p.Y366N|TUBB8:uc001ifi.2:exon4:c.1312T>A:p.Y438N|CCDS7051.1:CCDS7051.1:exon4:c.1312T>A:p.Y438N	10p15.3	0.146	Tolerable	0.005	Benign	0.002	Benign	0.000	Unknown	1	Disease_causing	2.31	Medium	-0.41	Tolerable	-0.03	Tolerable	0.2	Tolerable	-1.056	Tolerable	0.212	Tolerable	0.074	Damaging	-1.351	0.004	Tolerable	0.244	Tolerable	0.244	Tolerable	-1.446	Tolerable	0.000	Tolerable	0.554	Tolerable	0	-0.218	Nonconserved	2.956	Conserved	-0.582	0.998	Nonconserved	0.001	4.992	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.216	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	3	3:23	0.13	N
chr10	93020	93023	ACTC	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonframeshift|nonframeshift|nonframeshift|nonframeshift	block substitution	TUBB8:NM_177987:exon4:c.1309_1312T|ENSG00000173876:ENST00000309812:exon4:c.1309_1312T,ENSG00000173876:ENST00000447903:exon4:c.1093_1096T|TUBB8:uc001ifi.2:exon4:c.1309_1312T|CCDS7051.1:CCDS7051.1:exon4:c.1309_1312T	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	4.809e-06	0	0	0	0	0	1.096e-05	0	0	3.529e-05	0.0001	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93021	93021	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1311G>T:p.E437D|ENSG00000173876:ENST00000309812:exon4:c.1311G>T:p.E437D,ENSG00000173876:ENST00000447903:exon4:c.1095G>T:p.E365D|TUBB8:uc001ifi.2:exon4:c.1311G>T:p.E437D|CCDS7051.1:CCDS7051.1:exon4:c.1311G>T:p.E437D	10p15.3	0.151	Tolerable	0.267	Benign	0.217	Benign	0.246	Unknown	1	Disease_causing	1.055	Low	-0.71	Tolerable	-0.46	Tolerable	0.311	Tolerable	-0.984	Tolerable	0.133	Tolerable	0.012	Tolerable	0.302	5.717	Tolerable	0.514	Tolerable	0.279	Tolerable	-1.143	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	0.094	Nonconserved	0.280	0.987	Nonconserved	0.003	2.667	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.142	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	1	1:23	0.04	N
chr10	93021	93021	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1311G>C:p.E437D|ENSG00000173876:ENST00000309812:exon4:c.1311G>C:p.E437D,ENSG00000173876:ENST00000447903:exon4:c.1095G>C:p.E365D|TUBB8:uc001ifi.2:exon4:c.1311G>C:p.E437D|CCDS7051.1:CCDS7051.1:exon4:c.1311G>C:p.E437D	10p15.3	0.151	Tolerable	0.267	Benign	0.217	Benign	0.246	Unknown	1	Disease_causing	1.055	Low	-0.71	Tolerable	-0.46	Tolerable	0.311	Tolerable	-0.984	Tolerable	0.133	Tolerable	0.012	Tolerable	0.068	3.274	Tolerable	0.374	Tolerable	0.263	Tolerable	-1.143	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	0.094	Nonconserved	0.280	0.987	Nonconserved	0.003	2.667	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.142	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	1	1:23	0.04	N
chr10	93021	93021	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1311G>A:p.E437E|ENSG00000173876:ENST00000309812:exon4:c.1311G>A:p.E437E,ENSG00000173876:ENST00000447903:exon4:c.1095G>A:p.E365E|TUBB8:uc001ifi.2:exon4:c.1311G>A:p.E437E|CCDS7051.1:CCDS7051.1:exon4:c.1311G>A:p.E437E	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93021	93023	CTC	-	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonframeshift|nonframeshift|nonframeshift|nonframeshift	deletion	TUBB8:NM_177987:exon4:c.1309_1311del:p.437_437del|ENSG00000173876:ENST00000309812:exon4:c.1309_1311del:p.437_437del,ENSG00000173876:ENST00000447903:exon4:c.1093_1095del:p.365_365del|TUBB8:uc001ifi.2:exon4:c.1309_1311del:p.437_437del|CCDS7051.1:CCDS7051.1:exon4:c.1309_1311del:p.437_437del	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	4.809e-06	0	0	0	0	0	1.096e-05	0	0	3.529e-05	0.0001	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93022	93022	-	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	frameshift|frameshift|frameshift|frameshift	insertion	TUBB8:NM_177987:exon4:c.1309dupG:p.E437fs|ENSG00000173876:ENST00000309812:exon4:c.1309dupG:p.E437fs,ENSG00000173876:ENST00000447903:exon4:c.1093dupG:p.E365fs|TUBB8:uc001ifi.2:exon4:c.1309dupG:p.E437fs|CCDS7051.1:CCDS7051.1:exon4:c.1309dupG:p.E437fs	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	9.504e-06	0	0	0	0	0	2.165e-05	0	0	-	-	-	-	-	-	-	-	-	-	-	rs782356132	5.066e-05	0	0	0	0	8.925e-05	0	0	6.372e-05	0	0	0	0	0.0001	0	0	-	-	-	-	-	-	-	-	1.29e-05	2	154602	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	1	Y
chr10	93022	93022	T	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1310A>T:p.E437V|ENSG00000173876:ENST00000309812:exon4:c.1310A>T:p.E437V,ENSG00000173876:ENST00000447903:exon4:c.1094A>T:p.E365V|TUBB8:uc001ifi.2:exon4:c.1310A>T:p.E437V|CCDS7051.1:CCDS7051.1:exon4:c.1310A>T:p.E437V	10p15.3	0.001	Damaging	0.824	Possibly_damaging	0.403	Benign	0.246	Unknown	1	Disease_causing	2.32	Medium	-0.8	Tolerable	-1.39	Tolerable	0.372	Tolerable	-0.573	Tolerable	0.258	Tolerable	0.019	Tolerable	1.341	12.48	Tolerable	0.527	Tolerable	0.764	Damaging	-0.595	Tolerable	0.001	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.655	Conserved	0.310	1.000	Conserved	0.005	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.278	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93022	93022	T	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1310A>G:p.E437G|ENSG00000173876:ENST00000309812:exon4:c.1310A>G:p.E437G,ENSG00000173876:ENST00000447903:exon4:c.1094A>G:p.E365G|TUBB8:uc001ifi.2:exon4:c.1310A>G:p.E437G|CCDS7051.1:CCDS7051.1:exon4:c.1310A>G:p.E437G	10p15.3	0.027	Damaging	0.659	Possibly_damaging	0.403	Benign	0.246	Unknown	1	Disease_causing	1.72	Low	-0.71	Tolerable	-1.14	Tolerable	0.311	Tolerable	-0.738	Tolerable	0.213	Tolerable	0.018	Tolerable	0.786	9.375	Tolerable	0.464	Tolerable	0.738	Damaging	-0.660	Tolerable	0.001	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.655	Conserved	0.310	1.000	Conserved	0.005	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.266	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93022	93022	T	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1310A>C:p.E437A|ENSG00000173876:ENST00000309812:exon4:c.1310A>C:p.E437A,ENSG00000173876:ENST00000447903:exon4:c.1094A>C:p.E365A|TUBB8:uc001ifi.2:exon4:c.1310A>C:p.E437A|CCDS7051.1:CCDS7051.1:exon4:c.1310A>C:p.E437A	10p15.3	0.003	Damaging	0.458	Possibly_damaging	0.292	Benign	0.246	Neutral	1	Disease_causing	2.52	Medium	-0.79	Tolerable	-1.23	Tolerable	0.341	Tolerable	-0.668	Tolerable	0.263	Tolerable	0.012	Tolerable	0.440	6.950	Tolerable	0.454	Tolerable	0.773	Damaging	-0.700	Tolerable	0.001	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.655	Conserved	0.310	1.000	Conserved	0.005	4.622	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.281	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93022	93022	T	TC	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	frameshift|frameshift|frameshift|frameshift	block substitution	TUBB8:NM_177987:exon4:c.1310_1310delinsGA|ENSG00000173876:ENST00000309812:exon4:c.1310_1310delinsGA,ENSG00000173876:ENST00000447903:exon4:c.1094_1094delinsGA|TUBB8:uc001ifi.2:exon4:c.1310_1310delinsGA|CCDS7051.1:CCDS7051.1:exon4:c.1310_1310delinsGA	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	9.504e-06	0	0	0	0	0	2.165e-05	0	0	-	-	-	-	-	-	-	-	-	-	-	rs782356132	5.066e-05	0	0	0	0	8.925e-05	0	0	6.372e-05	0	0	0	0	0.0001	0	0	-	-	-	-	-	-	-	-	1.29e-05	2	154602	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	1	Y
chr10	93023	93023	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	stopgain|stopgain|stopgain|stopgain	SNV	TUBB8:NM_177987:exon4:c.1309G>T:p.E437X|ENSG00000173876:ENST00000309812:exon4:c.1309G>T:p.E437X,ENSG00000173876:ENST00000447903:exon4:c.1093G>T:p.E365X|TUBB8:uc001ifi.2:exon4:c.1309G>T:p.E437X|CCDS7051.1:CCDS7051.1:exon4:c.1309G>T:p.E437X	10p15.3	-	-	-	-	-	-	0.246	Unknown	1	Disease_causing	-	-	-	-	-	-	-	-	-	-	-	-	-	-	8.410	35	Damaging	0.977	Tolerable	0.787	Damaging	-0.170	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.576	Conserved	0.280	1.000	Conserved	0.006	5.991	Nonconserved	-	0	0	0	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	Uncertain significance	rs781856585	0	0	0	0	0	0	0	0	-	-	-	-	-	-	-	-	0	0	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:12	1	Y
chr10	93023	93023	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1309G>C:p.E437Q|ENSG00000173876:ENST00000309812:exon4:c.1309G>C:p.E437Q,ENSG00000173876:ENST00000447903:exon4:c.1093G>C:p.E365Q|TUBB8:uc001ifi.2:exon4:c.1309G>C:p.E437Q|CCDS7051.1:CCDS7051.1:exon4:c.1309G>C:p.E437Q	10p15.3	0.011	Damaging	0.659	Possibly_damaging	0.403	Benign	0.246	Unknown	1	Disease_causing	3.125	Medium	-0.79	Tolerable	-0.72	Tolerable	0.276	Tolerable	-0.730	Tolerable	0.275	Tolerable	0.011	Tolerable	0.386	6.491	Tolerable	0.501	Tolerable	0.795	Damaging	-0.646	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.576	Conserved	0.280	1.000	Conserved	0.006	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.259	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93023	93023	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1309G>A:p.E437K|ENSG00000173876:ENST00000309812:exon4:c.1309G>A:p.E437K,ENSG00000173876:ENST00000447903:exon4:c.1093G>A:p.E365K|TUBB8:uc001ifi.2:exon4:c.1309G>A:p.E437K|CCDS7051.1:CCDS7051.1:exon4:c.1309G>A:p.E437K	10p15.3	0.004	Damaging	0.458	Possibly_damaging	0.292	Benign	0.246	Unknown	1	Disease_causing	3.325	Medium	-0.79	Tolerable	-1.0	Tolerable	0.432	Tolerable	-0.590	Tolerable	0.271	Tolerable	0.018	Tolerable	1.570	13.69	Tolerable	0.609	Tolerable	0.750	Damaging	-0.693	Tolerable	0.007	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	5.576	Conserved	0.280	1.000	Conserved	0.006	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.285	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	5	5:23	0.22	N
chr10	93024	93024	C	A	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1308G>T:p.E436D|ENSG00000173876:ENST00000309812:exon4:c.1308G>T:p.E436D,ENSG00000173876:ENST00000447903:exon4:c.1092G>T:p.E364D|TUBB8:uc001ifi.2:exon4:c.1308G>T:p.E436D|CCDS7051.1:CCDS7051.1:exon4:c.1308G>T:p.E436D	10p15.3	0.124	Tolerable	0.0	Benign	0.0	Benign	0.467	Neutral	1	Disease_causing	0.965	Low	-0.6	Tolerable	-0.21	Tolerable	0.259	Tolerable	-0.992	Tolerable	0.171	Tolerable	0.020	Tolerable	0.127	3.901	Tolerable	0.537	Tolerable	0.032	Tolerable	-1.326	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	-1.370	Nonconserved	0.280	0.092	Nonconserved	0.006	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.174	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	1	1:23	0.04	N
chr10	93024	93024	C	G	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	nonsynonymous|nonsynonymous|nonsynonymous|nonsynonymous	SNV	TUBB8:NM_177987:exon4:c.1308G>C:p.E436D|ENSG00000173876:ENST00000309812:exon4:c.1308G>C:p.E436D,ENSG00000173876:ENST00000447903:exon4:c.1092G>C:p.E364D|TUBB8:uc001ifi.2:exon4:c.1308G>C:p.E436D|CCDS7051.1:CCDS7051.1:exon4:c.1308G>C:p.E436D	10p15.3	0.124	Tolerable	0.0	Benign	0.0	Benign	0.467	Neutral	1	Disease_causing	0.965	Low	-0.6	Tolerable	-0.21	Tolerable	0.259	Tolerable	-0.992	Tolerable	0.171	Tolerable	0.020	Tolerable	-0.126	1.543	Tolerable	0.395	Tolerable	0.033	Tolerable	-1.326	Tolerable	0.000	Tolerable	0.554	Tolerable	0	0.109	Nonconserved	-1.370	Nonconserved	0.280	0.092	Nonconserved	0.006	5.991	Nonconserved	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0.174	Tolerable	Uncertain significance	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	1	1:23	0.04	N
chr10	93024	93024	C	T	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	synonymous|synonymous|synonymous|synonymous	SNV	TUBB8:NM_177987:exon4:c.1308G>A:p.E436E|ENSG00000173876:ENST00000309812:exon4:c.1308G>A:p.E436E,ENSG00000173876:ENST00000447903:exon4:c.1092G>A:p.E364E|TUBB8:uc001ifi.2:exon4:c.1308G>A:p.E436E|CCDS7051.1:CCDS7051.1:exon4:c.1308G>A:p.E436E	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Likely benign	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	0	N
chr10	93025	93025	-	C	RefSeq_Gene|Ensembl_Gene|UCSC_known_gene|CCDS_gene	exonic|exonic|exonic|exonic	TUBB8|ENSG00000173876|TUBB8|CCDS7051.1	frameshift|frameshift|frameshift|frameshift	insertion	TUBB8:NM_177987:exon4:c.1306dupG:p.E436fs|ENSG00000173876:ENST00000309812:exon4:c.1306dupG:p.E436fs,ENSG00000173876:ENST00000447903:exon4:c.1090dupG:p.E364fs|TUBB8:uc001ifi.2:exon4:c.1306dupG:p.E436fs|CCDS7051.1:CCDS7051.1:exon4:c.1306dupG:p.E436fs	10p15.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	0	0	0	0	0	0	0	0	0	3.476e-05	0.0001	0	0	0	0	0	0	-	-	-	rs781921025	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Score=0.974026;chr18:14414	1.085596208(%9.50143)	0.150760231(%67.4925)	-	0	0:0	1	Y
